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Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation

Journal Article:

Abstract

The spatial distribution of cell death among the epithelial cells lining the adult mouse small intestinal mucosa at various times after a range of doses of 10 different drugs as well as after internal or external irradiation (..beta.. particles from tritium, ..gamma..- and X-rays and neutrons) has been recorded. Cell death, expressed as pycnosis or apoptosis, has been recorded for each cell position up the side of the crypts of the small intestine. Adriamycin and the various forms of radiation tend to kill cells preferentially at cell position 4-5 i.e. on cells very early in the lineage, probably stem cells. Isopropyl-methane-sulphonate, nitrogen mustard and possibly Actinomycin-D act on cell position 6-7, while 5-fluorouracil, Myleran, cyclophosphamide, and cycloheximide tend to kill cells at cell position 7-9. Vincristine and hydroxyurea are the 2 agents that exhibit a specificity for cells highest up the crypt, i.e. latest in transit population of the cell lineage by acting on cell positions 10 or 11. The data also suggest that normal healthy cells continue to migrate up the crypt and onto the villus in spite of considerable cell death and reduced cell production.
Authors:
Ijiri, K; Potter, C S [1] 
  1. Christie Hospital and Holt Radium Inst., Manchester (UK). Paterson Labs.
Publication Date:
Feb 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-14-795356; EDB-83-197895
Resource Relation:
Journal Name: Br. J. Cancer; (United Kingdom); Journal Volume: 47:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GASTROINTESTINAL TRACT; BIOLOGICAL RADIATION EFFECTS; ACTINOMYCIN; BETA PARTICLES; CELL KILLING; COMPARATIVE EVALUATIONS; CRYPT CELLS; CYCLOHEXIMIDE; DOXORUBICIN; ENDOXAN; FLUOROURACILS; GAMMA RADIATION; HYDROXY COMPOUNDS; MICE; MYLERAN; NEUTRONS; NITROGEN MUSTARD; ONCOVIN; RESPONSE MODIFYING FACTORS; STEM CELLS; UREA; X RADIATION; ALKALOIDS; ALKYLATING AGENTS; AMIDES; AMINES; ANIMAL CELLS; ANIMALS; ANTI-INFECTIVE AGENTS; ANTIBIOTICS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; ANTINEOPLASTIC DRUGS; AZINES; BARYONS; BIOLOGICAL EFFECTS; CARBONIC ACID DERIVATIVES; CHARGED PARTICLES; DIGESTIVE SYSTEM; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTARY PARTICLES; FERMIONS; FUNGICIDES; HADRONS; HETEROCYCLIC COMPOUNDS; IMMUNOSUPPRESSIVE DRUGS; IONIZING RADIATIONS; MAMMALS; NUCLEONS; ORGANIC CHLORINE COMPOUNDS; ORGANIC COMPOUNDS; ORGANIC FLUORINE COMPOUNDS; ORGANIC HALOGEN COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PESTICIDES; PYRIMIDINES; RADIATION EFFECTS; RADIATIONS; RODENTS; SOMATIC CELLS; URACILS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5722605
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJCAA
Submitting Site:
HEDB
Size:
Pages: 175-185
Announcement Date:
Oct 01, 1983

Journal Article:

Citation Formats

Ijiri, K, and Potter, C S. Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. United Kingdom: N. p., 1983. Web.
Ijiri, K, & Potter, C S. Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation. United Kingdom.
Ijiri, K, and Potter, C S. 1983. "Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation." United Kingdom.
@misc{etde_5722605,
title = {Response of intestinal cells of differing topographical and hierarchical status to ten cytotoxic drugs and five sources of radiation}
author = {Ijiri, K, and Potter, C S}
abstractNote = {The spatial distribution of cell death among the epithelial cells lining the adult mouse small intestinal mucosa at various times after a range of doses of 10 different drugs as well as after internal or external irradiation (..beta.. particles from tritium, ..gamma..- and X-rays and neutrons) has been recorded. Cell death, expressed as pycnosis or apoptosis, has been recorded for each cell position up the side of the crypts of the small intestine. Adriamycin and the various forms of radiation tend to kill cells preferentially at cell position 4-5 i.e. on cells very early in the lineage, probably stem cells. Isopropyl-methane-sulphonate, nitrogen mustard and possibly Actinomycin-D act on cell position 6-7, while 5-fluorouracil, Myleran, cyclophosphamide, and cycloheximide tend to kill cells at cell position 7-9. Vincristine and hydroxyurea are the 2 agents that exhibit a specificity for cells highest up the crypt, i.e. latest in transit population of the cell lineage by acting on cell positions 10 or 11. The data also suggest that normal healthy cells continue to migrate up the crypt and onto the villus in spite of considerable cell death and reduced cell production.}
journal = {Br. J. Cancer; (United Kingdom)}
volume = {47:2}
journal type = {AC}
place = {United Kingdom}
year = {1983}
month = {Feb}
}