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Dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice

Journal Article:

Abstract

The form of the dose-response for induction of malignant diseases in vivo by ionizing radiation is not yet established in spite of its scientific interest and its practical importance. Considerably extended observations have confirmed that the dose-response for acute myeloid leukaemia induced in male CBA/H mice by X-ray exposure is highly curvilinear. The dose-response was well fitted by the expression aD/sup 2/esup(-..gamma..D) (D = dose) in agreement with induction at the cellular level in proportion to D/sup 2/ over the whole dose range 0.25-6.0 Gy. The factor esup(-..gamma..D) accounts for the inescapable concomitant inactivating action of the inducing irradiation. The quantitative aspects of induction of myeloid leukaemia by ionizing radiation are unlike the induction of genetic mutation or cell inactivation and suggest that interaction of two adjoining cells is an essential element in radiation leukaemogenesis.
Authors:
Mole, R H; Papworth, D G; Corp, M J [1] 
  1. Medical Research Council, Harwell (UK). Radiobiological Research Unit
Publication Date:
Feb 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-14-795357; EDB-83-197896
Resource Relation:
Journal Name: Br. J. Cancer; (United Kingdom); Journal Volume: 47:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LEUKEMIA; RADIOINDUCTION; X RADIATION; LEUKEMOGENESIS; DOSE-RESPONSE RELATIONSHIPS; IN VIVO; MICE; ANIMALS; CARCINOGENESIS; DISEASES; ELECTROMAGNETIC RADIATION; HEMIC DISEASES; IONIZING RADIATIONS; MAMMALS; NEOPLASMS; PATHOGENESIS; RADIATIONS; RODENTS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5722596
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJCAA
Submitting Site:
HEDB
Size:
Pages: 285-291
Announcement Date:

Journal Article:

Citation Formats

Mole, R H, Papworth, D G, and Corp, M J. Dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice. United Kingdom: N. p., 1983. Web.
Mole, R H, Papworth, D G, & Corp, M J. Dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice. United Kingdom.
Mole, R H, Papworth, D G, and Corp, M J. 1983. "Dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice." United Kingdom.
@misc{etde_5722596,
title = {Dose-response for X-ray induction of myeloid leukaemia in male CBA/H mice}
author = {Mole, R H, Papworth, D G, and Corp, M J}
abstractNote = {The form of the dose-response for induction of malignant diseases in vivo by ionizing radiation is not yet established in spite of its scientific interest and its practical importance. Considerably extended observations have confirmed that the dose-response for acute myeloid leukaemia induced in male CBA/H mice by X-ray exposure is highly curvilinear. The dose-response was well fitted by the expression aD/sup 2/esup(-..gamma..D) (D = dose) in agreement with induction at the cellular level in proportion to D/sup 2/ over the whole dose range 0.25-6.0 Gy. The factor esup(-..gamma..D) accounts for the inescapable concomitant inactivating action of the inducing irradiation. The quantitative aspects of induction of myeloid leukaemia by ionizing radiation are unlike the induction of genetic mutation or cell inactivation and suggest that interaction of two adjoining cells is an essential element in radiation leukaemogenesis.}
journal = {Br. J. Cancer; (United Kingdom)}
volume = {47:2}
journal type = {AC}
place = {United Kingdom}
year = {1983}
month = {Feb}
}