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Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation

Abstract

Ozone, a major chemical oxidant in the atmosphere, is an environmental air pollutant whose ability to act as a direct carcinogen is unclear. Using in vitro transformation, a technique which permits the study of oncogenesis in the absence of host specific effects, it is reported for the first time that ozone (5 p.p.m. for 5 min) induces neoplastic transformation in vitro in both primary hamster embryo cells and mouse fibroblast cultures (C3H/10-1/2). Exposure of the hamster and mouse cells to ozone also results in enhanced levels of free radical-mediated lipid peroxidation products. The carcinogenic interaction between ozone and ionizing radiation is also reported. Exposure of the cells to 3 or 4 Gy of ..gamma..-rays, 2 h prior to O/sub 3/ treatment, results in markedly enhanced rates of transformation, statistically consistent with a synergistic interaction between the agents. The results demonstrate that O/sub 3/ acts as a direct carcinogen and co-carcinogen on susceptible cells, therefore having important consequences for public health.
Publication Date:
Sep 01, 1986
Product Type:
Journal Article
Reference Number:
GBN-86-004767; EDB-88-021397
Resource Relation:
Journal Name: Carcinogenesis; (United Kingdom); Journal Volume: 7:9
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGENS; OZONE; ONCOGENIC TRANSFORMATIONS; SYNERGISM; CELL CULTURES; EMBRYONIC CELLS; FIBROBLASTS; GAMMA RADIATION; HAMSTERS; IN VITRO; MICE; ANIMAL CELLS; ANIMALS; CELL TRANSFORMATIONS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture
OSTI ID:
5718099
Research Organizations:
Columbia Univ., New York, USA. Radiological Research Lab.; Columbia Univ., New York, US. Cancer Center; Rutgers Medical School, Piscataway, NJ, US
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CRNGD
Submitting Site:
GBN
Size:
Pages: 1611-1613
Announcement Date:

Citation Formats

Borek, C, Zaider, M, Ong, A, Mason, H, and Witz, G. Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation. United Kingdom: N. p., 1986. Web. doi:10.1093/carcin/7.9.1611.
Borek, C, Zaider, M, Ong, A, Mason, H, & Witz, G. Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation. United Kingdom. doi:10.1093/carcin/7.9.1611.
Borek, C, Zaider, M, Ong, A, Mason, H, and Witz, G. 1986. "Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation." United Kingdom. doi:10.1093/carcin/7.9.1611. https://www.osti.gov/servlets/purl/10.1093/carcin/7.9.1611.
@misc{etde_5718099,
title = {Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation}
author = {Borek, C, Zaider, M, Ong, A, Mason, H, and Witz, G}
abstractNote = {Ozone, a major chemical oxidant in the atmosphere, is an environmental air pollutant whose ability to act as a direct carcinogen is unclear. Using in vitro transformation, a technique which permits the study of oncogenesis in the absence of host specific effects, it is reported for the first time that ozone (5 p.p.m. for 5 min) induces neoplastic transformation in vitro in both primary hamster embryo cells and mouse fibroblast cultures (C3H/10-1/2). Exposure of the hamster and mouse cells to ozone also results in enhanced levels of free radical-mediated lipid peroxidation products. The carcinogenic interaction between ozone and ionizing radiation is also reported. Exposure of the cells to 3 or 4 Gy of ..gamma..-rays, 2 h prior to O/sub 3/ treatment, results in markedly enhanced rates of transformation, statistically consistent with a synergistic interaction between the agents. The results demonstrate that O/sub 3/ acts as a direct carcinogen and co-carcinogen on susceptible cells, therefore having important consequences for public health.}
doi = {10.1093/carcin/7.9.1611}
journal = {Carcinogenesis; (United Kingdom)}
volume = {7:9}
journal type = {AC}
place = {United Kingdom}
year = {1986}
month = {Sep}
}