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Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation

Abstract

Ozone, a major chemical oxidant in the atmosphere, is an environmental air pollutant whose ability to act as a direct carcinogen is unclear. Using in vitro transformation, a technique which permits the study of oncogenesis in the absence of host specific effects, it is reported for the first time that ozone (5 p.p.m. for 5 min) induces neoplastic transformation in vitro in both primary hamster embryo cells and mouse fibroblast cultures (C3H/10-1/2). Exposure of the hamster and mouse cells to ozone also results in enhanced levels of free radical-mediated lipid peroxidation products. The carcinogenic interaction between ozone and ionizing radiation is also reported. Exposure of the cells to 3 or 4 Gy of ..gamma..-rays, 2 h prior to O/sub 3/ treatment, results in markedly enhanced rates of transformation, statistically consistent with a synergistic interaction between the agents. The results demonstrate that O/sub 3/ acts as a direct carcinogen and co-carcinogen on susceptible cells, therefore having important consequences for public health.
Publication Date:
Sep 01, 1986
Product Type:
Journal Article
Reference Number:
GBN-86-004767; EDB-88-021397
Resource Relation:
Journal Name: Carcinogenesis; (United Kingdom); Journal Volume: 7:9
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CARCINOGENS; OZONE; ONCOGENIC TRANSFORMATIONS; SYNERGISM; CELL CULTURES; EMBRYONIC CELLS; FIBROBLASTS; GAMMA RADIATION; HAMSTERS; IN VITRO; MICE; ANIMAL CELLS; ANIMALS; CELL TRANSFORMATIONS; CONNECTIVE TISSUE CELLS; ELECTROMAGNETIC RADIATION; IONIZING RADIATIONS; MAMMALS; RADIATIONS; RODENTS; SOMATIC CELLS; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture
OSTI ID:
5718099
Research Organizations:
Columbia Univ., New York, USA. Radiological Research Lab.; Columbia Univ., New York, US. Cancer Center; Rutgers Medical School, Piscataway, NJ, US
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CRNGD
Submitting Site:
GBN
Size:
Pages: 1611-1613
Announcement Date:
Dec 01, 1987

Citation Formats

Borek, C, Zaider, M, Ong, A, Mason, H, and Witz, G. Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation. United Kingdom: N. p., 1986. Web. doi:10.1093/carcin/7.9.1611.
Borek, C, Zaider, M, Ong, A, Mason, H, & Witz, G. Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation. United Kingdom. doi:10.1093/carcin/7.9.1611.
Borek, C, Zaider, M, Ong, A, Mason, H, and Witz, G. 1986. "Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation." United Kingdom. doi:10.1093/carcin/7.9.1611. https://www.osti.gov/servlets/purl/10.1093/carcin/7.9.1611.
@misc{etde_5718099,
title = {Ozone acts alone and synergistically with ionizing radiation to induce in vitro neoplastic transformation}
author = {Borek, C, Zaider, M, Ong, A, Mason, H, and Witz, G}
abstractNote = {Ozone, a major chemical oxidant in the atmosphere, is an environmental air pollutant whose ability to act as a direct carcinogen is unclear. Using in vitro transformation, a technique which permits the study of oncogenesis in the absence of host specific effects, it is reported for the first time that ozone (5 p.p.m. for 5 min) induces neoplastic transformation in vitro in both primary hamster embryo cells and mouse fibroblast cultures (C3H/10-1/2). Exposure of the hamster and mouse cells to ozone also results in enhanced levels of free radical-mediated lipid peroxidation products. The carcinogenic interaction between ozone and ionizing radiation is also reported. Exposure of the cells to 3 or 4 Gy of ..gamma..-rays, 2 h prior to O/sub 3/ treatment, results in markedly enhanced rates of transformation, statistically consistent with a synergistic interaction between the agents. The results demonstrate that O/sub 3/ acts as a direct carcinogen and co-carcinogen on susceptible cells, therefore having important consequences for public health.}
doi = {10.1093/carcin/7.9.1611}
journal = {Carcinogenesis; (United Kingdom)}
volume = {7:9}
journal type = {AC}
place = {United Kingdom}
year = {1986}
month = {Sep}
}