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X irradiation of human epidermis in vitro. 2. Comparison of single 44 kV and 200 kV X irradiation

Journal Article:

Abstract

On the example of the reduction of epidermal adhesion of FITC wheat germ agglutinine (WGA) the direct membrane effect of a single X irradiation (44 kV and 220 kV) was analyzed in vitro. Human normal skin and psoriasis centres were compared. Normal skin showed no alteration of microscopically visible FITC-WGA adhesion on epidermal cells over the whole dose range. Foci of psoriasis responded to doses of /ge/ 5 Gy (44 and 220 kV) with a drastic reduction of epidermal lectin binding to lower and medium cell layers. Maximum efficacy was with 5 Gy (44 kV) or 10 Gy (220 kV). A dose elevation up to 20 Gy did not result in an increase of efficacy. Topographically the radiosensitive FITC-WGA adhesion could chiefly be seen in the dermal ridges. The findings support the impression of an increased radiosensitivity of the lesional psoriatic epidermis compared with normal skin. This is connected with an abnormal differentiation of keratinocytes in psoriasis. (author).
Publication Date:
Jan 01, 1989
Product Type:
Journal Article
Reference Number:
AIX-20-065680; EDB-89-127114
Resource Relation:
Journal Name: Radiobiol., Radiother.; (German Democratic Republic); Journal Volume: 30:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EPIDERMIS; X RADIATION; BIOLOGICAL RADIATION EFFECTS; AGGLUTININS; DOSE-RESPONSE RELATIONSHIPS; IN VITRO; LECTINS; MAN; PATIENTS; PSORIASIS; RADIOSENSITIVITY; ANIMAL TISSUES; ANIMALS; ANTIBODIES; BIOLOGICAL EFFECTS; BODY; DISEASES; ELECTROMAGNETIC RADIATION; EPITHELIUM; IONIZING RADIATIONS; MAMMALS; ORGANS; PRIMATES; RADIATION EFFECTS; RADIATIONS; SKIN; SKIN DISEASES; TISSUES; VERTEBRATES; 560120* - Radiation Effects on Biochemicals, Cells, & Tissue Culture
OSTI ID:
5716572
Research Organizations:
Jena Univ. (German Democratic Republic). Bereich Medizin; Jena Univ. (German Democratic Republic). Radiologische Klinik und Poliklinik
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: CODEN: RDBGA
Submitting Site:
INIS
Size:
Pages: 265-270
Announcement Date:
May 01, 1989

Journal Article:

Citation Formats

Wollina, U, Fueller, J, Burger, B, and Hipler, C. X irradiation of human epidermis in vitro. 2. Comparison of single 44 kV and 200 kV X irradiation. Germany: N. p., 1989. Web.
Wollina, U, Fueller, J, Burger, B, & Hipler, C. X irradiation of human epidermis in vitro. 2. Comparison of single 44 kV and 200 kV X irradiation. Germany.
Wollina, U, Fueller, J, Burger, B, and Hipler, C. 1989. "X irradiation of human epidermis in vitro. 2. Comparison of single 44 kV and 200 kV X irradiation." Germany.
@misc{etde_5716572,
title = {X irradiation of human epidermis in vitro. 2. Comparison of single 44 kV and 200 kV X irradiation}
author = {Wollina, U, Fueller, J, Burger, B, and Hipler, C}
abstractNote = {On the example of the reduction of epidermal adhesion of FITC wheat germ agglutinine (WGA) the direct membrane effect of a single X irradiation (44 kV and 220 kV) was analyzed in vitro. Human normal skin and psoriasis centres were compared. Normal skin showed no alteration of microscopically visible FITC-WGA adhesion on epidermal cells over the whole dose range. Foci of psoriasis responded to doses of /ge/ 5 Gy (44 and 220 kV) with a drastic reduction of epidermal lectin binding to lower and medium cell layers. Maximum efficacy was with 5 Gy (44 kV) or 10 Gy (220 kV). A dose elevation up to 20 Gy did not result in an increase of efficacy. Topographically the radiosensitive FITC-WGA adhesion could chiefly be seen in the dermal ridges. The findings support the impression of an increased radiosensitivity of the lesional psoriatic epidermis compared with normal skin. This is connected with an abnormal differentiation of keratinocytes in psoriasis. (author).}
journal = {Radiobiol., Radiother.; (German Democratic Republic)}
volume = {30:3}
journal type = {AC}
place = {Germany}
year = {1989}
month = {Jan}
}