Abstract
Pigs were gamma irradiated on the thigh such that the dose was 40 to 84 Gy in the muscle (2 cm under the skin). The authors concluded that late effects of acute muscle irradiation were the development of an invasive fibrous tissue which spread out into adjacent normal parenchyma. Cells from the radioinduced fibrosis had greater growth potential than cells from post-surgical scar tissue. Both radioinduced fibrosis in vivo, and fibroblasts extracted from this tissue and grown in vitro, synthetized considerable amounts of fibronectin. Fibronectin is known to play a major role in mediating cell adhesion (Pearlstein et al 1980). These first results indicate that primary cell culture is a suitable approach for studying the nature of radioinduced fibrotic regions.
Citation Formats
Remy, J, Martin, M, Lefaix, J L, and Daburon, F.
Radiation-induced fibrosis in pig muscle: pathological and cellular observations.
United Kingdom: N. p.,
1986.
Web.
Remy, J, Martin, M, Lefaix, J L, & Daburon, F.
Radiation-induced fibrosis in pig muscle: pathological and cellular observations.
United Kingdom.
Remy, J, Martin, M, Lefaix, J L, and Daburon, F.
1986.
"Radiation-induced fibrosis in pig muscle: pathological and cellular observations."
United Kingdom.
@misc{etde_5713898,
title = {Radiation-induced fibrosis in pig muscle: pathological and cellular observations}
author = {Remy, J, Martin, M, Lefaix, J L, and Daburon, F}
abstractNote = {Pigs were gamma irradiated on the thigh such that the dose was 40 to 84 Gy in the muscle (2 cm under the skin). The authors concluded that late effects of acute muscle irradiation were the development of an invasive fibrous tissue which spread out into adjacent normal parenchyma. Cells from the radioinduced fibrosis had greater growth potential than cells from post-surgical scar tissue. Both radioinduced fibrosis in vivo, and fibroblasts extracted from this tissue and grown in vitro, synthetized considerable amounts of fibronectin. Fibronectin is known to play a major role in mediating cell adhesion (Pearlstein et al 1980). These first results indicate that primary cell culture is a suitable approach for studying the nature of radioinduced fibrotic regions.}
journal = []
volume = {53:Suppl. 7}
place = {United Kingdom}
year = {1986}
month = {Jan}
}
title = {Radiation-induced fibrosis in pig muscle: pathological and cellular observations}
author = {Remy, J, Martin, M, Lefaix, J L, and Daburon, F}
abstractNote = {Pigs were gamma irradiated on the thigh such that the dose was 40 to 84 Gy in the muscle (2 cm under the skin). The authors concluded that late effects of acute muscle irradiation were the development of an invasive fibrous tissue which spread out into adjacent normal parenchyma. Cells from the radioinduced fibrosis had greater growth potential than cells from post-surgical scar tissue. Both radioinduced fibrosis in vivo, and fibroblasts extracted from this tissue and grown in vitro, synthetized considerable amounts of fibronectin. Fibronectin is known to play a major role in mediating cell adhesion (Pearlstein et al 1980). These first results indicate that primary cell culture is a suitable approach for studying the nature of radioinduced fibrotic regions.}
journal = []
volume = {53:Suppl. 7}
place = {United Kingdom}
year = {1986}
month = {Jan}
}