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Decrease of glucose-induced insulin secretion of rat pancreatic islets after irradiation in vitro

Journal Article:

Abstract

In vitro irradiation of rat pancreatic islets up to a dose of 2.5 Gy did neither alter glucose- nor isobutylmethyl xanthine (IBMX)-induced insulin secretion. Insulin as well as glucagon content of irradiated islets corresponded to that of the control tissue. So it was in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. There was no indication of an enhanced hormone output in the radiation medium and it is to be suggested that higher radiation doses affect the insulin release of pancreatic islets in vitro. This must be taken into consideration for radioimmunosuppression experiments.
Authors:
Heinzmann, D; Nadrowitz, R; Besch, W; Schmidt, W; Hahn, H J; [1]  Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik)
  1. Zentralinstitut fuer Diabetes, Karlsburg (German Democratic Republic)
Publication Date:
Jan 01, 1983
Product Type:
Journal Article
Reference Number:
AIX-14-764179; EDB-83-193988
Resource Relation:
Journal Name: Endokrinologie; (German Democratic Republic); Journal Volume: 81:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INSULIN; SECRETION; PANCREAS; BIOLOGICAL RADIATION EFFECTS; CELL CULTURES; COBALT 60; DOSE-RESPONSE RELATIONSHIPS; GAMMA RADIATION; GLUCAGON; GLUCOSE; IMMUNOSUPPRESSION; RATS; XANTHINES; ALDEHYDES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; CARBOHYDRATES; COBALT ISOTOPES; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; ENDOCRINE GLANDS; GLANDS; HETEROCYCLIC COMPOUNDS; HEXOSES; HORMONES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; MONOSACCHARIDES; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; ORGANS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; PURINES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RODENTS; SACCHARIDES; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560121* - Radiation Effects on Cells- External Source- (-1987)
OSTI ID:
5713789
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ENDKA
Submitting Site:
HEDB
Size:
Pages: 94-97
Announcement Date:

Journal Article:

Citation Formats

Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, Hahn, H J, and Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik). Decrease of glucose-induced insulin secretion of rat pancreatic islets after irradiation in vitro. Germany: N. p., 1983. Web.
Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, Hahn, H J, & Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik). Decrease of glucose-induced insulin secretion of rat pancreatic islets after irradiation in vitro. Germany.
Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, Hahn, H J, and Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik). 1983. "Decrease of glucose-induced insulin secretion of rat pancreatic islets after irradiation in vitro." Germany.
@misc{etde_5713789,
title = {Decrease of glucose-induced insulin secretion of rat pancreatic islets after irradiation in vitro}
author = {Heinzmann, D, Nadrowitz, R, Besch, W, Schmidt, W, Hahn, H J, and Ernst-Moritz-Arndt-Universitaet, Greifswald (German Democratic Republic). Radiologische Klinik)}
abstractNote = {In vitro irradiation of rat pancreatic islets up to a dose of 2.5 Gy did neither alter glucose- nor isobutylmethyl xanthine (IBMX)-induced insulin secretion. Insulin as well as glucagon content of irradiated islets corresponded to that of the control tissue. So it was in islets irradiated with 25 Gy which were characterized by a decreased insulin secretion in the presence of glucose and IBMX, respectively. There was no indication of an enhanced hormone output in the radiation medium and it is to be suggested that higher radiation doses affect the insulin release of pancreatic islets in vitro. This must be taken into consideration for radioimmunosuppression experiments.}
journal = {Endokrinologie; (German Democratic Republic)}
volume = {81:1}
journal type = {AC}
place = {Germany}
year = {1983}
month = {Jan}
}