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Serum immunoglobulin levels in the ABCC-JNIH adult health study: Hiroshima and Nagasaki

Abstract

Immunoglobulin levels (IgG, IgA, and IgM) were determined on 2043 individuals in the ABCC-JNIH Adult Health Study population, and levels were compared to disease states and the dose of radiation ATB. Mean levels for both cities and sexes combined were IgG = 1577 mg%, IgA = 312 mg%, and IgM = 127 mg%. Differences between these mean levels and those reported in other studies are thought secondary to racial and environmental factors, and technical differences with the methods used for quantitation. Females had higher IgM levels that tended to go down with advancing age. Of the diseases evaluated, rheumatoid arthritis, cirrhosis, and pulmonary tuberculosis affected immunoglobulin levels the greatest. There was no apparent relationship between radiation dose from the atomic bomb and immunoglobulin levels determined more than 25 years after exposure. (6 tables)
Publication Date:
May 31, 1973
Product Type:
Technical Report
Report Number:
ABCC-TR-14-73
Reference Number:
EDB-80-006929
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; IMMUNOGLOBULINS; BLOOD SERUM; BIOLOGICAL RADIATION EFFECTS; DISEASES; HIROSHIMA; NAGASAKI; ASIA; BIOLOGICAL EFFECTS; GLOBULINS; JAPAN; ORGANIC COMPOUNDS; PROTEINS; RADIATION EFFECTS; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5702540
Research Organizations:
Atomic Bomb Casualty Commission, Hiroshima (Japan); Atomic Bomb Casualty Commission, Nagasaki (Japan)
Country of Origin:
Japan
Language:
English and Japanese
Contract Number:
EX-76-C-28-3161
Availability:
Dep. NTIS, PC A02/MF A01.
Submitting Site:
NEDO
Size:
Pages: 25
Announcement Date:
May 13, 2001

Citation Formats

King, R A, Milton, R C, and Hamilton, H B. Serum immunoglobulin levels in the ABCC-JNIH adult health study: Hiroshima and Nagasaki. Japan: N. p., 1973. Web.
King, R A, Milton, R C, & Hamilton, H B. Serum immunoglobulin levels in the ABCC-JNIH adult health study: Hiroshima and Nagasaki. Japan.
King, R A, Milton, R C, and Hamilton, H B. 1973. "Serum immunoglobulin levels in the ABCC-JNIH adult health study: Hiroshima and Nagasaki." Japan.
@misc{etde_5702540,
title = {Serum immunoglobulin levels in the ABCC-JNIH adult health study: Hiroshima and Nagasaki}
author = {King, R A, Milton, R C, and Hamilton, H B}
abstractNote = {Immunoglobulin levels (IgG, IgA, and IgM) were determined on 2043 individuals in the ABCC-JNIH Adult Health Study population, and levels were compared to disease states and the dose of radiation ATB. Mean levels for both cities and sexes combined were IgG = 1577 mg%, IgA = 312 mg%, and IgM = 127 mg%. Differences between these mean levels and those reported in other studies are thought secondary to racial and environmental factors, and technical differences with the methods used for quantitation. Females had higher IgM levels that tended to go down with advancing age. Of the diseases evaluated, rheumatoid arthritis, cirrhosis, and pulmonary tuberculosis affected immunoglobulin levels the greatest. There was no apparent relationship between radiation dose from the atomic bomb and immunoglobulin levels determined more than 25 years after exposure. (6 tables)}
place = {Japan}
year = {1973}
month = {May}
}