Abstract
A rat monoclonal antibody, YPC2/38.8, was selected from a panel of antibodies derived by immunising rats with fresh human colorectal carcinoma. It was found to bind to a 30,000 dalton protein present on the cell surface of normal colon and liver. This protein was increased 10-fold on primary hepatocellular carcinoma (PHC) cells. After labelling with /sup 131/I, YPC2/38.8 was shown to localise human PHCs grown as xenografts in immunosuppressed mice. The authors conclude that YPC2/38.8 may have potential for diagnostic localisation and possibly thence for the selective targeting of drugs or toxins in patients with PHC arising in a liver unaffected by significant parenchymal disease. 16 refs.; 4 figs.; 1 table.
Citation Formats
Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K.
Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody.
Netherlands: N. p.,
1986.
Web.
Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, & Sikora, K.
Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody.
Netherlands.
Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K.
1986.
"Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody."
Netherlands.
@misc{etde_5679118,
title = {Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody}
author = {Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K}
abstractNote = {A rat monoclonal antibody, YPC2/38.8, was selected from a panel of antibodies derived by immunising rats with fresh human colorectal carcinoma. It was found to bind to a 30,000 dalton protein present on the cell surface of normal colon and liver. This protein was increased 10-fold on primary hepatocellular carcinoma (PHC) cells. After labelling with /sup 131/I, YPC2/38.8 was shown to localise human PHCs grown as xenografts in immunosuppressed mice. The authors conclude that YPC2/38.8 may have potential for diagnostic localisation and possibly thence for the selective targeting of drugs or toxins in patients with PHC arising in a liver unaffected by significant parenchymal disease. 16 refs.; 4 figs.; 1 table.}
journal = {J. Hepatol.; (Netherlands)}
volume = {2:1}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {Jan}
}
title = {Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody}
author = {Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K}
abstractNote = {A rat monoclonal antibody, YPC2/38.8, was selected from a panel of antibodies derived by immunising rats with fresh human colorectal carcinoma. It was found to bind to a 30,000 dalton protein present on the cell surface of normal colon and liver. This protein was increased 10-fold on primary hepatocellular carcinoma (PHC) cells. After labelling with /sup 131/I, YPC2/38.8 was shown to localise human PHCs grown as xenografts in immunosuppressed mice. The authors conclude that YPC2/38.8 may have potential for diagnostic localisation and possibly thence for the selective targeting of drugs or toxins in patients with PHC arising in a liver unaffected by significant parenchymal disease. 16 refs.; 4 figs.; 1 table.}
journal = {J. Hepatol.; (Netherlands)}
volume = {2:1}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {Jan}
}