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Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody

Journal Article:

Abstract

A rat monoclonal antibody, YPC2/38.8, was selected from a panel of antibodies derived by immunising rats with fresh human colorectal carcinoma. It was found to bind to a 30,000 dalton protein present on the cell surface of normal colon and liver. This protein was increased 10-fold on primary hepatocellular carcinoma (PHC) cells. After labelling with /sup 131/I, YPC2/38.8 was shown to localise human PHCs grown as xenografts in immunosuppressed mice. The authors conclude that YPC2/38.8 may have potential for diagnostic localisation and possibly thence for the selective targeting of drugs or toxins in patients with PHC arising in a liver unaffected by significant parenchymal disease. 16 refs.; 4 figs.; 1 table.
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-17-039895; EDB-86-121871
Resource Relation:
Journal Name: J. Hepatol.; (Netherlands); Journal Volume: 2:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; HEPATOMAS; BIOLOGICAL LOCALIZATION; RADIOIMMUNOASSAY; LIVER; CARCINOMAS; GRAFTS; IODINE 131; LABELLING; MAN; MONOCLONAL ANTIBODIES; PROTEINS; RATS; ANIMALS; ANTIBODIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; GLANDS; IMMUNOASSAY; IMMUNOLOGY; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MAMMALS; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PRIMATES; RADIOASSAY; RADIOIMMUNOLOGY; RADIOISOTOPES; RODENTS; TRACER TECHNIQUES; TRANSPLANTS; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5679118
Research Organizations:
Addenbrooke's Hospital, Cambridge, UK
Country of Origin:
Netherlands
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JOHEE
Submitting Site:
INIS
Size:
Pages: 25-31
Announcement Date:
Jun 01, 1986

Journal Article:

Citation Formats

Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K. Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody. Netherlands: N. p., 1986. Web.
Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, & Sikora, K. Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody. Netherlands.
Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K. 1986. "Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody." Netherlands.
@misc{etde_5679118,
title = {Primary hepatocellular carcinoma localised by a radiolabelled monoclonal antibody}
author = {Markham, N, Ritson, A, James, O, Curtin, N, Bassendine, M, and Sikora, K}
abstractNote = {A rat monoclonal antibody, YPC2/38.8, was selected from a panel of antibodies derived by immunising rats with fresh human colorectal carcinoma. It was found to bind to a 30,000 dalton protein present on the cell surface of normal colon and liver. This protein was increased 10-fold on primary hepatocellular carcinoma (PHC) cells. After labelling with /sup 131/I, YPC2/38.8 was shown to localise human PHCs grown as xenografts in immunosuppressed mice. The authors conclude that YPC2/38.8 may have potential for diagnostic localisation and possibly thence for the selective targeting of drugs or toxins in patients with PHC arising in a liver unaffected by significant parenchymal disease. 16 refs.; 4 figs.; 1 table.}
journal = {J. Hepatol.; (Netherlands)}
volume = {2:1}
journal type = {AC}
place = {Netherlands}
year = {1986}
month = {Jan}
}