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Effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro

Journal Article:

Abstract

The potentiating effect of caffeine on X-ray-induced chromosomal aberrations in human blood lymphocytes has been investigated, with special reference to cell cycle stages (G0 and G2). Both quantitative and qualitative differences in the yield of chromosomal aberrations were detected in caffeine-posttreated cells, depending on the cell stage irradiated. The studies on caffeine potentiating effects on X-irradiated G0 lymphocytes from normal adults, newborns, Down syndrome patients, and an ataxia telangiectasia patient pointed to interindividual variations in the response to caffeine potentiation among normal probands and a very profound effect in ataxia cells.
Publication Date:
Jan 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-12-591518; EDB-82-060869
Resource Relation:
Journal Name: Humangenetik; (Germany, Federal Republic of); Journal Volume: 54:2
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CAFFEINE; RESPONSE MODIFYING FACTORS; LYMPHOCYTES; RADIOSENSITIVITY; ADULTS; BLOOD; CELL CYCLE; CHROMOSOMAL ABERRATIONS; IN VITRO; INFANTS; NERVOUS SYSTEM DISEASES; PATIENTS; X RADIATION; AGE GROUPS; ANALEPTICS; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD CELLS; BODY FLUIDS; CENTRAL NERVOUS SYSTEM AGENTS; CHILDREN; CONNECTIVE TISSUE CELLS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; HETEROCYCLIC COMPOUNDS; IONIZING RADIATIONS; LEUKOCYTES; MATERIALS; MUTATIONS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC OXYGEN COMPOUNDS; PURINES; RADIATIONS; SOMATIC CELLS; XANTHINES; 560306* - Chemicals Metabolism & Toxicology- Man- (-1987); 560151 - Radiation Effects on Animals- Man
OSTI ID:
5673507
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: HUMAA
Submitting Site:
INIS
Size:
Pages: 183-189
Announcement Date:

Journal Article:

Citation Formats

Natarajan, A T, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)), Obe, G, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands), Freie Univ. Berlin (Germany, F.R.). Inst. fuer Genetik), Dulout, F N, and Instituto Multidisciplinario de Biologia Celular, La Plata (Argentinia)). Effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro. Germany: N. p., 1980. Web.
Natarajan, A T, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)), Obe, G, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands), Freie Univ. Berlin (Germany, F.R.). Inst. fuer Genetik), Dulout, F N, & Instituto Multidisciplinario de Biologia Celular, La Plata (Argentinia)). Effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro. Germany.
Natarajan, A T, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)), Obe, G, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands), Freie Univ. Berlin (Germany, F.R.). Inst. fuer Genetik), Dulout, F N, and Instituto Multidisciplinario de Biologia Celular, La Plata (Argentinia)). 1980. "Effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro." Germany.
@misc{etde_5673507,
title = {Effect of caffeine posttreatment on X-ray-induced chromosomal aberrations in human blood lymphocytes in vitro}
author = {Natarajan, A T, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands)), Obe, G, Cohen (J.A.) Inst. voor Radiopathologie en Stralenbescherming, Leiden (Netherlands), Freie Univ. Berlin (Germany, F.R.). Inst. fuer Genetik), Dulout, F N, and Instituto Multidisciplinario de Biologia Celular, La Plata (Argentinia))}
abstractNote = {The potentiating effect of caffeine on X-ray-induced chromosomal aberrations in human blood lymphocytes has been investigated, with special reference to cell cycle stages (G0 and G2). Both quantitative and qualitative differences in the yield of chromosomal aberrations were detected in caffeine-posttreated cells, depending on the cell stage irradiated. The studies on caffeine potentiating effects on X-irradiated G0 lymphocytes from normal adults, newborns, Down syndrome patients, and an ataxia telangiectasia patient pointed to interindividual variations in the response to caffeine potentiation among normal probands and a very profound effect in ataxia cells.}
journal = {Humangenetik; (Germany, Federal Republic of)}
volume = {54:2}
journal type = {AC}
place = {Germany}
year = {1980}
month = {Jan}
}