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Mutagenicity of vinyl chloride after metabolic activation

Journal Article:

Abstract

Vinyl chloride has recently been shown to cause a malignant liver tumor disease in man after occupational exposure in PVC plants. This actualizes the problem of whether such hazards could be avoided or at least diminished in the future by a screening for mutagenicity of chemicals used in industries. The basis for such a screening procedure is the close correlation between carcinogenic and mutagenic effects of chemicals. Experiments with Salmonella bacteria showed that the carcinogenic hazard of vinyl chloride could have been traced by means of mutagenicity tests. The data indicate that vinyl chloride is not mutagenic per se but becomes mutagenic after a metabolic activation in the liver. 24 references, 1 figure, 4 tables.
Publication Date:
Jan 01, 1974
Product Type:
Journal Article
Reference Number:
EDB-85-117275
Resource Relation:
Journal Name: Ambio; (Norway); Journal Volume: 3:5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MUTAGENS; METABOLIC ACTIVATION; ORGANIC COMPOUNDS; MUTAGEN SCREENING; MUTAGENESIS; BIOLOGICAL PATHWAYS; HEALTH HAZARDS; LIVER; METABOLISM; OCCUPATIONAL EXPOSURE; SALMONELLA; BACTERIA; BODY; DIGESTIVE SYSTEM; GLANDS; HAZARDS; MICROORGANISMS; ORGANS; SCREENING; 560302* - Chemicals Metabolism & Toxicology- Microorganisms- (-1987); 560306 - Chemicals Metabolism & Toxicology- Man- (-1987)
OSTI ID:
5673415
Research Organizations:
Univ. of Stockholm, Sweden
Country of Origin:
Norway
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: AMBOC
Submitting Site:
HEDB
Size:
Pages: 194-197
Announcement Date:
Jul 01, 1985

Journal Article:

Citation Formats

Rannug, U, Johansson, A, Ramel, C, and Wachtmeister, C A. Mutagenicity of vinyl chloride after metabolic activation. Norway: N. p., 1974. Web.
Rannug, U, Johansson, A, Ramel, C, & Wachtmeister, C A. Mutagenicity of vinyl chloride after metabolic activation. Norway.
Rannug, U, Johansson, A, Ramel, C, and Wachtmeister, C A. 1974. "Mutagenicity of vinyl chloride after metabolic activation." Norway.
@misc{etde_5673415,
title = {Mutagenicity of vinyl chloride after metabolic activation}
author = {Rannug, U, Johansson, A, Ramel, C, and Wachtmeister, C A}
abstractNote = {Vinyl chloride has recently been shown to cause a malignant liver tumor disease in man after occupational exposure in PVC plants. This actualizes the problem of whether such hazards could be avoided or at least diminished in the future by a screening for mutagenicity of chemicals used in industries. The basis for such a screening procedure is the close correlation between carcinogenic and mutagenic effects of chemicals. Experiments with Salmonella bacteria showed that the carcinogenic hazard of vinyl chloride could have been traced by means of mutagenicity tests. The data indicate that vinyl chloride is not mutagenic per se but becomes mutagenic after a metabolic activation in the liver. 24 references, 1 figure, 4 tables.}
journal = {Ambio; (Norway)}
volume = {3:5}
journal type = {AC}
place = {Norway}
year = {1974}
month = {Jan}
}