Abstract
We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).
Odano, Ikuo;
Takahashi, Naoya;
Ohtaki, Hiroh;
Noguchi, Eikichi;
Hatano, Masayoshi;
Yamasaki, Yoshihiro;
Nishihara, Mamiko;
[1]
Ohkubo, Masaki;
Yokoi, Takashi
- Niigata Univ. (Japan). School of Medicine
Citation Formats
Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi.
A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT.
Japan: N. p.,
1993.
Web.
Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, & Yokoi, Takashi.
A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT.
Japan.
Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi.
1993.
"A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT."
Japan.
@misc{etde_5672908,
title = {A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT}
author = {Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi}
abstractNote = {We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).}
journal = []
volume = {30:10}
journal type = {AC}
place = {Japan}
year = {1993}
month = {Oct}
}
title = {A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT}
author = {Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi}
abstractNote = {We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).}
journal = []
volume = {30:10}
journal type = {AC}
place = {Japan}
year = {1993}
month = {Oct}
}