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A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT

Journal Article:

Abstract

We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).
Publication Date:
Oct 01, 1993
Product Type:
Journal Article
Reference Number:
JPN-93-012221; EDB-94-032615
Resource Relation:
Journal Name: Kaku Igaku (Japanese Journal of Nuclear Medicine); (Japan); Journal Volume: 30:10
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; BENZEDRINE; BIOLOGICAL FUNCTIONS; BLOOD FLOW; COMPARTMENTS; DOPAMINE; MENTAL DISORDERS; TIME DEPENDENCE; VOLUME; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; BRAIN; CARDIOTONICS; CARDIOVASCULAR AGENTS; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PHENOLS; POLYPHENOLS; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5672908
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0022-7854; CODEN: KAIGBZ
Submitting Site:
JPN
Size:
Pages: 1211-1219
Announcement Date:
Mar 01, 1994

Journal Article:

Citation Formats

Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi. A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT. Japan: N. p., 1993. Web.
Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, & Yokoi, Takashi. A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT. Japan.
Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi. 1993. "A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT." Japan.
@misc{etde_5672908,
title = {A new graphic method for evaluation of distribution volume on N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) SPECT}
author = {Odano, Ikuo, Takahashi, Naoya, Ohtaki, Hiroh, Noguchi, Eikichi, Hatano, Masayoshi, Yamasaki, Yoshihiro, Nishihara, Mamiko, Ohkubo, Masaki, and Yokoi, Takashi}
abstractNote = {We developed a new graphic method using N-isopropyl-p-[[sup 123]I]iodoamphetamine (IMP) and SPECT of the brain, the graph on which all three parameters, cerebral blood flow, distribution volume (V[sub d]) and delayed count to early count ratio (Delayed/Early ratio), were able to be evaluated simultaneously. The kinetics of [sup 123]I-IMP in the brain was analyzed by a 2-compartment model, and a standard input function was prepared by averaging the time activity curves of [sup 123]I-IMP in arterial blood on 6 patients with small cerebral infarction etc. including 2 normal controls. Being applied this method to the differential diagnosis between Parkinson's disease and progressive supranuclear palsy, we were able to differentiate both with a glance, because the distribution volume of the frontal lobe significantly decreased in Parkinson's disease (Mean[+-]SD; 26[+-]6 ml/g). This method was clinically useful. We think that the distribution volume of [sup 123]I-IMP may reflect its retention mechanism in the brain, and the values are related to amine, especially to dopamine receptors and its metabolism. (author).}
journal = {Kaku Igaku (Japanese Journal of Nuclear Medicine); (Japan)}
volume = {30:10}
journal type = {AC}
place = {Japan}
year = {1993}
month = {Oct}
}