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Production of high specific activity /sup 123/I for protein iodination for medical use

Abstract

Iodine-123 is produced via xenon-133 by irradiation of a sodium iodide target with 108 MeV deuterons from the synchrocyclotron of IPN. The on-line production method is described. The specific activity of the iodine is determined by neutron activation analysis and by a radioimmunological method. The conditions labelling different proteins (insulin, angiotensin) are given and also the purification method to obtain a product ready for injection to patients.
Authors:
Legoux, Y; Cieur, M; [1]  Goutheraud, R; Drouet, J; [2]  Crouzel, C; Syrota, A [3] 
  1. Paris-11 Univ., 91 - Orsay (France). Inst. de Physique Nucleaire
  2. Centre National de Transfusion Sanguine, 75 - Paris (France)
  3. CEA, 91 - Orsay (France). Service Hospitalier Frederic Joliot
Publication Date:
Jan 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-16-033653; EDB-85-096021
Resource Relation:
Journal Name: Int. J. Appl. Radiat. Isot.; (United Kingdom); Journal Volume: 36:1
Subject:
38 RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; ANGIOTENSIN; LABELLING; INSULIN; IODINE 123; ISOTOPE PRODUCTION; RADIOCHEMISTRY; LABELLED COMPOUNDS; CHEMICAL PREPARATION; ACTIVATION ANALYSIS; DEUTERON BEAMS; IRRADIATION; MEV RANGE 100-1000; NEUTRON REACTIONS; PH VALUE; RADIOACTIVITY; RADIOIMMUNOASSAY; SODIUM IODIDES; SYNCHROTRONS; XENON 133; ACCELERATORS; ALKALI METAL COMPOUNDS; BARYON REACTIONS; BEAMS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARDIOVASCULAR AGENTS; CHEMICAL ANALYSIS; CHEMISTRY; CYCLIC ACCELERATORS; DAYS LIVING RADIOISOTOPES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; ENERGY RANGE; EVEN-ODD NUCLEI; GLOBULINS; HADRON REACTIONS; HALIDES; HALOGEN COMPOUNDS; HORMONES; HOURS LIVING RADIOISOTOPES; INORGANIC PHOSPHORS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IODIDES; IODINE COMPOUNDS; IODINE ISOTOPES; ION BEAMS; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; MEV RANGE; NUCLEAR REACTIONS; NUCLEI; NUCLEON REACTIONS; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PHOSPHORS; PROTEINS; RADIOASSAY; RADIOISOTOPES; SODIUM COMPOUNDS; SYNTHESIS; TRACER TECHNIQUES; VASOCONSTRICTORS; XENON ISOTOPES; 400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production; 400702 - Radiochemistry & Nuclear Chemistry- Properties of Radioactive Materials; 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5670404
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: IJARA
Submitting Site:
HEDB
Size:
Pages: 63-67
Announcement Date:
May 01, 1985

Citation Formats

Legoux, Y, Cieur, M, Goutheraud, R, Drouet, J, Crouzel, C, and Syrota, A. Production of high specific activity /sup 123/I for protein iodination for medical use. United Kingdom: N. p., 1985. Web. doi:10.1016/0020-708X(85)90056-0.
Legoux, Y, Cieur, M, Goutheraud, R, Drouet, J, Crouzel, C, & Syrota, A. Production of high specific activity /sup 123/I for protein iodination for medical use. United Kingdom. doi:10.1016/0020-708X(85)90056-0.
Legoux, Y, Cieur, M, Goutheraud, R, Drouet, J, Crouzel, C, and Syrota, A. 1985. "Production of high specific activity /sup 123/I for protein iodination for medical use." United Kingdom. doi:10.1016/0020-708X(85)90056-0. https://www.osti.gov/servlets/purl/10.1016/0020-708X(85)90056-0.
@misc{etde_5670404,
title = {Production of high specific activity /sup 123/I for protein iodination for medical use}
author = {Legoux, Y, Cieur, M, Goutheraud, R, Drouet, J, Crouzel, C, and Syrota, A}
abstractNote = {Iodine-123 is produced via xenon-133 by irradiation of a sodium iodide target with 108 MeV deuterons from the synchrocyclotron of IPN. The on-line production method is described. The specific activity of the iodine is determined by neutron activation analysis and by a radioimmunological method. The conditions labelling different proteins (insulin, angiotensin) are given and also the purification method to obtain a product ready for injection to patients.}
doi = {10.1016/0020-708X(85)90056-0}
journal = {Int. J. Appl. Radiat. Isot.; (United Kingdom)}
volume = {36:1}
journal type = {AC}
place = {United Kingdom}
year = {1985}
month = {Jan}
}