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Study of human lung clearance following the administration of radioactive aerosols

Abstract

Within clinical respiratory functional explorations, a pulmonary clearance study was performed on two groups of patients: 20 normal individuals for the former, 18 for the latter, most of them suffering from various diseases (sarcoidosis, tuberculosis, chronic bronchitis and pneumoconiosis). Each group included smokers and non-smokers. /sup 198/Au aerosols were administered to the former group, and /sup 51/Cr-labelled polystyrene spherical particles to the latter. Low-level whole-body ..gamma..-spectrometry was carried out for several weeks or several months. The retention curves are exponential, and the calculated half-lives were compared to several data: age, sex, profession, cigarette smoking rate, spirometric explorations, etiology. The normal biological half-life is about 68 days; it is significatively increased by smoking, it is also increased in the pathological conditions considered, except sarcoidosis.
Authors:
Jammet, H; [1]  Drutel, P; [2]  Parrot, R; [3]  Roy, M [4] 
  1. Institut du Radium, 75 - Paris (France). Lab. Curie
  2. Hopital Beaujon, 92 - Clichy (France)
  3. Centre Medico-Chirurgical de Bligny, 91 - Briis-sous-Forges (France)
  4. CEA Centre d'Etudes Nucleaires de Fontenay-aux-Roses, 92 (France). Dept. de Protection
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-11-496790; EDB-80-037531
Resource Relation:
Journal Name: Radioprotection; (France); Journal Volume: 13:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; CHROMIUM 51; LUNG CLEARANCE; RADIOACTIVE AEROSOLS; BIOLOGICAL HALF-LIFE; DYNAMIC FUNCTION STUDIES; GAMMA SPECTROSCOPY; GOLD 198; MAN; RADIONUCLIDE KINETICS; RETENTION; TOBACCO SMOKES; AEROSOLS; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CHROMIUM ISOTOPES; CLEARANCE; COLLOIDS; DAYS LIVING RADIOISOTOPES; DISPERSIONS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; EXCRETION; GOLD ISOTOPES; HEAVY NUCLEI; INTERMEDIATE MASS NUCLEI; ISOTOPES; MAMMALS; NUCLEI; ODD-ODD NUCLEI; PRIMATES; RADIOISOTOPES; RESIDUES; SMOKES; SOLS; SPECTROSCOPY; VERTEBRATES; 560171* - Radiation Effects- Nuclide Kinetics & Toxicology- Man- (-1987); 551001 - Physiological Systems- Tracer Techniques
OSTI ID:
5655759
Country of Origin:
France
Language:
French
Other Identifying Numbers:
Journal ID: CODEN: RAPRB
Submitting Site:
INIS
Size:
Pages: 143-166
Announcement Date:
Mar 01, 1980

Citation Formats

Jammet, H, Drutel, P, Parrot, R, and Roy, M. Study of human lung clearance following the administration of radioactive aerosols. France: N. p., 1978. Web.
Jammet, H, Drutel, P, Parrot, R, & Roy, M. Study of human lung clearance following the administration of radioactive aerosols. France.
Jammet, H, Drutel, P, Parrot, R, and Roy, M. 1978. "Study of human lung clearance following the administration of radioactive aerosols." France.
@misc{etde_5655759,
title = {Study of human lung clearance following the administration of radioactive aerosols}
author = {Jammet, H, Drutel, P, Parrot, R, and Roy, M}
abstractNote = {Within clinical respiratory functional explorations, a pulmonary clearance study was performed on two groups of patients: 20 normal individuals for the former, 18 for the latter, most of them suffering from various diseases (sarcoidosis, tuberculosis, chronic bronchitis and pneumoconiosis). Each group included smokers and non-smokers. /sup 198/Au aerosols were administered to the former group, and /sup 51/Cr-labelled polystyrene spherical particles to the latter. Low-level whole-body ..gamma..-spectrometry was carried out for several weeks or several months. The retention curves are exponential, and the calculated half-lives were compared to several data: age, sex, profession, cigarette smoking rate, spirometric explorations, etiology. The normal biological half-life is about 68 days; it is significatively increased by smoking, it is also increased in the pathological conditions considered, except sarcoidosis.}
journal = []
volume = {13:3}
journal type = {AC}
place = {France}
year = {1978}
month = {Jan}
}