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Protective properties of plasma of burnt and irradiated rats against lethal effect of endotoxins in vivo

Journal Article:

Abstract

The purpose of this work was to estimate protective properties of plasma in disease with increased endotoxemia. Burns and acute radiation sickness were used as models of suppression of physiological mechanisms of detoxication. Experiments were performed on male Wistar rats and mice, which received 3rd degree burns over 15% of the body surface, whole body gamma irradiation at 7.5 Gr or both. At 3 hours, 3, 7 and 12 days after the exposure the animals were decapitated and blood collected. The irradiated mice received 0.2 ml endotoxin intraperitoneally, 1.0 ml freshly prepared rat plasma, then the lethality of the mice in 24 hours was observed. It was found that the plasma of intact rats was capable of decreasing the lethal effects of S. typhimurium and E. coli endotoxins in vivo in mice. Deep skin burns, acute radiation sickness and the combined effects of radiation and thermal injury did not change this phenomenon. The plasma of the experimental rats retained the protective properties at various periods of time after the thermal, radiation and combined exposures. The functioning of the humoral detoxication mechanism is radioresistant, indirectly indicating the nonimmunoglobulin nature of endotoxin inactivators. 19 references.
Publication Date:
Oct 01, 1984
Product Type:
Journal Article
Reference Number:
EDB-85-107080
Resource Relation:
Journal Name: Zh. Mikrobiol., Epidemiol. Immunobiol.; (USSR); Journal Volume: 10
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; BLOOD PLASMA; RADIOSENSITIVITY EFFECTS; ENDOTOXINS; DETOXIFICATION; SKIN; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL MODELS; GAMMA RADIATION; IMMUNOGLOBULINS; IN VIVO; MICE; RADIATION BURNS; RATS; RESPONSE MODIFYING FACTORS; WHOLE-BODY IRRADIATION; ANIMALS; ANTIGENS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BLOOD; BODY; BODY FLUIDS; BURNS; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GLOBULINS; INJURIES; IONIZING RADIATIONS; IRRADIATION; LOCAL RADIATION EFFECTS; MAMMALS; MATERIALS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIATION EFFECTS; RADIATION INJURIES; RADIATIONS; RODENTS; TOXIC MATERIALS; TOXINS; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5652107
Research Organizations:
Scientific Research Institute of Medical Radiology, Obninsk, USSR
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: ZMEIA
Submitting Site:
HEDB
Size:
Pages: 96-99
Announcement Date:
Jun 01, 1985

Journal Article:

Citation Formats

Budagov, R S, and Chureyeva, L N. Protective properties of plasma of burnt and irradiated rats against lethal effect of endotoxins in vivo. USSR: N. p., 1984. Web.
Budagov, R S, & Chureyeva, L N. Protective properties of plasma of burnt and irradiated rats against lethal effect of endotoxins in vivo. USSR.
Budagov, R S, and Chureyeva, L N. 1984. "Protective properties of plasma of burnt and irradiated rats against lethal effect of endotoxins in vivo." USSR.
@misc{etde_5652107,
title = {Protective properties of plasma of burnt and irradiated rats against lethal effect of endotoxins in vivo}
author = {Budagov, R S, and Chureyeva, L N}
abstractNote = {The purpose of this work was to estimate protective properties of plasma in disease with increased endotoxemia. Burns and acute radiation sickness were used as models of suppression of physiological mechanisms of detoxication. Experiments were performed on male Wistar rats and mice, which received 3rd degree burns over 15% of the body surface, whole body gamma irradiation at 7.5 Gr or both. At 3 hours, 3, 7 and 12 days after the exposure the animals were decapitated and blood collected. The irradiated mice received 0.2 ml endotoxin intraperitoneally, 1.0 ml freshly prepared rat plasma, then the lethality of the mice in 24 hours was observed. It was found that the plasma of intact rats was capable of decreasing the lethal effects of S. typhimurium and E. coli endotoxins in vivo in mice. Deep skin burns, acute radiation sickness and the combined effects of radiation and thermal injury did not change this phenomenon. The plasma of the experimental rats retained the protective properties at various periods of time after the thermal, radiation and combined exposures. The functioning of the humoral detoxication mechanism is radioresistant, indirectly indicating the nonimmunoglobulin nature of endotoxin inactivators. 19 references.}
journal = {Zh. Mikrobiol., Epidemiol. Immunobiol.; (USSR)}
volume = {10}
journal type = {AC}
place = {USSR}
year = {1984}
month = {Oct}
}