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Experimental arsanilic acid poisoning in pigs

Journal Article:

Abstract

Twenty-one pigs were poisoned with rations containing 611, 1000 or 2000 g. arsanilic acid per ton. The chief symptoms were tremor of the head and incoordination followed by progressive blindness, ataxia and paresis. The only post-mortem abnormality was distension of the urinary bladder. The principal histological lesions were degeneration of the optic nerves, optic tracts and peripheral nerves, but such lesions could not be detected until about four, 10 and 14 days respectively after the onset of symptoms. The arsenic levels in various tissues were estimated. Concentrations in liver and kidney cortex were highest in the early stages of illness, two to 14 days after the onset of symptoms.
Publication Date:
Nov 30, 1968
Product Type:
Journal Article
Reference Number:
EDB-85-107489
Resource Relation:
Journal Name: Vet. Rec.; (United Kingdom); Journal Volume: 83
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ARSANILIC ACID; TISSUE DISTRIBUTION; TOXICITY; SWINE; INJURIES; DIET; DOSE-RESPONSE RELATIONSHIPS; KIDNEYS; LIVER; NERVOUS SYSTEM DISEASES; SYMPTOMS; AMINES; ANIMALS; ARSENIC COMPOUNDS; ARSONIC ACIDS; BODY; DIGESTIVE SYSTEM; DISEASES; DISTRIBUTION; DOMESTIC ANIMALS; GLANDS; MAMMALS; ORGANIC ACIDS; ORGANIC ARSENIC COMPOUNDS; ORGANIC COMPOUNDS; ORGANS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5650589
Research Organizations:
Central Veterinary Lab., Surrey, England
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: VETRA
Submitting Site:
HEDB
Size:
Pages: 560-564
Announcement Date:

Journal Article:

Citation Formats

Harding, J D.J., Lewis, G, and Done, J T. Experimental arsanilic acid poisoning in pigs. United Kingdom: N. p., 1968. Web.
Harding, J D.J., Lewis, G, & Done, J T. Experimental arsanilic acid poisoning in pigs. United Kingdom.
Harding, J D.J., Lewis, G, and Done, J T. 1968. "Experimental arsanilic acid poisoning in pigs." United Kingdom.
@misc{etde_5650589,
title = {Experimental arsanilic acid poisoning in pigs}
author = {Harding, J D.J., Lewis, G, and Done, J T}
abstractNote = {Twenty-one pigs were poisoned with rations containing 611, 1000 or 2000 g. arsanilic acid per ton. The chief symptoms were tremor of the head and incoordination followed by progressive blindness, ataxia and paresis. The only post-mortem abnormality was distension of the urinary bladder. The principal histological lesions were degeneration of the optic nerves, optic tracts and peripheral nerves, but such lesions could not be detected until about four, 10 and 14 days respectively after the onset of symptoms. The arsenic levels in various tissues were estimated. Concentrations in liver and kidney cortex were highest in the early stages of illness, two to 14 days after the onset of symptoms.}
journal = {Vet. Rec.; (United Kingdom)}
volume = {83}
journal type = {AC}
place = {United Kingdom}
year = {1968}
month = {Nov}
}