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Regional cerebral blood flow in the persistent vegetative state

Journal Article:

Abstract

Regional cerebral blood flow (CBF) in eight patients in a persistent vegetative state was measured and compared with that in five healthy volunteers. The patients were classified into three groups: Group 1 (locked-in syndrome) consisted of a single patient, Group 2 (typical vegetative state) of five patients, and Group 3 (prolonged coma) of two patients. CBF was measured early after onset by single photon emission computed tomography with {sup 123}I-N-isopropyl-p-iodo-amphetamine and/or {sup 99m}Tc-hexamethyl-propyleneamine oxime. The regions of interest (ROIs) were the bilateral frontal, temporal, parietal, occipital, and cerebellar areas and basal ganglia. The values obtained in these areas were averaged, and the ratio for each ROI ((the value in the ROI/the mean value) x 100) was calculated. 'Hyper-frontal distribution' of CBF was found to be rare in both the normal condition and the vegetative state. Higher CBF values were noted in the left than in the right frontal area in four of the five volunteers but in only four of the eight patients. CBF distribution in the frontal lobe was characteristic for each group: Group 1 showed high CBF bilaterally, although the elevation was statistically significant only on the right side, and Group 3 exhibited significantly low values. In Group  More>>
Authors:
Sato, Masaharu; Kuroda, Ryotaro; Ioku, Masahiko [1] 
  1. Kinki Univ., Osakasayama, Osaka (Japan). Faculty of Medicine; and others
Publication Date:
May 01, 1989
Product Type:
Journal Article
Reference Number:
JPN-89-013300; EDB-89-162338
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 29:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; BENZEDRINE; BLOOD FLOW; CAT SCANNING; IODINE 123; NERVOUS SYSTEM DISEASES; OXIMES; REFERENCE MAN; TECHNETIUM 99; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANS; RADIOISOTOPES; SYMPATHOMIMETICS; TECHNETIUM ISOTOPES; TOMOGRAPHY; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5640581
Country of Origin:
Japan
Language:
English
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 389-394
Announcement Date:

Journal Article:

Citation Formats

Sato, Masaharu, Kuroda, Ryotaro, and Ioku, Masahiko. Regional cerebral blood flow in the persistent vegetative state. Japan: N. p., 1989. Web.
Sato, Masaharu, Kuroda, Ryotaro, & Ioku, Masahiko. Regional cerebral blood flow in the persistent vegetative state. Japan.
Sato, Masaharu, Kuroda, Ryotaro, and Ioku, Masahiko. 1989. "Regional cerebral blood flow in the persistent vegetative state." Japan.
@misc{etde_5640581,
title = {Regional cerebral blood flow in the persistent vegetative state}
author = {Sato, Masaharu, Kuroda, Ryotaro, and Ioku, Masahiko}
abstractNote = {Regional cerebral blood flow (CBF) in eight patients in a persistent vegetative state was measured and compared with that in five healthy volunteers. The patients were classified into three groups: Group 1 (locked-in syndrome) consisted of a single patient, Group 2 (typical vegetative state) of five patients, and Group 3 (prolonged coma) of two patients. CBF was measured early after onset by single photon emission computed tomography with {sup 123}I-N-isopropyl-p-iodo-amphetamine and/or {sup 99m}Tc-hexamethyl-propyleneamine oxime. The regions of interest (ROIs) were the bilateral frontal, temporal, parietal, occipital, and cerebellar areas and basal ganglia. The values obtained in these areas were averaged, and the ratio for each ROI ((the value in the ROI/the mean value) x 100) was calculated. 'Hyper-frontal distribution' of CBF was found to be rare in both the normal condition and the vegetative state. Higher CBF values were noted in the left than in the right frontal area in four of the five volunteers but in only four of the eight patients. CBF distribution in the frontal lobe was characteristic for each group: Group 1 showed high CBF bilaterally, although the elevation was statistically significant only on the right side, and Group 3 exhibited significantly low values. In Group 2, CBF was variable but, for the most part, within normal limits. Awareness was closely correlated with frontal lobe function and alteration of CBF in the frontal region. (author).}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {29:5}
journal type = {AC}
place = {Japan}
year = {1989}
month = {May}
}