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Clinical assessment of mean washout time and lung functional image by ventilatory steady state measurement with /sup 133/Xe

Journal Article:

Abstract

Ventilatory steady state measurement with /sup 133/Xe, using Ventil-Con (Radx) and a large area scintillation camera (Searle, LFOV) combined with a mini-computer system (Shimadzu, Scintipac 230) was employed to evaluate regional pulmonary function of 94 patients with chronic obstructive lung disease (COLD), fibrosis, carcinoma and other lung diseases. In the patients with COLD, mean washout times (anti t) were markedly prolonged in whole lung fields (anti m 130 +- 33 sec.) and ventilation indices (V*/V) (*: radical) and perfusion indices (Q*/V) (*: radical) were reduced in regional zones, especially in bilateral lower lung zones. For the patients with lung fibrosis, anti t values were short and the distribution of ventilation indices were uniform, and in contrast perfusion indices were reduced in the lower lung fields. In the area most affected by carcinoma, lung volumes (V) were reduced in parallel with the regional ventilation (V*) (*: radical) and perfusion (Q*) (*: radical). As the tumor approached the hilum, the relative ventilation and perfusion of cancerous side decreased remarkably in patients with obstructive findings on bronchoscopy. The mean washout times (anti t) for /sup 133/Xe, calculated by a modified height over area method without background subtraction, were significantly longer than indicated by  More>>
Authors:
Kimura, K; Hasegawa, T; Watanabe, H; Hasegawa, S; Oshima, M [1] 
  1. Tsukuba Univ., Sakura, Ibaraki (Japan)
Publication Date:
Apr 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-661840; EDB-82-067281
Resource Relation:
Journal Name: Nihon Kyobu Shikkan Gakkai Zasshi; (Japan); Journal Volume: 19:4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; LUNGS; DYNAMIC FUNCTION STUDIES; SCINTISCANNING; RESPIRATORY SYSTEM DISEASES; DIAGNOSIS; BIOLOGICAL FUNCTIONS; CARCINOMAS; FIBROSIS; IMAGES; REFERENCE MAN; VENTILATION; XENON 133; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; EVEN-ODD NUCLEI; FUNCTIONS; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NEOPLASMS; NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM; XENON ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5639169
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NKYZA
Submitting Site:
INIS
Size:
Pages: 252-259
Announcement Date:

Journal Article:

Citation Formats

Kimura, K, Hasegawa, T, Watanabe, H, Hasegawa, S, and Oshima, M. Clinical assessment of mean washout time and lung functional image by ventilatory steady state measurement with /sup 133/Xe. Japan: N. p., 1981. Web.
Kimura, K, Hasegawa, T, Watanabe, H, Hasegawa, S, & Oshima, M. Clinical assessment of mean washout time and lung functional image by ventilatory steady state measurement with /sup 133/Xe. Japan.
Kimura, K, Hasegawa, T, Watanabe, H, Hasegawa, S, and Oshima, M. 1981. "Clinical assessment of mean washout time and lung functional image by ventilatory steady state measurement with /sup 133/Xe." Japan.
@misc{etde_5639169,
title = {Clinical assessment of mean washout time and lung functional image by ventilatory steady state measurement with /sup 133/Xe}
author = {Kimura, K, Hasegawa, T, Watanabe, H, Hasegawa, S, and Oshima, M}
abstractNote = {Ventilatory steady state measurement with /sup 133/Xe, using Ventil-Con (Radx) and a large area scintillation camera (Searle, LFOV) combined with a mini-computer system (Shimadzu, Scintipac 230) was employed to evaluate regional pulmonary function of 94 patients with chronic obstructive lung disease (COLD), fibrosis, carcinoma and other lung diseases. In the patients with COLD, mean washout times (anti t) were markedly prolonged in whole lung fields (anti m 130 +- 33 sec.) and ventilation indices (V*/V) (*: radical) and perfusion indices (Q*/V) (*: radical) were reduced in regional zones, especially in bilateral lower lung zones. For the patients with lung fibrosis, anti t values were short and the distribution of ventilation indices were uniform, and in contrast perfusion indices were reduced in the lower lung fields. In the area most affected by carcinoma, lung volumes (V) were reduced in parallel with the regional ventilation (V*) (*: radical) and perfusion (Q*) (*: radical). As the tumor approached the hilum, the relative ventilation and perfusion of cancerous side decreased remarkably in patients with obstructive findings on bronchoscopy. The mean washout times (anti t) for /sup 133/Xe, calculated by a modified height over area method without background subtraction, were significantly longer than indicated by the data yielded by the least squares curve fitting of initial washout curve after background subtraction. Although the accuracy of these data was limited, it appeared that the prolonged anti t is a good parameter of regional ventilatory disturbance because significant correlations were found between the whole lung anti t in patients with lung diseases and their FEV 1.0% r = -0.66, RV/TLC r = 0.64, % TLC r = 0.43, PaCO/sub 2/ r = 0.41, PaO/sub 2/ r = -0.35.}
journal = {Nihon Kyobu Shikkan Gakkai Zasshi; (Japan)}
volume = {19:4}
journal type = {AC}
place = {Japan}
year = {1981}
month = {Apr}
}