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Magnetic resonance imaging of experimental brain edema

Journal Article:

Abstract

Experimental brain edema was produced by either cold injury or TET (triethyl-tin) intoxication in twenty-five Wistar rats, weighing about 250 g each, and then analyzed using MRI (magnetic resonance imaging). The MRI was carried out with a 0.1 Tesla clinical apparatus (Asahi Mark J), using a special coil (7 cm in diameter) devised for small animals in order to obtain SR, SE, IR, and calculated T/sub 1/ and T/sub 2/ images. A dose of 0.5 mmol/kg of Gd-DTPA was injected intravenously for the cold-injury edema, and MRIs of the rat brains were started immediately and obtained successively for 3 hours. MRI showed spatial resolution sufficient to differentiate the cortex from the caudate nucleus, even in such a small rat brain. Rat brains with TET intoxication (cytotoxic edema) showed a marked prolongation of T/sub 1/ and T/sub 2/ in the white matter. Consequently, the TET-intoxication images reflected these characteristic findings. Cold-induced edema showed an increased signal intensity in the injured cortex, the white matter, and the opposite white matter when compared with a normal brain. These changes correlate well with the previously reported in vitro data. When Gd-DTPA was administered to the rats with cold-induced edema, the signal intensity of the  More>>
Publication Date:
Apr 01, 1987
Product Type:
Journal Article
Reference Number:
JPN-87-060382; EDB-88-021024
Resource Relation:
Journal Name: CT Kenkyu; (Japan); Journal Volume: 9:2
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; NMR IMAGING; DTPA; EDEMA; GADOLINIUM COMPOUNDS; IMAGES; RATS; RELAXATION TIME; SPATIAL RESOLUTION; SPIN-LATTICE RELAXATION; SPIN-SPIN RELAXATION; AMINO ACIDS; ANIMALS; BODY; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM; CHELATING AGENTS; DIAGNOSTIC TECHNIQUES; DRUGS; MAMMALS; NERVOUS SYSTEM; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RADIOPROTECTIVE SUBSTANCES; RARE EARTH COMPOUNDS; RELAXATION; RESOLUTION; RODENTS; SYMPTOMS; VERTEBRATES; 550602* - Medicine- External Radiation in Diagnostics- (1980-)
OSTI ID:
5626638
Research Organizations:
Kyoto Prefectural Univ. of Medicine, Japan
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: CTKED
Submitting Site:
JPN
Size:
Pages: 181-187
Announcement Date:

Journal Article:

Citation Formats

Tanaka, Chuzo, Naruse, Shoji, Horikawa, Yoshiharu, Higuchi, Toshihiro, Ebisu, Toshihiko, Hirakawa, Kimiyoshi, Ohno, Yoshioki, and Maki, Sou. Magnetic resonance imaging of experimental brain edema. Japan: N. p., 1987. Web.
Tanaka, Chuzo, Naruse, Shoji, Horikawa, Yoshiharu, Higuchi, Toshihiro, Ebisu, Toshihiko, Hirakawa, Kimiyoshi, Ohno, Yoshioki, & Maki, Sou. Magnetic resonance imaging of experimental brain edema. Japan.
Tanaka, Chuzo, Naruse, Shoji, Horikawa, Yoshiharu, Higuchi, Toshihiro, Ebisu, Toshihiko, Hirakawa, Kimiyoshi, Ohno, Yoshioki, and Maki, Sou. 1987. "Magnetic resonance imaging of experimental brain edema." Japan.
@misc{etde_5626638,
title = {Magnetic resonance imaging of experimental brain edema}
author = {Tanaka, Chuzo, Naruse, Shoji, Horikawa, Yoshiharu, Higuchi, Toshihiro, Ebisu, Toshihiko, Hirakawa, Kimiyoshi, Ohno, Yoshioki, and Maki, Sou}
abstractNote = {Experimental brain edema was produced by either cold injury or TET (triethyl-tin) intoxication in twenty-five Wistar rats, weighing about 250 g each, and then analyzed using MRI (magnetic resonance imaging). The MRI was carried out with a 0.1 Tesla clinical apparatus (Asahi Mark J), using a special coil (7 cm in diameter) devised for small animals in order to obtain SR, SE, IR, and calculated T/sub 1/ and T/sub 2/ images. A dose of 0.5 mmol/kg of Gd-DTPA was injected intravenously for the cold-injury edema, and MRIs of the rat brains were started immediately and obtained successively for 3 hours. MRI showed spatial resolution sufficient to differentiate the cortex from the caudate nucleus, even in such a small rat brain. Rat brains with TET intoxication (cytotoxic edema) showed a marked prolongation of T/sub 1/ and T/sub 2/ in the white matter. Consequently, the TET-intoxication images reflected these characteristic findings. Cold-induced edema showed an increased signal intensity in the injured cortex, the white matter, and the opposite white matter when compared with a normal brain. These changes correlate well with the previously reported in vitro data. When Gd-DTPA was administered to the rats with cold-induced edema, the signal intensity of the cold-injury lesion was significantly reduced. These changes were clearly demonstrated by the calculated T/sub 1/ images. To two rats we administered a dose of 0.5 mmol/kg of Gd-DTPA; The T/sub 1/ values for the cold-injury lesions, before and after the injection, were about 445 msec and about 200 msec respectively. These studies were useful not only in evaluating brain edema, but also in analysing the effect of Gd-DTPA on the brain edema.}
journal = {CT Kenkyu; (Japan)}
volume = {9:2}
journal type = {AC}
place = {Japan}
year = {1987}
month = {Apr}
}