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Radioimmunoassay of erythropoietin

Journal Article:

Abstract

A brief review of the historical development of the radioimmunoassay (RIA) for serum erythropoietin is given. It has been shown that there is reasonable agreement between the results obtained by RIA and those obtained by the previously used bioassay. By RIA, a mean normal serum titre of 18 mu/ml erythropoietin has been determined in a study of 445 individuals. Serum erythropoietin results for patients with polycythaemia vera have not been shown to be significantly different from normal values but in patients with secondary polycythaemia, serum titres averaging 94 mu/ml have been found. The predicted physiological changes in erythropoietin titre have also been demonstrated in humans using the RIA; increasing after bleeding and decreasing after red cell administration. Studies of erythropoietin levels in experimental animals have shown that, with the particular antiserum used, the sensitivity of the RIA is markedly reduced.
Authors:
Goldwasser, E; Sherwood, J B [1] 
  1. Chicago Univ., IL (USA). Dept. of Biochemistry
Publication Date:
Jul 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-659059; EDB-82-073309
Resource Relation:
Journal Name: Br. J. Haematol.; (United Kingdom); Journal Volume: 48:3
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD SERUM; ERYTHROPOIETIN; RADIOIMMUNOASSAY; ANIMALS; DISEASES; DOCUMENT TYPES; HEMIC DISEASES; ISOTOPE APPLICATIONS; MAMMALS; PRIMATES; RADIOASSAY; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5614709
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJHEA
Submitting Site:
INIS
Size:
Pages: 359-363
Announcement Date:
Mar 01, 1982

Journal Article:

Citation Formats

Goldwasser, E, and Sherwood, J B. Radioimmunoassay of erythropoietin. United Kingdom: N. p., 1981. Web.
Goldwasser, E, & Sherwood, J B. Radioimmunoassay of erythropoietin. United Kingdom.
Goldwasser, E, and Sherwood, J B. 1981. "Radioimmunoassay of erythropoietin." United Kingdom.
@misc{etde_5614709,
title = {Radioimmunoassay of erythropoietin}
author = {Goldwasser, E, and Sherwood, J B}
abstractNote = {A brief review of the historical development of the radioimmunoassay (RIA) for serum erythropoietin is given. It has been shown that there is reasonable agreement between the results obtained by RIA and those obtained by the previously used bioassay. By RIA, a mean normal serum titre of 18 mu/ml erythropoietin has been determined in a study of 445 individuals. Serum erythropoietin results for patients with polycythaemia vera have not been shown to be significantly different from normal values but in patients with secondary polycythaemia, serum titres averaging 94 mu/ml have been found. The predicted physiological changes in erythropoietin titre have also been demonstrated in humans using the RIA; increasing after bleeding and decreasing after red cell administration. Studies of erythropoietin levels in experimental animals have shown that, with the particular antiserum used, the sensitivity of the RIA is markedly reduced.}
journal = {Br. J. Haematol.; (United Kingdom)}
volume = {48:3}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Jul}
}