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New horizons in radiation oncology

Abstract

This article describes the contributions of physics and radiobiology to the 'growing points' in the treatment of cancer by radiotherapy. Possible new methods of achieving better physical dose distributions in tissues and also improvements in diagnostic and prognostic tumour detection techniques are briefly discussed. The successes of using multiple-small-doses (hyperfractionation) of X-rays are reported; this is thought to be due to differing effects on the repair mechanism of tumour cells. The emphasis of the article is on the methods of overcoming the greater resistance to X-rays of hypoxic cells present in tumours. These include the use of hyperbaric oxygen, fast neutrons, negative pi mesons, heavy particle beams and hypoxic cell radiosensitizers. The effect of fractionation of X-rays, neutrons and radiosensitizers on tumour control are also discussed in relation to the effects on hypoxic cells subjected to hyperthermia following X-irradiation are reported. Combination treatments of radiotherapy and chemotherapy are briefly discussed. Finally, a summary of the estimates of the gain in cell kill in cancer treatment using various modalities is given; the elimination of hypoxic cells appears to be the largest effect, followed by hyperthermia.
Authors:
Fowler, J F [1] 
  1. Mount Vernon Hospital, Northwood (UK). Gray Lab.
Publication Date:
Jul 01, 1979
Product Type:
Conference
Reference Number:
AIX-10-494592; EDB-80-037279
Resource Relation:
Journal Name: Br. J. Radiol.; (United Kingdom); Journal Volume: 52:619; Conference: British Institute of Radiology joint meeting and annual congress, London, UK, 13 Apr 1978
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; NEOPLASMS; RADIOTHERAPY; RADIOSENSITIVITY; ANOXIA; BIOLOGICAL RADIATION EFFECTS; BIOLOGICAL REPAIR; BODY TEMPERATURE; CHEMOTHERAPY; DATA COMPILATION; EXPERIMENTAL DATA; FRACTIONATED IRRADIATION; GRAPHS; LET; MAN; METRONIDAZOLE; MICE; NEUTRON THERAPY; OXYGEN; OXYGEN ENHANCEMENT RATIO; PION BEAMS; RADIATION DOSE DISTRIBUTIONS; RADIOSENSITIZERS; RBE; TABLES; THEORETICAL DATA; TUMOR CELLS; X RADIATION; ALCOHOLS; ANIMAL CELLS; ANIMALS; AZOLES; BEAMS; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; CRYOGENIC FLUIDS; DATA; DATA FORMS; DISEASES; DRUGS; ELECTROMAGNETIC RADIATION; ELEMENTS; ENERGY TRANSFER; FLUIDS; HETEROCYCLIC COMPOUNDS; HYDROXY COMPOUNDS; IMIDAZOLES; INFORMATION; IONIZING RADIATIONS; IRRADIATION; MAMMALS; MEDICINE; MESON BEAMS; NITRO COMPOUNDS; NONMETALS; NUCLEAR MEDICINE; NUMERICAL DATA; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; PARTICLE BEAMS; PRIMATES; RADIATION EFFECTS; RADIATIONS; RADIOLOGY; RECOVERY; REPAIR; RESPONSE MODIFYING FACTORS; RODENTS; THERAPY; VERTEBRATES; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)
OSTI ID:
5610652
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BJRAA
Submitting Site:
INIS
Size:
Pages: 523-535
Announcement Date:

Citation Formats

Fowler, J F. New horizons in radiation oncology. United Kingdom: N. p., 1979. Web.
Fowler, J F. New horizons in radiation oncology. United Kingdom.
Fowler, J F. 1979. "New horizons in radiation oncology." United Kingdom.
@misc{etde_5610652,
title = {New horizons in radiation oncology}
author = {Fowler, J F}
abstractNote = {This article describes the contributions of physics and radiobiology to the 'growing points' in the treatment of cancer by radiotherapy. Possible new methods of achieving better physical dose distributions in tissues and also improvements in diagnostic and prognostic tumour detection techniques are briefly discussed. The successes of using multiple-small-doses (hyperfractionation) of X-rays are reported; this is thought to be due to differing effects on the repair mechanism of tumour cells. The emphasis of the article is on the methods of overcoming the greater resistance to X-rays of hypoxic cells present in tumours. These include the use of hyperbaric oxygen, fast neutrons, negative pi mesons, heavy particle beams and hypoxic cell radiosensitizers. The effect of fractionation of X-rays, neutrons and radiosensitizers on tumour control are also discussed in relation to the effects on hypoxic cells subjected to hyperthermia following X-irradiation are reported. Combination treatments of radiotherapy and chemotherapy are briefly discussed. Finally, a summary of the estimates of the gain in cell kill in cancer treatment using various modalities is given; the elimination of hypoxic cells appears to be the largest effect, followed by hyperthermia.}
journal = {Br. J. Radiol.; (United Kingdom)}
volume = {52:619}
place = {United Kingdom}
year = {1979}
month = {Jul}
}