Abstract
An analysis of the data on the effect of lymphoid cells on the proliferation and differentiation of hemopoietic stem cells has led to a conclusion that radiation injury of lymphocytes plays an important role in the pathogenesis of the cerebrospinal syndrome. The molecular mechanisms of lymphocyte interphase death were considered. It was shown that due to some peculiarities in the energy supply of these' cells the appearance of breaks in DNA causes the development of biochemical processes resulting in a decrease in NAD, an increase in the activity of nucleases, a decrease in ATP, and the accumulation of active metabolites of glycolysis. There reactions result in an increase in the disintegration of DNA, chromatin and pyknosis of lymphocyte nuclei.
Citation Formats
Poverennyj, A M, and Ryabchenko, N I.
Interphase lymphoid cell death: its importance in the genesis of radiation disease and molecular mechanisms.
USSR: N. p.,
1987.
Web.
Poverennyj, A M, & Ryabchenko, N I.
Interphase lymphoid cell death: its importance in the genesis of radiation disease and molecular mechanisms.
USSR.
Poverennyj, A M, and Ryabchenko, N I.
1987.
"Interphase lymphoid cell death: its importance in the genesis of radiation disease and molecular mechanisms."
USSR.
@misc{etde_5606537,
title = {Interphase lymphoid cell death: its importance in the genesis of radiation disease and molecular mechanisms}
author = {Poverennyj, A M, and Ryabchenko, N I}
abstractNote = {An analysis of the data on the effect of lymphoid cells on the proliferation and differentiation of hemopoietic stem cells has led to a conclusion that radiation injury of lymphocytes plays an important role in the pathogenesis of the cerebrospinal syndrome. The molecular mechanisms of lymphocyte interphase death were considered. It was shown that due to some peculiarities in the energy supply of these' cells the appearance of breaks in DNA causes the development of biochemical processes resulting in a decrease in NAD, an increase in the activity of nucleases, a decrease in ATP, and the accumulation of active metabolites of glycolysis. There reactions result in an increase in the disintegration of DNA, chromatin and pyknosis of lymphocyte nuclei.}
journal = []
volume = {32:9}
journal type = {AC}
place = {USSR}
year = {1987}
month = {Sep}
}
title = {Interphase lymphoid cell death: its importance in the genesis of radiation disease and molecular mechanisms}
author = {Poverennyj, A M, and Ryabchenko, N I}
abstractNote = {An analysis of the data on the effect of lymphoid cells on the proliferation and differentiation of hemopoietic stem cells has led to a conclusion that radiation injury of lymphocytes plays an important role in the pathogenesis of the cerebrospinal syndrome. The molecular mechanisms of lymphocyte interphase death were considered. It was shown that due to some peculiarities in the energy supply of these' cells the appearance of breaks in DNA causes the development of biochemical processes resulting in a decrease in NAD, an increase in the activity of nucleases, a decrease in ATP, and the accumulation of active metabolites of glycolysis. There reactions result in an increase in the disintegration of DNA, chromatin and pyknosis of lymphocyte nuclei.}
journal = []
volume = {32:9}
journal type = {AC}
place = {USSR}
year = {1987}
month = {Sep}
}