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Treatment of hyperthyroidism with /sup 131/I

Abstract

/sup 131/I therapy for hyperthyroidism is limited to those over middle age, women who do not want to bear a child, those in whom drugs are ineffective, those who relapse after operation, and those with severe complications. As to young patients, this therapy is limited to those in whom drugs of operation is ineffective. Basic line of absorbed doses is 5,000 rad. As to histological and immunological changes in the thyroid gland after this therapy, a relationship between pathogenesis of hypothyroidism and immunological mechanism must be discussed in future. The recovery rate of hyperthyroidism by this therapy was high (60 - 95%). The reported incidences of hypothyroidism after this therapy for 10 years were 12%, 15%, 29% and 67%. The maximum fault in this therapy is to induce hypothyroidism. Though the incidences of thyroid cancer, leukemia, and malformation after this therapy are not different from their spontaneous occurrence rates, clinical cases must be followed and observed strictly in future. Excepting this therapy, antithyroid drugs and operation are effective for this disease. Therefore, the therapy which is the most advantageous for the patients must be performed.
Authors:
Nakamura, I; [1]  Tsuchikame, N; Katayama, K
  1. Kumamoto Univ. (Japan)
Publication Date:
May 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-13-675495; EDB-82-090578
Resource Relation:
Journal Name: Rinsho To Kenkyu; (Japan); Journal Volume: 57:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HYPERTHYROIDISM; RADIOTHERAPY; IODINE 131; TOXICITY; SIDE EFFECTS; BIBLIOGRAPHIES; CARCINOGENESIS; GENETIC RADIATION EFFECTS; HYPOTHYROIDISM; LEUKEMOGENESIS; RADIATION DOSES; REVIEWS; THYROID; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DAYS LIVING RADIOISOTOPES; DISEASES; DOCUMENT TYPES; DOSES; ENDOCRINE DISEASES; ENDOCRINE GLANDS; GENETIC EFFECTS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANS; PATHOGENESIS; RADIATION EFFECTS; RADIOISOTOPES; RADIOLOGY; THERAPY; 550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-); 560161 - Radionuclide Effects, Kinetics, & Toxicology- Man
OSTI ID:
5579796
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: RIKEA
Submitting Site:
HEDB
Size:
Pages: 1511-1517
Announcement Date:
May 01, 1982

Citation Formats

Nakamura, I, Tsuchikame, N, and Katayama, K. Treatment of hyperthyroidism with /sup 131/I. Japan: N. p., 1980. Web.
Nakamura, I, Tsuchikame, N, & Katayama, K. Treatment of hyperthyroidism with /sup 131/I. Japan.
Nakamura, I, Tsuchikame, N, and Katayama, K. 1980. "Treatment of hyperthyroidism with /sup 131/I." Japan.
@misc{etde_5579796,
title = {Treatment of hyperthyroidism with /sup 131/I}
author = {Nakamura, I, Tsuchikame, N, and Katayama, K}
abstractNote = {/sup 131/I therapy for hyperthyroidism is limited to those over middle age, women who do not want to bear a child, those in whom drugs are ineffective, those who relapse after operation, and those with severe complications. As to young patients, this therapy is limited to those in whom drugs of operation is ineffective. Basic line of absorbed doses is 5,000 rad. As to histological and immunological changes in the thyroid gland after this therapy, a relationship between pathogenesis of hypothyroidism and immunological mechanism must be discussed in future. The recovery rate of hyperthyroidism by this therapy was high (60 - 95%). The reported incidences of hypothyroidism after this therapy for 10 years were 12%, 15%, 29% and 67%. The maximum fault in this therapy is to induce hypothyroidism. Though the incidences of thyroid cancer, leukemia, and malformation after this therapy are not different from their spontaneous occurrence rates, clinical cases must be followed and observed strictly in future. Excepting this therapy, antithyroid drugs and operation are effective for this disease. Therefore, the therapy which is the most advantageous for the patients must be performed.}
journal = []
volume = {57:5}
journal type = {AC}
place = {Japan}
year = {1980}
month = {May}
}