Abstract
Objective: To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the anti-radiation effect. Methods: Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized. The drug was administered to mice before 9.03 Gy {sup 60}Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results: Most of these compounds showed significant radioprotective effects. Among them, DMTD tartrate 250 mg/kg given i.p. 1 hour before irradiation increased the survival rate by 40%. Cystamine succinate 250 mg/kg administered i.p. 15 min. before irradiation increased the survival rate by 77.5%. Conclusion: Cystamine succinate showed marked anti-radiation effect. Further investigation is worthwhile.
Rongxian, Wang;
Meijia, Li;
Xianglian, Zhuang
[1]
- Chinese Academy of Medical Sciences, TJ (China); and others
Citation Formats
Rongxian, Wang, Meijia, Li, and Xianglian, Zhuang.
Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine.
China: N. p.,
1997.
Web.
Rongxian, Wang, Meijia, Li, & Xianglian, Zhuang.
Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine.
China.
Rongxian, Wang, Meijia, Li, and Xianglian, Zhuang.
1997.
"Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine."
China.
@misc{etde_557332,
title = {Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine}
author = {Rongxian, Wang, Meijia, Li, and Xianglian, Zhuang}
abstractNote = {Objective: To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the anti-radiation effect. Methods: Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized. The drug was administered to mice before 9.03 Gy {sup 60}Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results: Most of these compounds showed significant radioprotective effects. Among them, DMTD tartrate 250 mg/kg given i.p. 1 hour before irradiation increased the survival rate by 40%. Cystamine succinate 250 mg/kg administered i.p. 15 min. before irradiation increased the survival rate by 77.5%. Conclusion: Cystamine succinate showed marked anti-radiation effect. Further investigation is worthwhile.}
journal = []
issue = {4}
volume = {17}
journal type = {AC}
place = {China}
year = {1997}
month = {Aug}
}
title = {Synthesis and radioprotective effects of organic salts of 2,2-dimethylthiazolidine and cystamine}
author = {Rongxian, Wang, Meijia, Li, and Xianglian, Zhuang}
abstractNote = {Objective: To improve physical and chemical properties of 2,2-dimethylthiazolidine hydrochloride (DMTD) and enhance the anti-radiation effect. Methods: Various organic salts of 2,2-dimethylthiazolidine and cystamine were synthesized. The drug was administered to mice before 9.03 Gy {sup 60}Co gamma-ray whole body irradiation for evaluation of radioprotective effects. Results: Most of these compounds showed significant radioprotective effects. Among them, DMTD tartrate 250 mg/kg given i.p. 1 hour before irradiation increased the survival rate by 40%. Cystamine succinate 250 mg/kg administered i.p. 15 min. before irradiation increased the survival rate by 77.5%. Conclusion: Cystamine succinate showed marked anti-radiation effect. Further investigation is worthwhile.}
journal = []
issue = {4}
volume = {17}
journal type = {AC}
place = {China}
year = {1997}
month = {Aug}
}