You need JavaScript to view this

Sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-tyr-somatostatin as labelled antigen

Journal Article:

Abstract

A sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-Tyr-somatostatin is described and compared with using (/sup 125/I)-Tyr/sup 1/-somatostatin. The minimum detectable amount of somatostatin using N-(/sup 125/I)-Tyr-somatostatin as tracer was 0.1 to 0.5 pg, which is approximately 10-fold lower detection limit of the RIA using (/sup 125/I)-Tyr/sup 1/-somatostatin. Moreover, it was found that the shelf-life of N-(/sup 125/I)-Tyr-somatostatin was prolonged in comparison with labelled Tyr/sup 1/-somatostatin. Human pancreatic and gastric extracts displayed immunological similarity to synthetic somatostatin tetradecapeptide.
Authors:
Dupont, A; [1]  Coy, D H; Alvarado-Urbina, G; Cote, J; Meyers, C A; McManus, J; Barden, N; De Lean, A; Labrie, F
  1. CHUL, Quebec (Canada). Lab. of Molecular Endocrinology and Service of Gastro-Enterology
Publication Date:
Jan 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-10-473161; EDB-80-024215
Resource Relation:
Journal Name: Clin. Endocrinol. (Oxford); (United Kingdom); Journal Volume: 10:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; PEPTIDE HORMONES; RADIOIMMUNOASSAY; ANTIGENS; DECOMPOSITION; EXPERIMENTAL DATA; GRAPHS; IODINE 125; LABELLED COMPOUNDS; MOLECULAR STRUCTURE; SENSITIVITY; STORAGE; TABLES; TYROSINE; AMINO ACIDS; BETA DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CHEMICAL REACTIONS; DATA; DATA FORMS; DAYS LIVING RADIOISOTOPES; ELECTRON CAPTURE RADIOISOTOPES; HORMONES; HYDROXY ACIDS; INFORMATION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; NUCLEI; NUMERICAL DATA; ODD-EVEN NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; RADIOASSAY; RADIOISOTOPES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5572292
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: CLECA
Submitting Site:
INIS
Size:
Pages: 47-54
Announcement Date:

Journal Article:

Citation Formats

Dupont, A, Coy, D H, Alvarado-Urbina, G, Cote, J, Meyers, C A, McManus, J, Barden, N, De Lean, A, and Labrie, F. Sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-tyr-somatostatin as labelled antigen. United Kingdom: N. p., 1979. Web.
Dupont, A, Coy, D H, Alvarado-Urbina, G, Cote, J, Meyers, C A, McManus, J, Barden, N, De Lean, A, & Labrie, F. Sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-tyr-somatostatin as labelled antigen. United Kingdom.
Dupont, A, Coy, D H, Alvarado-Urbina, G, Cote, J, Meyers, C A, McManus, J, Barden, N, De Lean, A, and Labrie, F. 1979. "Sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-tyr-somatostatin as labelled antigen." United Kingdom.
@misc{etde_5572292,
title = {Sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-tyr-somatostatin as labelled antigen}
author = {Dupont, A, Coy, D H, Alvarado-Urbina, G, Cote, J, Meyers, C A, McManus, J, Barden, N, De Lean, A, and Labrie, F}
abstractNote = {A sensitive radioimmunoassay for somatostatin using N-(/sup 125/I)-Tyr-somatostatin is described and compared with using (/sup 125/I)-Tyr/sup 1/-somatostatin. The minimum detectable amount of somatostatin using N-(/sup 125/I)-Tyr-somatostatin as tracer was 0.1 to 0.5 pg, which is approximately 10-fold lower detection limit of the RIA using (/sup 125/I)-Tyr/sup 1/-somatostatin. Moreover, it was found that the shelf-life of N-(/sup 125/I)-Tyr-somatostatin was prolonged in comparison with labelled Tyr/sup 1/-somatostatin. Human pancreatic and gastric extracts displayed immunological similarity to synthetic somatostatin tetradecapeptide.}
journal = {Clin. Endocrinol. (Oxford); (United Kingdom)}
volume = {10:1}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Jan}
}