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Interferon induction by adenoviruses

Journal Article:

Abstract

All human, simian, bovine and avian adenovirus types tested so far and the canine hepatitis virus induce interferon production in chick cells. This finding indicated this property to be characteristic for viruses belonging to the adenovirus group. Trypsin treatment, which had no effect upon the infectivity, diminished or eliminated the interferon-inducing abilities of crude adenoviruses, and thus the need for a trypsin-sensitive protein in interferon induction was suggested. T antigen and interferon were formed simultaneously in chick embryo fibroblast cells infected with human adenovirus type 12, and there-fore the adenovirus-specific T antigen was resitant to the action of endogenous interferon synthetized by the same cells. In chicks inoculated with human types, the appearance of interferon was biphasic: an 'early' and a 'late' interferon could be demonstrated with maximum titre 4 and 10 hr, respectively, after virus infection. In chicks infected with adenoviruses, first interferon production and then a decreased primary immune response to sheep red blood cells was observed. It was assumed that in adenovirus-infected chicks the interferon produced by viral stimulus resulted in a transient immunosuppression.
Authors:
Beladi, I; Bakay, M; Pusztai, R; Mucsi, I; Tarodi, B [1] 
  1. University Medical School, Szeged (Hungary). Inst. of Microbiology
Publication Date:
Feb 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-10-472900; EDB-80-024387
Resource Relation:
Journal Name: Postgrad. Med. J.; (United Kingdom); Journal Volume: 55:640
Subject:
59 BASIC BIOLOGICAL SCIENCES; ADENOVIRUS; INTERFERON; ANIMAL CELLS; ANTIGENS; CHICKENS; EXPERIMENTAL DATA; IMMUNOSUPPRESSION; TABLES; TRYPSIN; ANIMALS; BIRDS; DATA; DATA FORMS; ENZYMES; FOWL; HYDROLASES; INFORMATION; MICROORGANISMS; NUMERICAL DATA; ONCOGENIC VIRUSES; PARASITES; PEPTIDE HYDROLASES; VERTEBRATES; VIRUSES; 550701* - Microbiology- Tracer Techniques
OSTI ID:
5571877
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PGMJA
Submitting Site:
INIS
Size:
Pages: 128-134
Announcement Date:

Journal Article:

Citation Formats

Beladi, I, Bakay, M, Pusztai, R, Mucsi, I, and Tarodi, B. Interferon induction by adenoviruses. United Kingdom: N. p., 1979. Web.
Beladi, I, Bakay, M, Pusztai, R, Mucsi, I, & Tarodi, B. Interferon induction by adenoviruses. United Kingdom.
Beladi, I, Bakay, M, Pusztai, R, Mucsi, I, and Tarodi, B. 1979. "Interferon induction by adenoviruses." United Kingdom.
@misc{etde_5571877,
title = {Interferon induction by adenoviruses}
author = {Beladi, I, Bakay, M, Pusztai, R, Mucsi, I, and Tarodi, B}
abstractNote = {All human, simian, bovine and avian adenovirus types tested so far and the canine hepatitis virus induce interferon production in chick cells. This finding indicated this property to be characteristic for viruses belonging to the adenovirus group. Trypsin treatment, which had no effect upon the infectivity, diminished or eliminated the interferon-inducing abilities of crude adenoviruses, and thus the need for a trypsin-sensitive protein in interferon induction was suggested. T antigen and interferon were formed simultaneously in chick embryo fibroblast cells infected with human adenovirus type 12, and there-fore the adenovirus-specific T antigen was resitant to the action of endogenous interferon synthetized by the same cells. In chicks inoculated with human types, the appearance of interferon was biphasic: an 'early' and a 'late' interferon could be demonstrated with maximum titre 4 and 10 hr, respectively, after virus infection. In chicks infected with adenoviruses, first interferon production and then a decreased primary immune response to sheep red blood cells was observed. It was assumed that in adenovirus-infected chicks the interferon produced by viral stimulus resulted in a transient immunosuppression.}
journal = {Postgrad. Med. J.; (United Kingdom)}
volume = {55:640}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Feb}
}