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Differential diagnosis in patients with extrapyramidal movement disorders: [sup 123]I-IBZM-SPECT vs. apomorphine-test. Differentialdiagnose der Parkinson-Erkrankungen - [sup 123]I-IBZM-SPECT vs. Apomorphin-Test

Journal Article:

Abstract

The aim of our study was to compare the striatal dopamine D2-receptor density as measured by [sup 123]I-IBZM-SPECT with the results of the apomorphine-test. 30 patients were studied; 21 with idiopathic Parkinson's disease (IPD), 9 with Parkinson plus syndromes (PPS). Patients with IPD showed a significantly higher striatal IBZM binding as compared to patients with PPS (p=0.006). A good correlation between IBZM binding and outcome of the apomorphine test was found (p=0.006). Low striatal IBZM binding indicates reduced dopamine D2-receptor density. This compromises successful dopaminergic medical therapy and is indicative of non-IPD disease. [sup 123]I-IBZM-SPECT could be diagnostic aid in the work-up of patients with extrapyramidal movement disorders. The response to dopaminergic drug treatment might be precluded by IBZM-SPECT in patients with Parkinsonian syndromes. (orig.)
Authors:
Hierholzer, J; [1]  Cordes, M; [1]  Schelosky, L; [2]  Sander, B; [1]  Boeck, J C; [1]  David, I; [1]  Horowski, R; [3]  Poewe, W [2] 
  1. Strahlenklinik und Poliklinik, Klinikum Rudolf Virchow, Freie Univ. Berlin (Germany)
  2. Neurologische Klinik und Poliklinik, Klinikum Rudolf Virchow, Freie Univ. Berlin (Germany)
  3. Schering AG, Berlin (Germany)
Publication Date:
Jul 01, 1993
Product Type:
Journal Article
Reference Number:
DEN-94-0F0181; EDB-94-026987
Resource Relation:
Journal Name: RoeFo - Fortschritte auf dem Gebiete der Roentgenstrahlen und der Nuklearmedizin; (Germany); Journal Volume: 159:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; GANGLIONS; BIOMEDICAL RADIOGRAPHY; NERVOUS SYSTEM DISEASES; DIAGNOSIS; DOPAMINE; IMAGES; IODINE 123; NUMERICAL DATA; PATIENTS; RECEPTORS; SPECTROSCOPY; AMINES; AROMATICS; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; CARDIOTONICS; CARDIOVASCULAR AGENTS; DATA; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; HOURS LIVING RADIOISOTOPES; HYDROXY COMPOUNDS; INFORMATION; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MEDICINE; MEMBRANE PROTEINS; NERVOUS SYSTEM; NEUROREGULATORS; NUCLEAR MEDICINE; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; PHENOLS; POLYPHENOLS; PROTEINS; RADIOISOTOPES; RADIOLOGY; SYMPATHOMIMETICS; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5570183
Country of Origin:
Germany
Language:
German
Other Identifying Numbers:
Journal ID: ISSN 0340-1618; CODEN: RFGNDO
Submitting Site:
DEN
Size:
Pages: 86-90
Announcement Date:

Journal Article:

Citation Formats

Hierholzer, J, Cordes, M, Schelosky, L, Sander, B, Boeck, J C, David, I, Horowski, R, and Poewe, W. Differential diagnosis in patients with extrapyramidal movement disorders: [sup 123]I-IBZM-SPECT vs. apomorphine-test. Differentialdiagnose der Parkinson-Erkrankungen - [sup 123]I-IBZM-SPECT vs. Apomorphin-Test. Germany: N. p., 1993. Web.
Hierholzer, J, Cordes, M, Schelosky, L, Sander, B, Boeck, J C, David, I, Horowski, R, & Poewe, W. Differential diagnosis in patients with extrapyramidal movement disorders: [sup 123]I-IBZM-SPECT vs. apomorphine-test. Differentialdiagnose der Parkinson-Erkrankungen - [sup 123]I-IBZM-SPECT vs. Apomorphin-Test. Germany.
Hierholzer, J, Cordes, M, Schelosky, L, Sander, B, Boeck, J C, David, I, Horowski, R, and Poewe, W. 1993. "Differential diagnosis in patients with extrapyramidal movement disorders: [sup 123]I-IBZM-SPECT vs. apomorphine-test. Differentialdiagnose der Parkinson-Erkrankungen - [sup 123]I-IBZM-SPECT vs. Apomorphin-Test." Germany.
@misc{etde_5570183,
title = {Differential diagnosis in patients with extrapyramidal movement disorders: [sup 123]I-IBZM-SPECT vs. apomorphine-test. Differentialdiagnose der Parkinson-Erkrankungen - [sup 123]I-IBZM-SPECT vs. Apomorphin-Test}
author = {Hierholzer, J, Cordes, M, Schelosky, L, Sander, B, Boeck, J C, David, I, Horowski, R, and Poewe, W}
abstractNote = {The aim of our study was to compare the striatal dopamine D2-receptor density as measured by [sup 123]I-IBZM-SPECT with the results of the apomorphine-test. 30 patients were studied; 21 with idiopathic Parkinson's disease (IPD), 9 with Parkinson plus syndromes (PPS). Patients with IPD showed a significantly higher striatal IBZM binding as compared to patients with PPS (p=0.006). A good correlation between IBZM binding and outcome of the apomorphine test was found (p=0.006). Low striatal IBZM binding indicates reduced dopamine D2-receptor density. This compromises successful dopaminergic medical therapy and is indicative of non-IPD disease. [sup 123]I-IBZM-SPECT could be diagnostic aid in the work-up of patients with extrapyramidal movement disorders. The response to dopaminergic drug treatment might be precluded by IBZM-SPECT in patients with Parkinsonian syndromes. (orig.)}
journal = {RoeFo - Fortschritte auf dem Gebiete der Roentgenstrahlen und der Nuklearmedizin; (Germany)}
volume = {159:1}
journal type = {AC}
place = {Germany}
year = {1993}
month = {Jul}
}