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Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia or rats

Abstract

Previous studies using radioimmunoassay procedures have failed to show age-related changes in the concentration of Met-and Leu-enkephalin or neurotensin in rat basal ganglia. In contrast, using a combined high-pressure liquid chromatography (HLPC)- radioimmunoassay (RIA) technique we now report considerable decreases in the levels of these neuropeptides in areas of basal ganglia of 22 months-old compared to 3 months-old male Wistar rats. The concentration of Met-enkephalin was greatly reduced in the striatum and nucleus accumbens, but not in substantia nigra, of old compared to young animals. There was a similarly large decrease in Leu-enkephalin content in striatum of old rats with less marked decreases occurring in both the nucleus accumbens and substantia nigra. Neurotensin levels in the striatum and substantia nigra were greatly reduced in old rats, with a less marked decrease in the nucleus accumbens.
Publication Date:
Mar 20, 1987
Product Type:
Journal Article
Reference Number:
AIX-19-022901; EDB-88-052031
Resource Relation:
Journal Name: Neurosci. Lett.; (Ireland); Journal Volume: 75:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; ENKEPHALINS; RADIOIMMUNOASSAY; RATS; AGE DEPENDENCE; BRAIN; DETECTION; GANGLIONS; LIQUID COLUMN CHROMATOGRAPHY; QUANTITY RATIO; ANIMALS; AUTONOMIC NERVOUS SYSTEM AGENTS; BODY; CENTRAL NERVOUS SYSTEM; CHROMATOGRAPHY; DRUGS; ENDORPHINS; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; MAMMALS; NERVOUS SYSTEM; NEUROREGULATORS; ORGANIC COMPOUNDS; ORGANS; PEPTIDES; POLYPEPTIDES; PROTEINS; RADIOASSAY; RADIOIMMUNOLOGY; RODENTS; SEPARATION PROCESSES; TRACER TECHNIQUES; VERTEBRATES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5548086
Research Organizations:
Institute of Psychiatry and King's Coll. Hospital Medical School, London, UK. Univ. Dept. of Neurology and Parkinson's Disease Society Research Centre
Country of Origin:
Ireland
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: NELED
Submitting Site:
INIS
Size:
Pages: 113-117
Announcement Date:

Citation Formats

Ceballos, M.L. de, Boyce, S, Taylor, M, Jenner, P, and Marsden, C D. Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia or rats. Ireland: N. p., 1987. Web. doi:10.1016/0304-3940(87)90085-1.
Ceballos, M.L. de, Boyce, S, Taylor, M, Jenner, P, & Marsden, C D. Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia or rats. Ireland. doi:10.1016/0304-3940(87)90085-1.
Ceballos, M.L. de, Boyce, S, Taylor, M, Jenner, P, and Marsden, C D. 1987. "Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia or rats." Ireland. doi:10.1016/0304-3940(87)90085-1. https://www.osti.gov/servlets/purl/10.1016/0304-3940(87)90085-1.
@misc{etde_5548086,
title = {Age-related decreases in the concentration of Met- and Leu-enkephalin and neurotensin in the basal ganglia or rats}
author = {Ceballos, M.L. de, Boyce, S, Taylor, M, Jenner, P, and Marsden, C D}
abstractNote = {Previous studies using radioimmunoassay procedures have failed to show age-related changes in the concentration of Met-and Leu-enkephalin or neurotensin in rat basal ganglia. In contrast, using a combined high-pressure liquid chromatography (HLPC)- radioimmunoassay (RIA) technique we now report considerable decreases in the levels of these neuropeptides in areas of basal ganglia of 22 months-old compared to 3 months-old male Wistar rats. The concentration of Met-enkephalin was greatly reduced in the striatum and nucleus accumbens, but not in substantia nigra, of old compared to young animals. There was a similarly large decrease in Leu-enkephalin content in striatum of old rats with less marked decreases occurring in both the nucleus accumbens and substantia nigra. Neurotensin levels in the striatum and substantia nigra were greatly reduced in old rats, with a less marked decrease in the nucleus accumbens.}
doi = {10.1016/0304-3940(87)90085-1}
journal = {Neurosci. Lett.; (Ireland)}
volume = {75:1}
journal type = {AC}
place = {Ireland}
year = {1987}
month = {Mar}
}