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Assessment of the role of chemotherapy and radiotherapy as adjuvant in the treatment of osteosarcomas of the limbs. A trial of the E. O. R. T. C. (Clinical Cooperative Group Radiotherapy/Chemotherapy) and of the S. I. O. P

Journal Article:

Abstract

Since the majority of patients with osteosarcomas of the limbs develop lung metastases, radiotherapy and/or chemotherapy are used as adjuvant therapy immediately after treatment of the primary. This article questions the roles of radiotherapy and chemotherapy in this instance. A brief review of previous non-randomized studies is made. The overall conclusion seemed to be that although adjuvant chemotherapy resulted in a higher survival of patients with osteosarcoma, in comparison with historical controls, this form of treatment has not proven to be superior to the benefit achieved by lung irradiation. In the light of these studies, the Clinical Cooperative Group Radiotherapy/Chemotherapy (E.O.R.T.C.) and the International Society for Pediatric Oncology (S.I.O.P.) have initiated a prospective, randomized trial comparing chemotherapy, radiotherapy of the lungs and a combination of both treatments. The details of these treatments are given. This trial will try to answer very fundamental questions on adjuvant therapy in osteosarcomas. Active participation of as many medical centres as possible is requested.
Authors:
van der Schueren, E; Breur, K; Cohen, P; [1]  Schweisguth, O; Voute, P A; Machin, D
  1. Wilhelmina Gasthuis, Department of Radiotherapy, Amsterdam, Netherlands
Publication Date:
Jul 01, 1979
Product Type:
Journal Article
Reference Number:
AIX-10-491375; EDB-80-051570
Resource Relation:
Journal Name: Eur. J. Cancer; (United Kingdom); Journal Volume: 15:7
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CHEMOTHERAPY; COMPARATIVE EVALUATIONS; OSTEOSARCOMAS; RADIOTHERAPY; CITROVORUM FACTOR; ENDOXAN; LIMBS; LUNGS; METASTASES; METHOTREXATE; ONCOVIN; RADIATION DOSES; ALKALOIDS; ALKYLATING AGENTS; ANTIMETABOLITES; ANTIMITOTIC DRUGS; BODY; BODY AREAS; DISEASES; DOSES; DRUGS; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANIC COMPOUNDS; ORGANS; RADIOLOGY; RESPIRATORY SYSTEM; SARCOMAS; SKELETAL DISEASES; THERAPY; 550603* - Medicine- External Radiation in Therapy- (1980-); 560151 - Radiation Effects on Animals- Man
OSTI ID:
5537580
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJCAA
Submitting Site:
INIS
Size:
Pages: 1001-1003
Announcement Date:
Feb 01, 1980

Journal Article:

Citation Formats

van der Schueren, E, Breur, K, Cohen, P, Schweisguth, O, Voute, P A, and Machin, D. Assessment of the role of chemotherapy and radiotherapy as adjuvant in the treatment of osteosarcomas of the limbs. A trial of the E. O. R. T. C. (Clinical Cooperative Group Radiotherapy/Chemotherapy) and of the S. I. O. P. United Kingdom: N. p., 1979. Web.
van der Schueren, E, Breur, K, Cohen, P, Schweisguth, O, Voute, P A, & Machin, D. Assessment of the role of chemotherapy and radiotherapy as adjuvant in the treatment of osteosarcomas of the limbs. A trial of the E. O. R. T. C. (Clinical Cooperative Group Radiotherapy/Chemotherapy) and of the S. I. O. P. United Kingdom.
van der Schueren, E, Breur, K, Cohen, P, Schweisguth, O, Voute, P A, and Machin, D. 1979. "Assessment of the role of chemotherapy and radiotherapy as adjuvant in the treatment of osteosarcomas of the limbs. A trial of the E. O. R. T. C. (Clinical Cooperative Group Radiotherapy/Chemotherapy) and of the S. I. O. P." United Kingdom.
@misc{etde_5537580,
title = {Assessment of the role of chemotherapy and radiotherapy as adjuvant in the treatment of osteosarcomas of the limbs. A trial of the E. O. R. T. C. (Clinical Cooperative Group Radiotherapy/Chemotherapy) and of the S. I. O. P}
author = {van der Schueren, E, Breur, K, Cohen, P, Schweisguth, O, Voute, P A, and Machin, D}
abstractNote = {Since the majority of patients with osteosarcomas of the limbs develop lung metastases, radiotherapy and/or chemotherapy are used as adjuvant therapy immediately after treatment of the primary. This article questions the roles of radiotherapy and chemotherapy in this instance. A brief review of previous non-randomized studies is made. The overall conclusion seemed to be that although adjuvant chemotherapy resulted in a higher survival of patients with osteosarcoma, in comparison with historical controls, this form of treatment has not proven to be superior to the benefit achieved by lung irradiation. In the light of these studies, the Clinical Cooperative Group Radiotherapy/Chemotherapy (E.O.R.T.C.) and the International Society for Pediatric Oncology (S.I.O.P.) have initiated a prospective, randomized trial comparing chemotherapy, radiotherapy of the lungs and a combination of both treatments. The details of these treatments are given. This trial will try to answer very fundamental questions on adjuvant therapy in osteosarcomas. Active participation of as many medical centres as possible is requested.}
journal = {Eur. J. Cancer; (United Kingdom)}
volume = {15:7}
journal type = {AC}
place = {United Kingdom}
year = {1979}
month = {Jul}
}