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Unique sensitivity of the rabbit eye to X-ray-induced ocular inflammation

Abstract

The effects of X-irradiation of the eye on ocular parameters known to be altered during the inflammatory process were studied on albino and pigmented rabbits, guinea pigs, owl monkeys, cats ducks and pigeons. Within 1.5-3.0 hr after exposure to 10 Gy (1000 rads), all irradiated eyes of either albino or pigmented rabbits showed a significant increase in intraocular pressure, iridial hyperemia, and development of flare and presence of cells in the anterior chamber. Four hours after exposure, the concentration of soluble proteins in the aqueous humor was increased, while that of ascorbic acid was decreased. In contrast, eyes of owl monkeys, cats guinea pigs, ducks and pigeons, exposed to the same or, in some cases, up to eight times higher doses of X-rays, showed no hypertension or development of other parameters of intraocular inflammation. These and previous findings suggest that rabbits, or possibly Lagomorphs in general, are unique among vertebrates in their sensitivity to the early intraocular inflammatory effects of X-rays. In addition, these results seriously question the use of this species as the primary, and frequently sole model for the study of ocular inflammation, its mediation and therapeutics.
Authors:
Bito, L Z; Klein, E M [1] 
  1. Columbia Univ., New York (USA). Coll. of Physicians and Surgeons
Publication Date:
Oct 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-671334; EDB-82-090816
Resource Relation:
Journal Name: Exp. Eye Res.; (United Kingdom); Journal Volume: 33:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; EYES; RADIATION INJURIES; RADIOSENSITIVITY; RABBITS; ASCORBIC ACID; CATS; COMPARATIVE EVALUATIONS; DOSE-RESPONSE RELATIONSHIPS; DUCKS; GUINEA PIGS; INFLAMMATION; MONKEYS; PIGEONS; PROTEINS; TIME DEPENDENCE; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BIRDS; BODY; BODY AREAS; ELECTROMAGNETIC RADIATION; FACE; FOWL; HEAD; INJURIES; IONIZING RADIATIONS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PRIMATES; RADIATION EFFECTS; RADIATIONS; RODENTS; SENSE ORGANS; SYMPTOMS; VERTEBRATES; VITAMINS; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5528654
Country of Origin:
United Kingdom
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EXERA
Submitting Site:
HEDB
Size:
Pages: 403-412
Announcement Date:
May 01, 1982

Citation Formats

Bito, L Z, and Klein, E M. Unique sensitivity of the rabbit eye to X-ray-induced ocular inflammation. United Kingdom: N. p., 1981. Web. doi:10.1016/S0014-4835(81)80092-9.
Bito, L Z, & Klein, E M. Unique sensitivity of the rabbit eye to X-ray-induced ocular inflammation. United Kingdom. https://doi.org/10.1016/S0014-4835(81)80092-9
Bito, L Z, and Klein, E M. 1981. "Unique sensitivity of the rabbit eye to X-ray-induced ocular inflammation." United Kingdom. https://doi.org/10.1016/S0014-4835(81)80092-9.
@misc{etde_5528654,
title = {Unique sensitivity of the rabbit eye to X-ray-induced ocular inflammation}
author = {Bito, L Z, and Klein, E M}
abstractNote = {The effects of X-irradiation of the eye on ocular parameters known to be altered during the inflammatory process were studied on albino and pigmented rabbits, guinea pigs, owl monkeys, cats ducks and pigeons. Within 1.5-3.0 hr after exposure to 10 Gy (1000 rads), all irradiated eyes of either albino or pigmented rabbits showed a significant increase in intraocular pressure, iridial hyperemia, and development of flare and presence of cells in the anterior chamber. Four hours after exposure, the concentration of soluble proteins in the aqueous humor was increased, while that of ascorbic acid was decreased. In contrast, eyes of owl monkeys, cats guinea pigs, ducks and pigeons, exposed to the same or, in some cases, up to eight times higher doses of X-rays, showed no hypertension or development of other parameters of intraocular inflammation. These and previous findings suggest that rabbits, or possibly Lagomorphs in general, are unique among vertebrates in their sensitivity to the early intraocular inflammatory effects of X-rays. In addition, these results seriously question the use of this species as the primary, and frequently sole model for the study of ocular inflammation, its mediation and therapeutics.}
doi = {10.1016/S0014-4835(81)80092-9}
journal = []
volume = {33:4}
journal type = {AC}
place = {United Kingdom}
year = {1981}
month = {Oct}
}