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Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation

Journal Article:

Abstract

Organ distribution of mercury after in utero mercury vapor exposure was investigated in neonatal guinea pigs. Mother guinea pigs in late gestation were exposed to 0.2-0.3 mg/m/sup 3/ mercury vapor 2 h per day until giving birth. Mercury concentrations in neonatal brain, lungs, heart, kidneys, plasma and erythrocytes were much lower than those of maternal organs and tissues. Neonatal liver, however, showed a mercury concentration twice as high as maternal liver. Mercury concentration ratios of erythrocytes to plasma in offspring were quite different from those of mothers, being 0.2-0.4 for offspring, and 1.3-3.0 for mothers. These results suggested that mercury vapor metabolism in fetuses was quite different from that in their mothers. This may be due to the different blood circulation, as mercury vapor transferred through the placental barrier would be rapidly oxidized into ionic mercury in fetal liver and accumulated in the organ. The different mercury vapor metabolism may prevent fetal brain, which is rapidly developing, and thus vulnerable, from being exposed to excessive mercury vapor.
Publication Date:
Apr 01, 1986
Product Type:
Journal Article
Reference Number:
EDB-86-139232
Resource Relation:
Journal Name: Arch. Toxikol.; (Germany, Federal Republic of); Journal Volume: 58:4
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; MERCURY; METABOLISM; PRENATAL EXPOSURE; TISSUE DISTRIBUTION; BLOOD PLASMA; BRAIN; ERYTHROCYTES; GUINEA PIGS; HEART; KIDNEYS; LUNGS; NEONATES; PREGNANCY; PROGENY; VAPORS; ANIMALS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DISTRIBUTION; ELEMENTS; FLUIDS; GASES; MAMMALS; MATERIALS; METALS; NERVOUS SYSTEM; ORGANS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5524047
Research Organizations:
Saint Marianna Univ., Kawasaki, Japan; Hokkaido Univ., Sapporo, Japan
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ATXKA
Submitting Site:
DE
Size:
Pages: 225-228
Announcement Date:

Journal Article:

Citation Formats

Yoshida, Minoru, Yamamura, Yukio, and Sataoh, Hiroshi. Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation. Germany: N. p., 1986. Web.
Yoshida, Minoru, Yamamura, Yukio, & Sataoh, Hiroshi. Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation. Germany.
Yoshida, Minoru, Yamamura, Yukio, and Sataoh, Hiroshi. 1986. "Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation." Germany.
@misc{etde_5524047,
title = {Distribution of mercury in guinea pig offspring after in utero exposure to mercury vapor during late gestation}
author = {Yoshida, Minoru, Yamamura, Yukio, and Sataoh, Hiroshi}
abstractNote = {Organ distribution of mercury after in utero mercury vapor exposure was investigated in neonatal guinea pigs. Mother guinea pigs in late gestation were exposed to 0.2-0.3 mg/m/sup 3/ mercury vapor 2 h per day until giving birth. Mercury concentrations in neonatal brain, lungs, heart, kidneys, plasma and erythrocytes were much lower than those of maternal organs and tissues. Neonatal liver, however, showed a mercury concentration twice as high as maternal liver. Mercury concentration ratios of erythrocytes to plasma in offspring were quite different from those of mothers, being 0.2-0.4 for offspring, and 1.3-3.0 for mothers. These results suggested that mercury vapor metabolism in fetuses was quite different from that in their mothers. This may be due to the different blood circulation, as mercury vapor transferred through the placental barrier would be rapidly oxidized into ionic mercury in fetal liver and accumulated in the organ. The different mercury vapor metabolism may prevent fetal brain, which is rapidly developing, and thus vulnerable, from being exposed to excessive mercury vapor.}
journal = {Arch. Toxikol.; (Germany, Federal Republic of)}
volume = {58:4}
journal type = {AC}
place = {Germany}
year = {1986}
month = {Apr}
}