Abstract
When confluent human skin cultures are ultraviolet (UV)-irradiated before infection with Herpes Simplex type 1 virus (HSV), their capacity to support virus growth is impaired. When the time interval between UV-exposure and infection is increased up to 36 hours, different recoveries of HSV production capacity are observed according to the origin of the host cells. 1) Two normal donors: the cells present a dose dependent recovery which is maximal for a dose (24 J/m/sup 2/) at which a plateau level of unscheduled DNA synthesis (UDS) is reached. 2) A mother of two Xeroderma Pigmentosum (XP) children: in this line which exhibits a normal level of UDS, the extent of recovery is significantly decreased after exposures <=12 J/m/sup 2/. 3) An XP child: these cells have a normal level of UDS (XP variant) whereas they present a low extent of recovery as compared with that of the normal subjects. 4) Five XP children: in these excision deficient lines (UDS < 15%), HSV production capacity decreases with increasing time intervals after UV exposure for doses >=3 J/m/sup 2/. For doses < 3 J/m/sup 2/, a small recovery with an overshoot of viral production is observed 24 h after UV exposure in the
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Coppey, J;
Nocentini, S;
[1]
Moreno, G
[2]
- Institut du Radium, 75 - Paris (France)
- Institut National de la Sante et de la Recherche Medicale (INSERM), Hopital de Bicetre, 94 - le Kremlin-Bicetre (France)
Citation Formats
Coppey, J, Nocentini, S, and Moreno, G.
Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin.
France: N. p.,
1978.
Web.
Coppey, J, Nocentini, S, & Moreno, G.
Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin.
France.
Coppey, J, Nocentini, S, and Moreno, G.
1978.
"Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin."
France.
@misc{etde_5519181,
title = {Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin}
author = {Coppey, J, Nocentini, S, and Moreno, G}
abstractNote = {When confluent human skin cultures are ultraviolet (UV)-irradiated before infection with Herpes Simplex type 1 virus (HSV), their capacity to support virus growth is impaired. When the time interval between UV-exposure and infection is increased up to 36 hours, different recoveries of HSV production capacity are observed according to the origin of the host cells. 1) Two normal donors: the cells present a dose dependent recovery which is maximal for a dose (24 J/m/sup 2/) at which a plateau level of unscheduled DNA synthesis (UDS) is reached. 2) A mother of two Xeroderma Pigmentosum (XP) children: in this line which exhibits a normal level of UDS, the extent of recovery is significantly decreased after exposures <=12 J/m/sup 2/. 3) An XP child: these cells have a normal level of UDS (XP variant) whereas they present a low extent of recovery as compared with that of the normal subjects. 4) Five XP children: in these excision deficient lines (UDS < 15%), HSV production capacity decreases with increasing time intervals after UV exposure for doses >=3 J/m/sup 2/. For doses < 3 J/m/sup 2/, a small recovery with an overshoot of viral production is observed 24 h after UV exposure in the lines (three) which present the highest UDS (10-15%) and not in the two lines which present a very low UDS (1-2%).}
journal = []
volume = {65:3}
place = {France}
year = {1978}
month = {Jan}
}
title = {Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin}
author = {Coppey, J, Nocentini, S, and Moreno, G}
abstractNote = {When confluent human skin cultures are ultraviolet (UV)-irradiated before infection with Herpes Simplex type 1 virus (HSV), their capacity to support virus growth is impaired. When the time interval between UV-exposure and infection is increased up to 36 hours, different recoveries of HSV production capacity are observed according to the origin of the host cells. 1) Two normal donors: the cells present a dose dependent recovery which is maximal for a dose (24 J/m/sup 2/) at which a plateau level of unscheduled DNA synthesis (UDS) is reached. 2) A mother of two Xeroderma Pigmentosum (XP) children: in this line which exhibits a normal level of UDS, the extent of recovery is significantly decreased after exposures <=12 J/m/sup 2/. 3) An XP child: these cells have a normal level of UDS (XP variant) whereas they present a low extent of recovery as compared with that of the normal subjects. 4) Five XP children: in these excision deficient lines (UDS < 15%), HSV production capacity decreases with increasing time intervals after UV exposure for doses >=3 J/m/sup 2/. For doses < 3 J/m/sup 2/, a small recovery with an overshoot of viral production is observed 24 h after UV exposure in the lines (three) which present the highest UDS (10-15%) and not in the two lines which present a very low UDS (1-2%).}
journal = []
volume = {65:3}
place = {France}
year = {1978}
month = {Jan}
}