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Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin

Abstract

When confluent human skin cultures are ultraviolet (UV)-irradiated before infection with Herpes Simplex type 1 virus (HSV), their capacity to support virus growth is impaired. When the time interval between UV-exposure and infection is increased up to 36 hours, different recoveries of HSV production capacity are observed according to the origin of the host cells. 1) Two normal donors: the cells present a dose dependent recovery which is maximal for a dose (24 J/m/sup 2/) at which a plateau level of unscheduled DNA synthesis (UDS) is reached. 2) A mother of two Xeroderma Pigmentosum (XP) children: in this line which exhibits a normal level of UDS, the extent of recovery is significantly decreased after exposures <=12 J/m/sup 2/. 3) An XP child: these cells have a normal level of UDS (XP variant) whereas they present a low extent of recovery as compared with that of the normal subjects. 4) Five XP children: in these excision deficient lines (UDS < 15%), HSV production capacity decreases with increasing time intervals after UV exposure for doses >=3 J/m/sup 2/. For doses < 3 J/m/sup 2/, a small recovery with an overshoot of viral production is observed 24 h after UV exposure in the  More>>
Authors:
Coppey, J; Nocentini, S; [1]  Moreno, G [2] 
  1. Institut du Radium, 75 - Paris (France)
  2. Institut National de la Sante et de la Recherche Medicale (INSERM), Hopital de Bicetre, 94 - le Kremlin-Bicetre (France)
Publication Date:
Jan 01, 1978
Product Type:
Conference
Reference Number:
AIX-11-499542; EDB-80-057780
Resource Relation:
Journal Name: Bull. Cancer; (France); Journal Volume: 65:3; Conference: Symposium on skin carcinogenesis, Paris, France, 13 - 14 Jan 1978
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; HERPES SIMPLEX; INFECTIVITY; XP CELLS; BIOLOGICAL REPAIR; BIOLOGICAL INDICATORS; DNA; FIBROBLASTS; GROWTH; SKIN; TIME DEPENDENCE; ULTRAVIOLET RADIATION; ANIMAL CELLS; BIOLOGICAL RECOVERY; BODY; CONNECTIVE TISSUE CELLS; DISEASES; ELECTROMAGNETIC RADIATION; INFECTIOUS DISEASES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; ORGANS; RADIATIONS; RECOVERY; REPAIR; SKIN DISEASES; SOMATIC CELLS; 560121* - Radiation Effects on Cells- External Source- (-1987); 560131 - Radiation Effects on Microorganisms- Basic Studies- (-1987)
OSTI ID:
5519181
Country of Origin:
France
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: BUCAB
Submitting Site:
INIS
Size:
Pages: 335-340
Announcement Date:

Citation Formats

Coppey, J, Nocentini, S, and Moreno, G. Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin. France: N. p., 1978. Web.
Coppey, J, Nocentini, S, & Moreno, G. Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin. France.
Coppey, J, Nocentini, S, and Moreno, G. 1978. "Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin." France.
@misc{etde_5519181,
title = {Herpes virus production as a marker of repair in ultraviolet irradiated human skin cells of different origin}
author = {Coppey, J, Nocentini, S, and Moreno, G}
abstractNote = {When confluent human skin cultures are ultraviolet (UV)-irradiated before infection with Herpes Simplex type 1 virus (HSV), their capacity to support virus growth is impaired. When the time interval between UV-exposure and infection is increased up to 36 hours, different recoveries of HSV production capacity are observed according to the origin of the host cells. 1) Two normal donors: the cells present a dose dependent recovery which is maximal for a dose (24 J/m/sup 2/) at which a plateau level of unscheduled DNA synthesis (UDS) is reached. 2) A mother of two Xeroderma Pigmentosum (XP) children: in this line which exhibits a normal level of UDS, the extent of recovery is significantly decreased after exposures <=12 J/m/sup 2/. 3) An XP child: these cells have a normal level of UDS (XP variant) whereas they present a low extent of recovery as compared with that of the normal subjects. 4) Five XP children: in these excision deficient lines (UDS < 15%), HSV production capacity decreases with increasing time intervals after UV exposure for doses >=3 J/m/sup 2/. For doses < 3 J/m/sup 2/, a small recovery with an overshoot of viral production is observed 24 h after UV exposure in the lines (three) which present the highest UDS (10-15%) and not in the two lines which present a very low UDS (1-2%).}
journal = {Bull. Cancer; (France)}
volume = {65:3}
place = {France}
year = {1978}
month = {Jan}
}