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Studies on brain blood-flow with N-isopropyl-(I-123)p-iodoamphetamine in dementia

Journal Article:

Abstract

A differentiation between patients with senile dementia of Alzheimer type (SDAT) and patients with multi-infarct dementia (MID) was attempted in this paper. Twenty normal subjects, 20 SDAT and 20 MID patients were studied with single photon emission computed tomography (SPECT) using N-isopropyl-(I-123)p-iodoamphetamine ({sup 123}I-IMP). SPECT was started 10 minutes after the injection of 3.0 mCi {sup 123}I-IMP. Eight anatomical regions (region of interest, ROI) were examined at the level of the basal ganglia and ten at the level of the centrum semiovale. The count ratio of each ROI to the average was calculated and tested with Student's t-test of mean differences. The ratios of right inferior frontal region and superior frontal region were significantly lower in the SDAT patients than in the normal subjects. The left superior frontal region showed lower mean ratios in SDAT patients, but the difference was not statistically significant. This study supports the suggestion that there is frontal region hypofunction in SDAT patients. SPECT with {sup 123}I-IMP is a useful method in the non-invasive assessment of cerebral pathophysiology in dementia. (author).
Authors:
Shin, Akinori [1] 
  1. Osaka Medical Coll., Takatsuki (Japan)
Publication Date:
Jun 01, 1989
Product Type:
Journal Article
Reference Number:
JPN-89-013371; EDB-89-162358
Resource Relation:
Journal Name: Osaka Ika Daigaku Zasshi; (Japan); Journal Volume: 48:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BRAIN; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; IODINE 123; BENZEDRINE; BLOOD FLOW; CAT SCANNING; ELDERLY PEOPLE; MENTAL DISORDERS; PATIENTS; REFERENCE MAN; AGE GROUPS; AGED ADULTS; AMINES; AUTONOMIC NERVOUS SYSTEM AGENTS; BETA DECAY RADIOISOTOPES; BODY; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EMISSION COMPUTED TOMOGRAPHY; HOURS LIVING RADIOISOTOPES; HUMAN POPULATIONS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; MINORITY GROUPS; NERVOUS SYSTEM; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; POPULATIONS; RADIOISOTOPES; SYMPATHOMIMETICS; TOMOGRAPHY; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5515865
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0030-6118; CODEN: OIDZA
Submitting Site:
JPN
Size:
Pages: 41-54
Announcement Date:
Oct 01, 1989

Journal Article:

Citation Formats

Shin, Akinori. Studies on brain blood-flow with N-isopropyl-(I-123)p-iodoamphetamine in dementia. Japan: N. p., 1989. Web.
Shin, Akinori. Studies on brain blood-flow with N-isopropyl-(I-123)p-iodoamphetamine in dementia. Japan.
Shin, Akinori. 1989. "Studies on brain blood-flow with N-isopropyl-(I-123)p-iodoamphetamine in dementia." Japan.
@misc{etde_5515865,
title = {Studies on brain blood-flow with N-isopropyl-(I-123)p-iodoamphetamine in dementia}
author = {Shin, Akinori}
abstractNote = {A differentiation between patients with senile dementia of Alzheimer type (SDAT) and patients with multi-infarct dementia (MID) was attempted in this paper. Twenty normal subjects, 20 SDAT and 20 MID patients were studied with single photon emission computed tomography (SPECT) using N-isopropyl-(I-123)p-iodoamphetamine ({sup 123}I-IMP). SPECT was started 10 minutes after the injection of 3.0 mCi {sup 123}I-IMP. Eight anatomical regions (region of interest, ROI) were examined at the level of the basal ganglia and ten at the level of the centrum semiovale. The count ratio of each ROI to the average was calculated and tested with Student's t-test of mean differences. The ratios of right inferior frontal region and superior frontal region were significantly lower in the SDAT patients than in the normal subjects. The left superior frontal region showed lower mean ratios in SDAT patients, but the difference was not statistically significant. This study supports the suggestion that there is frontal region hypofunction in SDAT patients. SPECT with {sup 123}I-IMP is a useful method in the non-invasive assessment of cerebral pathophysiology in dementia. (author).}
journal = {Osaka Ika Daigaku Zasshi; (Japan)}
volume = {48:1}
journal type = {AC}
place = {Japan}
year = {1989}
month = {Jun}
}