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Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia. A study with SPECT using sup 133 Xe inhalation method

Journal Article:

Abstract

Twenty-one patients with senile dementia of Alzheimer type (SDAT), 11 patients with multi-infarct dementia (MID), and 6 healthy volunteers were examined by SPECT using Xe-inhalation method. These patients also underwent an intelligence test according to the Gottfries-Brane-Steen (GBS) scale. Patients with mild SDAT did not have a significantly decreased regional cerebral blood flow (rCBF). In moderate or severe cases, however, a significantly decreased rCBF was bilaterally observed in all regions, except for the basal ganglia. This was marked in the temporoparietal region. A group of moderate or severe MID patients had a significantly decreased rCBF especially in the basal ganglia. It was also observed in the temporoparietal region, but not in the frontal region. Among the SDAT patients, there was a good correlation between rCBF and GBS scale in all the regions, except for the basal ganglia. In the case of MID patients, correlations were observed both between rCBF in the left side of the brain and clinical findings according to the method of Hasegawa and between rCBF in the right side of the frontal region and the motor function on the GBS scale. These findings may have implications for the different pathophysiology between SDAT and MID. (N.K.).
Publication Date:
Sep 01, 1989
Product Type:
Journal Article
Reference Number:
JPN-89-013387; EDB-89-162361
Resource Relation:
Journal Name: Rinsho Seishin Igaku (Japanese Journal of Clinical Psychiatry); (Japan); Journal Volume: 18:9
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CEREBRUM; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; XENON 133; BLOOD FLOW; ELDERLY PEOPLE; INHALATION; MENTAL DISORDERS; PATIENTS; AGE GROUPS; AGED ADULTS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; BRAIN; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; HUMAN POPULATIONS; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MINORITY GROUPS; NERVOUS SYSTEM; NUCLEI; ORGANS; POPULATIONS; RADIOISOTOPES; TOMOGRAPHY; XENON ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5515849
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0300-032X; CODEN: RSIGE
Submitting Site:
JPN
Size:
Pages: 1387-1394
Announcement Date:

Journal Article:

Citation Formats

Shinohara, Masao, Kawakatsu, Shinobu, Morinobu, Shigeru, Oiji, Arata, Sagawa, Katsuo, Yazaki, Mitsuyasu, Totsuka, Shirou, Komatani, Akio, and Yamaguchi, Koichi. Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia. A study with SPECT using sup 133 Xe inhalation method. Japan: N. p., 1989. Web.
Shinohara, Masao, Kawakatsu, Shinobu, Morinobu, Shigeru, Oiji, Arata, Sagawa, Katsuo, Yazaki, Mitsuyasu, Totsuka, Shirou, Komatani, Akio, & Yamaguchi, Koichi. Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia. A study with SPECT using sup 133 Xe inhalation method. Japan.
Shinohara, Masao, Kawakatsu, Shinobu, Morinobu, Shigeru, Oiji, Arata, Sagawa, Katsuo, Yazaki, Mitsuyasu, Totsuka, Shirou, Komatani, Akio, and Yamaguchi, Koichi. 1989. "Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia. A study with SPECT using sup 133 Xe inhalation method." Japan.
@misc{etde_5515849,
title = {Regional cerebral blood flow and its correlation with clinical assessment in senile dementia of Alzheimer type and multi-infarct dementia. A study with SPECT using sup 133 Xe inhalation method}
author = {Shinohara, Masao, Kawakatsu, Shinobu, Morinobu, Shigeru, Oiji, Arata, Sagawa, Katsuo, Yazaki, Mitsuyasu, Totsuka, Shirou, Komatani, Akio, and Yamaguchi, Koichi}
abstractNote = {Twenty-one patients with senile dementia of Alzheimer type (SDAT), 11 patients with multi-infarct dementia (MID), and 6 healthy volunteers were examined by SPECT using Xe-inhalation method. These patients also underwent an intelligence test according to the Gottfries-Brane-Steen (GBS) scale. Patients with mild SDAT did not have a significantly decreased regional cerebral blood flow (rCBF). In moderate or severe cases, however, a significantly decreased rCBF was bilaterally observed in all regions, except for the basal ganglia. This was marked in the temporoparietal region. A group of moderate or severe MID patients had a significantly decreased rCBF especially in the basal ganglia. It was also observed in the temporoparietal region, but not in the frontal region. Among the SDAT patients, there was a good correlation between rCBF and GBS scale in all the regions, except for the basal ganglia. In the case of MID patients, correlations were observed both between rCBF in the left side of the brain and clinical findings according to the method of Hasegawa and between rCBF in the right side of the frontal region and the motor function on the GBS scale. These findings may have implications for the different pathophysiology between SDAT and MID. (N.K.).}
journal = {Rinsho Seishin Igaku (Japanese Journal of Clinical Psychiatry); (Japan)}
volume = {18:9}
journal type = {AC}
place = {Japan}
year = {1989}
month = {Sep}
}