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Measurement of cerebral blood flow by single photon emission computed tomography in cases of internal carotid artery occlusion

Journal Article:

Abstract

Cerebral blood flow (CBF) was measured with {sup 133}xenon inhalation and single photon emission computed tomography in 33 cases of internal carotid artery occlusion, in the resting state and 25 minutes after acetazolamide administration. The patient population consisted of 24 males and nine females with a mean age of 57 years, who presented with transient ischemic attacks or stroke. Acetazolamide inhibits carbonic anhydrase, and CBF increases as a result of dilatation of cerebral arteries due to CO{sub 2} accumulation. The mean CBF was 46 ml/100 g/min on the affected hemisphere and 56 ml/100 g/min on the unaffected hemisphere. The mean CBF value obtained by the same method in 10 normal volunteers was 55 ml/100 g/min. The average increase in CBF after acetazolamide administration was 9% on the affected side and 17% on the unaffected side. The average increase in 10 normal volunteers was 32%. The reduced cerebral arterial reactivity to acetazolamide administration was bilateral in the patient group, suggesting that the cerebral arteries were dilated so as to maintain normal CBF. Extra-intracranial (EC-IC) bypass surgery was performed in nine patients. Preoperatively, the mean CBF was 48 ml/100 g/min on the affected side and 57 ml/100 g/min on the unaffected side.  More>>
Authors:
Sunada, Ichiro [1] 
  1. Osaka City Univ. (Japan). Faculty of Medicine
Publication Date:
Jun 01, 1989
Product Type:
Journal Article
Reference Number:
JPN-89-013341; EDB-89-162365
Resource Relation:
Journal Name: Neurologia Medico-Chirurgica; (Japan); Journal Volume: 29:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; CAROTID ARTERIES; CEREBRAL ARTERIES; SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY; CEREBRUM; BLOOD FLOW; DIURETICS; IMAGES; INHALATION; ISCHEMIA; PATIENTS; VASCULAR DISEASES; XENON 133; ARTERIES; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BLOOD VESSELS; BODY; BRAIN; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COMPUTERIZED TOMOGRAPHY; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DRUGS; EMISSION COMPUTED TOMOGRAPHY; EVEN-ODD NUCLEI; INTAKE; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; NERVOUS SYSTEM; NUCLEI; ORGANS; RADIOISOTOPES; TOMOGRAPHY; XENON ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5515791
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: ISSN 0387-2572; CODEN: NMCHB
Submitting Site:
JPN
Size:
Pages: 496-502
Announcement Date:
Oct 01, 1989

Journal Article:

Citation Formats

Sunada, Ichiro. Measurement of cerebral blood flow by single photon emission computed tomography in cases of internal carotid artery occlusion. Japan: N. p., 1989. Web.
Sunada, Ichiro. Measurement of cerebral blood flow by single photon emission computed tomography in cases of internal carotid artery occlusion. Japan.
Sunada, Ichiro. 1989. "Measurement of cerebral blood flow by single photon emission computed tomography in cases of internal carotid artery occlusion." Japan.
@misc{etde_5515791,
title = {Measurement of cerebral blood flow by single photon emission computed tomography in cases of internal carotid artery occlusion}
author = {Sunada, Ichiro}
abstractNote = {Cerebral blood flow (CBF) was measured with {sup 133}xenon inhalation and single photon emission computed tomography in 33 cases of internal carotid artery occlusion, in the resting state and 25 minutes after acetazolamide administration. The patient population consisted of 24 males and nine females with a mean age of 57 years, who presented with transient ischemic attacks or stroke. Acetazolamide inhibits carbonic anhydrase, and CBF increases as a result of dilatation of cerebral arteries due to CO{sub 2} accumulation. The mean CBF was 46 ml/100 g/min on the affected hemisphere and 56 ml/100 g/min on the unaffected hemisphere. The mean CBF value obtained by the same method in 10 normal volunteers was 55 ml/100 g/min. The average increase in CBF after acetazolamide administration was 9% on the affected side and 17% on the unaffected side. The average increase in 10 normal volunteers was 32%. The reduced cerebral arterial reactivity to acetazolamide administration was bilateral in the patient group, suggesting that the cerebral arteries were dilated so as to maintain normal CBF. Extra-intracranial (EC-IC) bypass surgery was performed in nine patients. Preoperatively, the mean CBF was 48 ml/100 g/min on the affected side and 57 ml/100 g/min on the unaffected side. With postoperative acetazolamide administration, the percent increase in CBF rose from 13% to 22% on the affected side and from 17% to 23% on the unaffected side. The bilateral change toward normal in cerebral arterial reactivity to acetazolamide indicates that the dilated cerebral arteries returned to normal after EC-IC bypass surgery. This suggests that bypass surgery is effective in patients with internal carotid artery occlusion in whom ischemia is caused only by hemodynamic factors, and that measurement of CBF via acetazolamide loading is useful in identifying appropriate candidates for bypass surgery.}
journal = {Neurologia Medico-Chirurgica; (Japan)}
volume = {29:6}
journal type = {AC}
place = {Japan}
year = {1989}
month = {Jun}
}