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Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals

Journal Article:

Abstract

The blood-brain barrier to intravascular Evans blue-albumin was opened in monkeys and rabbits by infusing isotonic saline for 15 s into the common carotid artery, when the external carotid was clamped temporarily and the lingual was catheterized for measuring pressure. Barrier opening correlated better with infusion pressure than with infusion rate, and occurred at carotid artery pressures above 170 mmHg. Systematic hypertension induced by Aramine increased barrier vulnerability by causing a higher net carotid artery pressure to be attained at a given infusion rate.
Authors:
Rapoport, S I [1] 
  1. Baltimore City Hospitals, MD (USA)
Publication Date:
Jan 01, 1978
Product Type:
Journal Article
Reference Number:
AIX-10-491286; EDB-80-042120
Resource Relation:
Journal Name: Acta Radiol., Diagn.; (Sweden); Journal Volume: 19:6
Subject:
59 BASIC BIOLOGICAL SCIENCES; BLOOD-BRAIN BARRIER; RESPONSE MODIFYING FACTORS; CONTRAST MEDIA; ALBUMINS; BIOMEDICAL RADIOGRAPHY; BRAIN; CAROTID ARTERIES; EDEMA; EVANS BLUE; HYPERTENSION; INFUSION; INTRAVENOUS INJECTION; MONKEYS; OSMOSIS; RABBITS; SALINITY; ANIMALS; ARTERIES; AZO COMPOUNDS; AZO DYES; BLOOD VESSELS; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; DIAGNOSTIC TECHNIQUES; DISEASES; DYES; INJECTION; INTAKE; MAMMALS; MEDICINE; NERVOUS SYSTEM; NUCLEAR MEDICINE; ORGANIC ACIDS; ORGANIC COMPOUNDS; ORGANIC NITROGEN COMPOUNDS; ORGANIC SULFUR COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; PRIMATES; PROTEINS; RADIOLOGY; REAGENTS; SULFONIC ACIDS; SYMPTOMS; VASCULAR DISEASES; VERTEBRATES; 551001* - Physiological Systems- Tracer Techniques
OSTI ID:
5504182
Country of Origin:
Sweden
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: ACRDA
Submitting Site:
INIS
Size:
Pages: 921-932
Announcement Date:

Journal Article:

Citation Formats

Rapoport, S I. Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals. Sweden: N. p., 1978. Web.
Rapoport, S I. Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals. Sweden.
Rapoport, S I. 1978. "Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals." Sweden.
@misc{etde_5504182,
title = {Blood-brain barrier opening by isotonic saline infusion in normotensive and hypertensive animals}
author = {Rapoport, S I}
abstractNote = {The blood-brain barrier to intravascular Evans blue-albumin was opened in monkeys and rabbits by infusing isotonic saline for 15 s into the common carotid artery, when the external carotid was clamped temporarily and the lingual was catheterized for measuring pressure. Barrier opening correlated better with infusion pressure than with infusion rate, and occurred at carotid artery pressures above 170 mmHg. Systematic hypertension induced by Aramine increased barrier vulnerability by causing a higher net carotid artery pressure to be attained at a given infusion rate.}
journal = {Acta Radiol., Diagn.; (Sweden)}
volume = {19:6}
journal type = {AC}
place = {Sweden}
year = {1978}
month = {Jan}
}