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Autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia found in an atomic bomb survivor

Journal Article:

Abstract

An autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia, presumably on a sequela to the atomic bomb in Hiroshima is reported. On admission, severe anemia and thrombocytosis were found and the bone marrow aspiration showed myeloid hyperplasia without definite maturation arrest. Mild to moderate eosinophilia and basophilia continued during the course of the disease, accompaning mild monocytosis 2 years later. Furthermore, he had the radical operation for the early gastric cancer in this preleukemic stage. After the administration of methenolone acetate (25 mg/day), severe anemia has dramatically improved, but leukocytosis with profound monocytosis persisted, and subsequently acute myelocytic leukemia developed. He died from an intracerebral bleeding due to an accidental trauma on the head. Autopsy findings disclosed the systemic leukemic infiltration. Repeated chromosome analyses revealed the mosaic karyotype of 46, XY/45, XY, -16 on admission, but it was 46, XY/46, XY, del (8) (p 12) in the overt leukemic phase. The granulopoietic colony forming capacity of bone marrow cells was already low one year before the onset of overt leukemia. This finding suggested that the existence of an abnormal clone could be predictable. In addition, the possible causative effect of the exposure to the atomic bomb in leukemogenesis  More>>
Authors:
Sonoda, Y; Edagawa, J; Taniwaki, M; Ide, T; Misawa, S [1] 
  1. Kyoto Prefectural Univ. of Medicine (Japan)
Publication Date:
Mar 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-661613; EDB-82-079817
Resource Relation:
Journal Name: Rinsho Ketsueki; (Japan); Journal Volume: 22:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 45 MILITARY TECHNOLOGY, WEAPONRY, AND NATIONAL DEFENSE; A-BOMB SURVIVORS; DELAYED RADIATION EFFECTS; MYELOID LEUKEMIA; NUCLEAR WEAPONS; LEUKEMOGENESIS; ANEMIAS; AUTOPSY; BASOPHILS; BONE MARROW CELLS; EOSINOPHILS; KARYOTYPE; LYMPHOCYTES; MONOCYTES; NUCLEAR EXPLOSIONS; ANIMAL CELLS; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY FLUIDS; CARCINOGENESIS; CONNECTIVE TISSUE CELLS; DIAGNOSTIC TECHNIQUES; DISEASES; EXPLOSIONS; HEMIC DISEASES; HUMAN POPULATIONS; LEUKEMIA; LEUKOCYTES; MATERIALS; NEOPLASMS; PATHOGENESIS; POPULATIONS; RADIATION EFFECTS; SOMATIC CELLS; SYMPTOMS; WEAPONS; 560151* - Radiation Effects on Animals- Man; 450202 - Explosions & Explosives- Nuclear- Weaponry- (-1989)
OSTI ID:
5502641
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: RIKEB
Submitting Site:
INIS
Size:
Pages: 357-363
Announcement Date:

Journal Article:

Citation Formats

Sonoda, Y, Edagawa, J, Taniwaki, M, Ide, T, and Misawa, S. Autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia found in an atomic bomb survivor. Japan: N. p., 1981. Web.
Sonoda, Y, Edagawa, J, Taniwaki, M, Ide, T, & Misawa, S. Autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia found in an atomic bomb survivor. Japan.
Sonoda, Y, Edagawa, J, Taniwaki, M, Ide, T, and Misawa, S. 1981. "Autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia found in an atomic bomb survivor." Japan.
@misc{etde_5502641,
title = {Autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia found in an atomic bomb survivor}
author = {Sonoda, Y, Edagawa, J, Taniwaki, M, Ide, T, and Misawa, S}
abstractNote = {An autopsy case of acute myelocytic leukemia preceded by hemopoietic dysplasia, presumably on a sequela to the atomic bomb in Hiroshima is reported. On admission, severe anemia and thrombocytosis were found and the bone marrow aspiration showed myeloid hyperplasia without definite maturation arrest. Mild to moderate eosinophilia and basophilia continued during the course of the disease, accompaning mild monocytosis 2 years later. Furthermore, he had the radical operation for the early gastric cancer in this preleukemic stage. After the administration of methenolone acetate (25 mg/day), severe anemia has dramatically improved, but leukocytosis with profound monocytosis persisted, and subsequently acute myelocytic leukemia developed. He died from an intracerebral bleeding due to an accidental trauma on the head. Autopsy findings disclosed the systemic leukemic infiltration. Repeated chromosome analyses revealed the mosaic karyotype of 46, XY/45, XY, -16 on admission, but it was 46, XY/46, XY, del (8) (p 12) in the overt leukemic phase. The granulopoietic colony forming capacity of bone marrow cells was already low one year before the onset of overt leukemia. This finding suggested that the existence of an abnormal clone could be predictable. In addition, the possible causative effect of the exposure to the atomic bomb in leukemogenesis in this case is discussed.}
journal = {Rinsho Ketsueki; (Japan)}
volume = {22:3}
journal type = {AC}
place = {Japan}
year = {1981}
month = {Mar}
}