You need JavaScript to view this

Brain atrophy during aging. Quantitative studies with X-CT and NMR-CT

Journal Article:

Abstract

Age-related brain atrophy was investigated in thousands of persons with no neurologic disturbances using X-CT and NMR-CT. Brain atrophy was minimal in 34-35 years old in both sexes, increased exponentially to the increasing age after 34-35 years, and probably resulted in dementia, such as vascular or multi-infarct dementia. Brain atrophy was significantly greater in men than in women at all ages. Brain volumes were maximal in 34-35 years old in both sexes with minimal individual differences which increased proportionally to the increasing age. Remarkable individual differences in the extent of brain atrophy (20 - 30 %) existed among aged subjects. Progression of brain atrophy was closely related to loss of mental activities independently of their ages. Our longitudinal study has revealed that the most important factors promoting brain atrophy during aging was the decrease in the cerebral blood flow. We have classified brain atrophy into sulcal and cisternal enlargement type (type I), ventricular enlargement type (type II) and mixed type (type III) according to the clinical study using NMR-CT. Brain atrophy of type I progresses significantly in almost all of the geriatric disorders. This type of brain atrophy progresses significantly in heavy smokers and drinkers. Therefore this type of brain  More>>
Publication Date:
Dec 01, 1985
Product Type:
Journal Article
Reference Number:
AIX-17-054888; EDB-86-146137
Resource Relation:
Journal Name: Nichidoku Iho.; (Japan); Journal Volume: 30:3-4
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; 59 BASIC BIOLOGICAL SCIENCES; BRAIN; ATROPHY; BLOOD FLOW; CAT SCANNING; NUCLEAR MAGNETIC RESONANCE; CEREBRAL ARTERIES; ETHANOL; BIOLOGICAL EFFECTS; TOBACCO SMOKES; AGE DEPENDENCE; CEREBROSPINAL FLUID; IMAGES; PATIENTS; SEX DEPENDENCE; VASCULAR DISEASES; VOLUME; AEROSOLS; ALCOHOLS; ARTERIES; BIOLOGICAL MATERIALS; BLOOD VESSELS; BODY; BODY FLUIDS; CARDIOVASCULAR SYSTEM; CENTRAL NERVOUS SYSTEM; COLLOIDS; COMPUTERIZED TOMOGRAPHY; DIAGNOSTIC TECHNIQUES; DISEASES; DISPERSIONS; HYDROXY COMPOUNDS; MAGNETIC RESONANCE; MATERIALS; NERVOUS SYSTEM; ORGANIC COMPOUNDS; ORGANS; PATHOLOGICAL CHANGES; RESIDUES; RESONANCE; SMOKES; SOLS; TOMOGRAPHY; 550602* - Medicine- External Radiation in Diagnostics- (1980-); 550900 - Pathology
OSTI ID:
5496295
Research Organizations:
Tohoku Univ., Sendai, Japan. Research Inst. for Tuberculosis and Cancer
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: NIIHA
Submitting Site:
INIS
Size:
Pages: 614-632
Announcement Date:

Journal Article:

Citation Formats

Matsuzawa, Taiju, Yamada, Kenji, Yamada, Susumu, Ono, Shuichi, Takeda, Shunpei, Hatazawa, Jun, Ito, Masatoshi, and Kubota, Kazuo. Brain atrophy during aging. Quantitative studies with X-CT and NMR-CT. Japan: N. p., 1985. Web.
Matsuzawa, Taiju, Yamada, Kenji, Yamada, Susumu, Ono, Shuichi, Takeda, Shunpei, Hatazawa, Jun, Ito, Masatoshi, & Kubota, Kazuo. Brain atrophy during aging. Quantitative studies with X-CT and NMR-CT. Japan.
Matsuzawa, Taiju, Yamada, Kenji, Yamada, Susumu, Ono, Shuichi, Takeda, Shunpei, Hatazawa, Jun, Ito, Masatoshi, and Kubota, Kazuo. 1985. "Brain atrophy during aging. Quantitative studies with X-CT and NMR-CT." Japan.
@misc{etde_5496295,
title = {Brain atrophy during aging. Quantitative studies with X-CT and NMR-CT}
author = {Matsuzawa, Taiju, Yamada, Kenji, Yamada, Susumu, Ono, Shuichi, Takeda, Shunpei, Hatazawa, Jun, Ito, Masatoshi, and Kubota, Kazuo}
abstractNote = {Age-related brain atrophy was investigated in thousands of persons with no neurologic disturbances using X-CT and NMR-CT. Brain atrophy was minimal in 34-35 years old in both sexes, increased exponentially to the increasing age after 34-35 years, and probably resulted in dementia, such as vascular or multi-infarct dementia. Brain atrophy was significantly greater in men than in women at all ages. Brain volumes were maximal in 34-35 years old in both sexes with minimal individual differences which increased proportionally to the increasing age. Remarkable individual differences in the extent of brain atrophy (20 - 30 %) existed among aged subjects. Progression of brain atrophy was closely related to loss of mental activities independently of their ages. Our longitudinal study has revealed that the most important factors promoting brain atrophy during aging was the decrease in the cerebral blood flow. We have classified brain atrophy into sulcal and cisternal enlargement type (type I), ventricular enlargement type (type II) and mixed type (type III) according to the clinical study using NMR-CT. Brain atrophy of type I progresses significantly in almost all of the geriatric disorders. This type of brain atrophy progresses significantly in heavy smokers and drinkers. Therefore this type of brain atrophy might be caused by the decline in the blood flow in anterior and middle cerebral arteries. Brain atrophy of type II was caused by the disturbance of cerebrospinal fluid circulation after cerebral bleeding and subarachnoid bleeding. Brain atrophy of type III was seen in vascular dementia or multi-infarct dementia which was caused by loss of brain matter after multiple infarction, and was seen also in dementia of Alzheimer type in which degeneration of nerve cells results in brain atrophy. NMR-CT can easily detect small infarction (lacunae) and edematous lesions resulting from ischemia and hypertensive encephalopathy. (J.P.N.).}
journal = {Nichidoku Iho.; (Japan)}
volume = {30:3-4}
journal type = {AC}
place = {Japan}
year = {1985}
month = {Dec}
}