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Serum lipid and lipoprotein concentrations following exposure to ozone

Journal Article:

Abstract

The effects of exposure to ozone (O/sub 3/) on concentrations of serum lipids and lipoproteins were investigated. Male and female guinea pigs were exposed to O/sub 3/ at 1 ppm for two weeks. Serum concentrations of cholesterol, triglycerides, low density (LDL) and very low density (VLDL) lipoproteins were elevated after O/sub 3/ exposure, particularly in males. During O/sub 3/ exposure the food intake per day decreased (for a constant body weight), suggesting that metabolic rate and possibly basal metabolic rate was lower. Lung wet weights increased during O/sub 3/ exposure by 87% for males and 45% for females. When individual lung weight/body weight ratios were correlated with cholesterol and LDL values from the same animal, a high correlation is found for males (r . 0.81, P less than 0.05), suggesting that there may be a relationship between lipoprotein elevations and lung damage for males. Because elevated concentrations of lipids and lipoproteins in humans increase the risk of coronary heart disease (CHD), the lipoprotein results suggest that an epidemiological study of the incidence of CHD with metropolitan O/sub 3/ levels may be warranted.
Publication Date:
Jul 01, 1984
Product Type:
Journal Article
Reference Number:
ERA-10-043022; EDB-85-135025
Resource Relation:
Journal Name: J. Environ. Pathol., Toxicol. Oncol.; (Iceland); Journal Volume: 5:4-5
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; LUNGS; INJURIES; OZONE; METABOLISM; TOXICITY; BIOLOGICAL MODELS; CHOLESTEROL; GUINEA PIGS; LIPOPROTEINS; SEX DEPENDENCE; TRIGLYCERIDES; WEIGHT; ANIMALS; BODY; ESTERS; HYDROXY COMPOUNDS; LIPIDS; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RESPIRATORY SYSTEM; RODENTS; STEROIDS; STEROLS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)
OSTI ID:
5482989
Research Organizations:
Lawrence Berkeley Lab., CA
Country of Origin:
Iceland
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JEPOE
Submitting Site:
HEDB
Size:
Pages: 165-173
Announcement Date:

Journal Article:

Citation Formats

Vaughan, W J, Adamson, G L, Lindgren, F T, and Schooley, J.C. Serum lipid and lipoprotein concentrations following exposure to ozone. Iceland: N. p., 1984. Web.
Vaughan, W J, Adamson, G L, Lindgren, F T, & Schooley, J.C. Serum lipid and lipoprotein concentrations following exposure to ozone. Iceland.
Vaughan, W J, Adamson, G L, Lindgren, F T, and Schooley, J.C. 1984. "Serum lipid and lipoprotein concentrations following exposure to ozone." Iceland.
@misc{etde_5482989,
title = {Serum lipid and lipoprotein concentrations following exposure to ozone}
author = {Vaughan, W J, Adamson, G L, Lindgren, F T, and Schooley, J.C.}
abstractNote = {The effects of exposure to ozone (O/sub 3/) on concentrations of serum lipids and lipoproteins were investigated. Male and female guinea pigs were exposed to O/sub 3/ at 1 ppm for two weeks. Serum concentrations of cholesterol, triglycerides, low density (LDL) and very low density (VLDL) lipoproteins were elevated after O/sub 3/ exposure, particularly in males. During O/sub 3/ exposure the food intake per day decreased (for a constant body weight), suggesting that metabolic rate and possibly basal metabolic rate was lower. Lung wet weights increased during O/sub 3/ exposure by 87% for males and 45% for females. When individual lung weight/body weight ratios were correlated with cholesterol and LDL values from the same animal, a high correlation is found for males (r . 0.81, P less than 0.05), suggesting that there may be a relationship between lipoprotein elevations and lung damage for males. Because elevated concentrations of lipids and lipoproteins in humans increase the risk of coronary heart disease (CHD), the lipoprotein results suggest that an epidemiological study of the incidence of CHD with metropolitan O/sub 3/ levels may be warranted.}
journal = {J. Environ. Pathol., Toxicol. Oncol.; (Iceland)}
volume = {5:4-5}
journal type = {AC}
place = {Iceland}
year = {1984}
month = {Jul}
}