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Diminished hepatic insulin removal in obesity

Journal Article:

Abstract

Peripheral insulin and C-peptide levels during oral glucose load were measured in 20 obese and 23 normal weight nondiabetic subjects. The fasting C-peptide to insulin molar ratios (Cp/I), as well as the relation between incremental areas of the two polypeptides (ACp-AI)/ACp, were used as relative measures of the hepatic insulin extraction (HIE). The insulin and C-peptide basal levels as well as incremental areas under plasma curves were higher in the obese subjects (P<0.001). HIE was lower in obeses than in controls assessed in the fasting state (P<0.05), as well as after glucose load (P<0.001). Nevertheless, obeses and controls with similar insulin fasting levels showed identical hepatic insulin extraction in fasting or after glucose load. HIE was independent of obesity degree, but was related to insulin basal levels (r=-0.60, P<0.01). This study suggests the hypothesis that the decreased hepatic insulin extraction in obeses is a result of the chronically increased insulin delivery to the liver and is not a consequence of obesity, although a contributory role cannot be ruled out.
Publication Date:
Jan 01, 1986
Product Type:
Journal Article
Reference Number:
AIX-19-028077; EDB-88-068486
Resource Relation:
Journal Name: J. Nucl. Med. Allied Sci.; (Italy); Journal Volume: 30:1
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; METABOLIC DISEASES; INSULIN; RADIOIMMUNOASSAY; BASAL METABOLISM; GLUCOSE; INTAKE; PANCREAS; ALDEHYDES; BODY; CARBOHYDRATES; DIGESTIVE SYSTEM; DISEASES; ENDOCRINE GLANDS; GLANDS; HEXOSES; HORMONES; IMMUNOASSAY; IMMUNOLOGY; ISOTOPE APPLICATIONS; METABOLISM; MONOSACCHARIDES; ORGANIC COMPOUNDS; ORGANS; PEPTIDE HORMONES; RADIOASSAY; RADIOIMMUNOLOGY; SACCHARIDES; TRACER TECHNIQUES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5480757
Research Organizations:
Navarra Univ., Pamplona (Spain). Faculdad de Medicina
Country of Origin:
Italy
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: JNMSD
Submitting Site:
INIS
Size:
Pages: 37-43
Announcement Date:
Mar 01, 1988

Journal Article:

Citation Formats

Cano, I, Salvador, J, Rodriguez, R, Arraiza, M C, Goena, M, Barberia, J J, and Moncada, E. Diminished hepatic insulin removal in obesity. Italy: N. p., 1986. Web.
Cano, I, Salvador, J, Rodriguez, R, Arraiza, M C, Goena, M, Barberia, J J, & Moncada, E. Diminished hepatic insulin removal in obesity. Italy.
Cano, I, Salvador, J, Rodriguez, R, Arraiza, M C, Goena, M, Barberia, J J, and Moncada, E. 1986. "Diminished hepatic insulin removal in obesity." Italy.
@misc{etde_5480757,
title = {Diminished hepatic insulin removal in obesity}
author = {Cano, I, Salvador, J, Rodriguez, R, Arraiza, M C, Goena, M, Barberia, J J, and Moncada, E}
abstractNote = {Peripheral insulin and C-peptide levels during oral glucose load were measured in 20 obese and 23 normal weight nondiabetic subjects. The fasting C-peptide to insulin molar ratios (Cp/I), as well as the relation between incremental areas of the two polypeptides (ACp-AI)/ACp, were used as relative measures of the hepatic insulin extraction (HIE). The insulin and C-peptide basal levels as well as incremental areas under plasma curves were higher in the obese subjects (P<0.001). HIE was lower in obeses than in controls assessed in the fasting state (P<0.05), as well as after glucose load (P<0.001). Nevertheless, obeses and controls with similar insulin fasting levels showed identical hepatic insulin extraction in fasting or after glucose load. HIE was independent of obesity degree, but was related to insulin basal levels (r=-0.60, P<0.01). This study suggests the hypothesis that the decreased hepatic insulin extraction in obeses is a result of the chronically increased insulin delivery to the liver and is not a consequence of obesity, although a contributory role cannot be ruled out.}
journal = {J. Nucl. Med. Allied Sci.; (Italy)}
volume = {30:1}
journal type = {AC}
place = {Italy}
year = {1986}
month = {Jan}
}