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Subcellular distribution of /sup 111/In and /sup 169/Yb in tumor and liver

Journal Article:

Abstract

Subcellular distribution of /sup 111/In and /sup 169/Yb was quantitatively determined to evaluate the role of the lysosome in accumulation of these nuclides in malignant tumor tissue and in the liver using three different tumor models and the host liver. In Yoshida sarcoma and Ehrlich tumor, most of the radioactivity of these nuclides was localized in the supernatant fraction, and only a small amount of radioactivity was localized in the mitochondrial fraction, which contains lysosomes. In the liver, most of the radioactivity was concentrated in the mitochondrial fraction. The radioactivity of this fraction increased with time after the administration of these nuclides and reached approximately 50% of the total radioactivity within 24 h. In the case of hepatoma AH109A, radioactivity of the mitochondrial fraction increased with time after administration, and about 30% of the total radioactivity was concentrated in this fraction after 24 h. It is concluded that the lysosome does not play a major role in the tumor concentration of these nuclides, although it may play an important role in their liver concentration. In the case of hepatoma AH109A, it is pressumed that lysosome plays a considerably important role in the tumor concentration of these nuclides, hepatoma AH109A possessing  More>>
Publication Date:
May 01, 1981
Product Type:
Journal Article
Reference Number:
EDB-82-085442
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 6:5
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; EXPERIMENTAL NEOPLASMS; RADIONUCLIDE KINETICS; RADIOPHARMACEUTICALS; BIOLOGICAL ACCUMULATION; CELL CONSTITUENTS; CITRATES; INDIUM 111; LIVER; LYSOSOMES; MICE; MITOCHONDRIA; NEOPLASMS; RATS; TIME DEPENDENCE; YTTERBIUM 169; ANIMALS; BETA DECAY RADIOISOTOPES; BODY; CARBOXYLIC ACID SALTS; DAYS LIVING RADIOISOTOPES; DIGESTIVE SYSTEM; DISEASES; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; GLANDS; INDIUM ISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LABELLED COMPOUNDS; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-EVEN NUCLEI; ORGANOIDS; ORGANS; RADIOISOTOPES; RARE EARTH ISOTOPES; RARE EARTH NUCLEI; RODENTS; VERTEBRATES; YTTERBIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5479058
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
HEDB
Size:
Pages: 221-226
Announcement Date:

Journal Article:

Citation Formats

Ando, A, Ando, I, Takeshita, M, Hiraki, T, and Hisada, K. Subcellular distribution of /sup 111/In and /sup 169/Yb in tumor and liver. Germany: N. p., 1981. Web.
Ando, A, Ando, I, Takeshita, M, Hiraki, T, & Hisada, K. Subcellular distribution of /sup 111/In and /sup 169/Yb in tumor and liver. Germany.
Ando, A, Ando, I, Takeshita, M, Hiraki, T, and Hisada, K. 1981. "Subcellular distribution of /sup 111/In and /sup 169/Yb in tumor and liver." Germany.
@misc{etde_5479058,
title = {Subcellular distribution of /sup 111/In and /sup 169/Yb in tumor and liver}
author = {Ando, A, Ando, I, Takeshita, M, Hiraki, T, and Hisada, K}
abstractNote = {Subcellular distribution of /sup 111/In and /sup 169/Yb was quantitatively determined to evaluate the role of the lysosome in accumulation of these nuclides in malignant tumor tissue and in the liver using three different tumor models and the host liver. In Yoshida sarcoma and Ehrlich tumor, most of the radioactivity of these nuclides was localized in the supernatant fraction, and only a small amount of radioactivity was localized in the mitochondrial fraction, which contains lysosomes. In the liver, most of the radioactivity was concentrated in the mitochondrial fraction. The radioactivity of this fraction increased with time after the administration of these nuclides and reached approximately 50% of the total radioactivity within 24 h. In the case of hepatoma AH109A, radioactivity of the mitochondrial fraction increased with time after administration, and about 30% of the total radioactivity was concentrated in this fraction after 24 h. It is concluded that the lysosome does not play a major role in the tumor concentration of these nuclides, although it may play an important role in their liver concentration. In the case of hepatoma AH109A, it is pressumed that lysosome plays a considerably important role in the tumor concentration of these nuclides, hepatoma AH109A possessing some residual features of the liver.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {6:5}
journal type = {AC}
place = {Germany}
year = {1981}
month = {May}
}