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How does the extracellular matrix direct gene expression

Abstract

Based on the existing literature, a model is presented that postulates a ''dynamic reciprocity'' between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the nuclear matrix on the other hand. The ECM is postulated to exert physical and chemical influences on the geometry and the biochemistry of the cell via transmembrane receptors so as to alter the pattern of gene expression by changing the association of the cytoskeleton with mRNA and the interaction of the chromatin with the nuclear matrix. This, in turn, would affect the ECM, which would affect the cell.
Publication Date:
Jan 01, 1982
Product Type:
Journal Article
Reference Number:
EDB-84-024486
Resource Relation:
Journal Name: J. Theor. Biol.; (United Kingdom); Journal Volume: 99
Subject:
59 BASIC BIOLOGICAL SCIENCES; GENOTYPE; EVALUATION; CELL MEMBRANES; CHROMATIN; MESSENGER-RNA; PHENOTYPE; RECEPTORS; CELL CONSTITUENTS; MEMBRANES; NUCLEIC ACIDS; ORGANIC COMPOUNDS; RNA; 550400* - Genetics
OSTI ID:
5478346
Research Organizations:
Univ. of California, Berkeley
Country of Origin:
United Kingdom
Language:
English
Contract Number:
AC03-76SF00098
Other Identifying Numbers:
Journal ID: CODEN: JTBIA
Submitting Site:
HEDB
Size:
Pages: 31-68
Announcement Date:
Jan 01, 1984

Citation Formats

Bissell, M J, Hall, H G, and Parry, G. How does the extracellular matrix direct gene expression. United Kingdom: N. p., 1982. Web. doi:10.1016/0022-5193(82)90388-5.
Bissell, M J, Hall, H G, & Parry, G. How does the extracellular matrix direct gene expression. United Kingdom. doi:10.1016/0022-5193(82)90388-5.
Bissell, M J, Hall, H G, and Parry, G. 1982. "How does the extracellular matrix direct gene expression." United Kingdom. doi:10.1016/0022-5193(82)90388-5. https://www.osti.gov/servlets/purl/10.1016/0022-5193(82)90388-5.
@misc{etde_5478346,
title = {How does the extracellular matrix direct gene expression}
author = {Bissell, M J, Hall, H G, and Parry, G}
abstractNote = {Based on the existing literature, a model is presented that postulates a ''dynamic reciprocity'' between the extracellular matrix (ECM) on the one hand and the cytoskeleton and the nuclear matrix on the other hand. The ECM is postulated to exert physical and chemical influences on the geometry and the biochemistry of the cell via transmembrane receptors so as to alter the pattern of gene expression by changing the association of the cytoskeleton with mRNA and the interaction of the chromatin with the nuclear matrix. This, in turn, would affect the ECM, which would affect the cell.}
doi = {10.1016/0022-5193(82)90388-5}
journal = {J. Theor. Biol.; (United Kingdom)}
volume = {99}
journal type = {AC}
place = {United Kingdom}
year = {1982}
month = {Jan}
}