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Carcinogenicity of soil extracts

Journal Article:

Abstract

A total of 270 3-mo-old mice, hybrids of the C57BL and CBA strains which are highly susceptible to carcinogens, were painted on the skin (2-3 admin./week) with 3-4 drops of (1) a concentrated benzene extract of soil taken near a petroleum refinery with a 3,4 benzpyrene (BP) content of 0.22%; (2) a 0.22% soln of pure BP in benzene; (3) a concentrated benzene extract of soil taken from an old residential area of Moscow (BP content 0.0004%); (4) a 0.0004% BP soln in benzene; and (5) pure benzene. Only mice in the first 2 groups developed tumors. In group (1), 8 mice had papillomas, 46 had skin cancer, 1 had a sarcoma and 2 had plasmocytomas. In group (2) all 60 animals had skin cancer. Lung metastases were present at autopsy in 5 mice in group (1) and in 10 mice in group (2); in some cases, these tumors were multiple. Lymph node metastases were found in 6 mice in group (1) and in 10 mice in group (2). Tumors developed more slowly in group (1) than in group (2).
Authors:
Publication Date:
Jan 01, 1970
Product Type:
Journal Article
Reference Number:
EDB-82-085813
Resource Relation:
Journal Name: Vopr. Onkol.; (USSR); Journal Volume: 16:3
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 02 PETROLEUM; BENZENE; CARCINOGENESIS; BENZOPYRENE; PETROLEUM REFINERIES; HEALTH HAZARDS; SOILS; LUNGS; LYMPH NODES; METASTASES; MICE; NEOPLASMS; SARCOMAS; SKIN; USSR; ANIMALS; AROMATICS; ASIA; BODY; CONDENSED AROMATICS; DISEASES; EASTERN EUROPE; EUROPE; HAZARDS; HYDROCARBONS; INDUSTRIAL PLANTS; LYMPHATIC SYSTEM; MAMMALS; ORGANIC COMPOUNDS; ORGANS; PATHOGENESIS; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987); 020600 - Petroleum- Health & Safety
OSTI ID:
5477200
Research Organizations:
Inst. of Experimental Clinical Oncology, Moscow, USSR
Country of Origin:
USSR
Language:
Russian
Other Identifying Numbers:
Journal ID: CODEN: VOONA
Submitting Site:
HEDB
Size:
Pages: 74-78
Announcement Date:
May 01, 1982

Journal Article:

Citation Formats

Shcherbak, N P. Carcinogenicity of soil extracts. USSR: N. p., 1970. Web.
Shcherbak, N P. Carcinogenicity of soil extracts. USSR.
Shcherbak, N P. 1970. "Carcinogenicity of soil extracts." USSR.
@misc{etde_5477200,
title = {Carcinogenicity of soil extracts}
author = {Shcherbak, N P}
abstractNote = {A total of 270 3-mo-old mice, hybrids of the C57BL and CBA strains which are highly susceptible to carcinogens, were painted on the skin (2-3 admin./week) with 3-4 drops of (1) a concentrated benzene extract of soil taken near a petroleum refinery with a 3,4 benzpyrene (BP) content of 0.22%; (2) a 0.22% soln of pure BP in benzene; (3) a concentrated benzene extract of soil taken from an old residential area of Moscow (BP content 0.0004%); (4) a 0.0004% BP soln in benzene; and (5) pure benzene. Only mice in the first 2 groups developed tumors. In group (1), 8 mice had papillomas, 46 had skin cancer, 1 had a sarcoma and 2 had plasmocytomas. In group (2) all 60 animals had skin cancer. Lung metastases were present at autopsy in 5 mice in group (1) and in 10 mice in group (2); in some cases, these tumors were multiple. Lymph node metastases were found in 6 mice in group (1) and in 10 mice in group (2). Tumors developed more slowly in group (1) than in group (2).}
journal = {Vopr. Onkol.; (USSR)}
volume = {16:3}
journal type = {AC}
place = {USSR}
year = {1970}
month = {Jan}
}