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Breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. Pathologic features

Journal Article:

Abstract

The pathological features of 161 cases of breast cancer --7% noninfiltrating carcinoma, 47% nonspecific infiltrating duct carcinoma, 21% nonfiltrating papillary duct carcinoma, 7% comedo carcinoma, 6% medullary carcinoma, 6% colloid carcinoma, 4% lobular carcinoma, and 2% sarcoma-- were investigated and their relation to irradiation dosage due to the atomic bomb was studied. Irradiation dosage was estimated from T65 dosage, the total dosage of ..gamma..-rays and neutrons in unshielded tissue. However, there was no relation between the dosage and any specific tissue type. Breast cancers were classified as either type I, type II, or type III according to the histological grade, and each grade was divided according to the degree of differentiation, multiplicity, and mitiotic activity. The pathological characteristics, lymphatic infiltration, fibrosis, necrosis, localization, calcification, and vascular, perineurial, muscular, and dermal invasion were investigated in each case. The histological grade and the incidence of localized invasion, necrosis, localization, and calcification were lower in the patients who were irradiated with more than 50 rad than in those who were not irradiated. The absolute risk rate for breast cancer was estimated to increase by 1.9 cases/100,000 rad from 1950 to 1969. This increase was much smaller than that estimated from x-ray irradiation during  More>>
Authors:
McGregor, D H; [1]  Land, C E; Choi, K; Tokuoka, S; Liu, P I
  1. Veterans Administration Hospital, Kansas (USA)
Publication Date:
Jan 01, 1981
Product Type:
Journal Article
Reference Number:
AIX-13-674858; EDB-82-105370
Resource Relation:
Journal Name: Hiroshima Igaku; (Japan); Journal Volume: 34:1
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; A-BOMB SURVIVORS; CARCINOMAS; MAMMARY GLANDS; DELAYED RADIATION EFFECTS; AGE GROUPS; CARCINOGENESIS; ENDOCRINE GLANDS; FIBROSIS; HIROSHIMA; LYMPHOCYTES; MEDICAL SURVEILLANCE; METASTASES; NAGASAKI; NECROSIS; PATIENTS; RADIATION DOSES; ANIMAL CELLS; ASIA; BIOLOGICAL EFFECTS; BIOLOGICAL MATERIALS; BIOLOGICAL RADIATION EFFECTS; BLOOD; BLOOD CELLS; BODY; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; DOSES; GLANDS; HUMAN POPULATIONS; JAPAN; LEUKOCYTES; MATERIALS; NEOPLASMS; ORGANS; PATHOGENESIS; PATHOLOGICAL CHANGES; POPULATIONS; RADIATION EFFECTS; SOMATIC CELLS; SURVEILLANCE; 560151* - Radiation Effects on Animals- Man
OSTI ID:
5475076
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: HIRGA
Submitting Site:
HEDB
Size:
Pages: 76-86
Announcement Date:

Journal Article:

Citation Formats

McGregor, D H, Land, C E, Choi, K, Tokuoka, S, and Liu, P I. Breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. Pathologic features. Japan: N. p., 1981. Web.
McGregor, D H, Land, C E, Choi, K, Tokuoka, S, & Liu, P I. Breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. Pathologic features. Japan.
McGregor, D H, Land, C E, Choi, K, Tokuoka, S, and Liu, P I. 1981. "Breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. Pathologic features." Japan.
@misc{etde_5475076,
title = {Breast cancer among atomic bomb survivors, Hiroshima and Nagasaki, 1950-69. Pathologic features}
author = {McGregor, D H, Land, C E, Choi, K, Tokuoka, S, and Liu, P I}
abstractNote = {The pathological features of 161 cases of breast cancer --7% noninfiltrating carcinoma, 47% nonspecific infiltrating duct carcinoma, 21% nonfiltrating papillary duct carcinoma, 7% comedo carcinoma, 6% medullary carcinoma, 6% colloid carcinoma, 4% lobular carcinoma, and 2% sarcoma-- were investigated and their relation to irradiation dosage due to the atomic bomb was studied. Irradiation dosage was estimated from T65 dosage, the total dosage of ..gamma..-rays and neutrons in unshielded tissue. However, there was no relation between the dosage and any specific tissue type. Breast cancers were classified as either type I, type II, or type III according to the histological grade, and each grade was divided according to the degree of differentiation, multiplicity, and mitiotic activity. The pathological characteristics, lymphatic infiltration, fibrosis, necrosis, localization, calcification, and vascular, perineurial, muscular, and dermal invasion were investigated in each case. The histological grade and the incidence of localized invasion, necrosis, localization, and calcification were lower in the patients who were irradiated with more than 50 rad than in those who were not irradiated. The absolute risk rate for breast cancer was estimated to increase by 1.9 cases/100,000 rad from 1950 to 1969. This increase was much smaller than that estimated from x-ray irradiation during medical treatment in North America. The dose response curves at Hiroshima and Nagasaki were similar and fitted well with a linear model, suggesting that the effect of ..gamma..-rays was analogous to that of neutrons in inducing cancer. The problems involved in the histological classification of breast cancer and the histological differences between cancer patients in Japan and in the U.S.A. were discussed.}
journal = {Hiroshima Igaku; (Japan)}
volume = {34:1}
journal type = {AC}
place = {Japan}
year = {1981}
month = {Jan}
}