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Movement disorders induced in monkeys by chronic haloperidol treatment

Abstract

After several months of treatment, Cebus apella, Cebus albifrons, and Saimiri sciurea monkeys maintained on haloperidol, in doses of 0.5 or 1.0 mg/kg orally 5 days per week, began to display severe movement disorders, typically 1 to 6 h post-drug. Cebus monkeys exhibited violent, uncontrolled movements that flung the animals about the cage. Such episodes usually lasted only a few minutes, recurring several times during the period following drug ingestion. Writhing and bizarre postures dominated the response in S. sciurea. Cessation of drug treatment produced no distinctive after-effects. When tested as long as 508 days after the last administration, however, Cebus monkeys responded to haloperidol with several episodes of hyperkinesis, even at challenge doses considerably lower than those in the original treatment.
Publication Date:
Jan 01, 1977
Product Type:
Journal Article
Reference Number:
ERA-05-019577; EDB-80-051372
Resource Relation:
Journal Name: Psychopharmacology (Berlin); (Germany, Federal Republic of); Journal Volume: 53
Subject:
59 BASIC BIOLOGICAL SCIENCES; BEHAVIOR; TOXICITY; DOSE-RESPONSE RELATIONSHIPS; DRUGS; MONKEYS; NERVOUS SYSTEM DISEASES; ANIMALS; DISEASES; MAMMALS; PRIMATES; VERTEBRATES; 550100* - Behavioral Biology
OSTI ID:
5465251
Research Organizations:
Univ. of Rochester, NY
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: PSCHD
Submitting Site:
TIC
Size:
Pages: 289-293
Announcement Date:
May 01, 1980

Citation Formats

Weiss, B, Santelli, S, and Lusink, G. Movement disorders induced in monkeys by chronic haloperidol treatment. Germany: N. p., 1977. Web.
Weiss, B, Santelli, S, & Lusink, G. Movement disorders induced in monkeys by chronic haloperidol treatment. Germany.
Weiss, B, Santelli, S, and Lusink, G. 1977. "Movement disorders induced in monkeys by chronic haloperidol treatment." Germany.
@misc{etde_5465251,
title = {Movement disorders induced in monkeys by chronic haloperidol treatment}
author = {Weiss, B, Santelli, S, and Lusink, G}
abstractNote = {After several months of treatment, Cebus apella, Cebus albifrons, and Saimiri sciurea monkeys maintained on haloperidol, in doses of 0.5 or 1.0 mg/kg orally 5 days per week, began to display severe movement disorders, typically 1 to 6 h post-drug. Cebus monkeys exhibited violent, uncontrolled movements that flung the animals about the cage. Such episodes usually lasted only a few minutes, recurring several times during the period following drug ingestion. Writhing and bizarre postures dominated the response in S. sciurea. Cessation of drug treatment produced no distinctive after-effects. When tested as long as 508 days after the last administration, however, Cebus monkeys responded to haloperidol with several episodes of hyperkinesis, even at challenge doses considerably lower than those in the original treatment.}
journal = {Psychopharmacology (Berlin); (Germany, Federal Republic of)}
volume = {53}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Jan}
}