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Intestinal enzyme distribution after supralethal irradiation

Abstract

The activity of some intestinal enzymes has been studied after 2 kR irradiation. Brush border enzymes, maltase and leucineaminopeptidase (LAP) show an increase 20 hours after irradiation, while after 72 hours their activities are reduced to very low levels. Lysosomal enzymes show a completely different behaviour: acid phosphatase activity increases only 72 hours after irradiation, whereas ..beta.. glucuronidase increases significantly after 20 hours and reaches values two or three times higher than controls after 72 hours. The histologic picture at the first interval after irradiation shows gross alterations in the crypt region, but the villi appear nearly normal. Seventy-two hours after irradiation the whole epithelium is affected and very numerous leukocytes are present in the stroma.
Authors:
Becciolini, A; Gerber, G B; Buracchi, A; Deroo, J; [1]  Centre d'Etude de l'Energie Nucleaire, Mol (Belgium). Dept. de Radiobiologie)
  1. Florence Univ. (Italy). Istituto di Radiologia
Publication Date:
Jul 01, 1977
Product Type:
Journal Article
Reference Number:
AIX-08-340463; EDB-78-023372
Resource Relation:
Journal Name: Strahlentherapie; (Germany, Federal Republic of); Journal Volume: 153:7
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; ENZYMES; BIOLOGICAL RADIATION EFFECTS; INTESTINES; CATALYSIS; EPITHELIUM; HISTOLOGY; METABOLISM; RATS; SUPRALETHAL IRRADIATION; WHOLE-BODY IRRADIATION; X RADIATION; ANIMALS; BIOLOGICAL EFFECTS; BODY; DIGESTIVE SYSTEM; ELECTROMAGNETIC RADIATION; EXTERNAL IRRADIATION; GASTROINTESTINAL TRACT; IONIZING RADIATIONS; IRRADIATION; MAMMALS; ORGANS; RADIATION EFFECTS; RADIATIONS; RODENTS; TISSUES; VERTEBRATES; 560152* - Radiation Effects on Animals- Animals
OSTI ID:
5443451
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: STRAA
Submitting Site:
INIS
Size:
Pages: 485-488
Announcement Date:
Nov 01, 1977

Citation Formats

Becciolini, A, Gerber, G B, Buracchi, A, Deroo, J, and Centre d'Etude de l'Energie Nucleaire, Mol (Belgium). Dept. de Radiobiologie). Intestinal enzyme distribution after supralethal irradiation. Germany: N. p., 1977. Web.
Becciolini, A, Gerber, G B, Buracchi, A, Deroo, J, & Centre d'Etude de l'Energie Nucleaire, Mol (Belgium). Dept. de Radiobiologie). Intestinal enzyme distribution after supralethal irradiation. Germany.
Becciolini, A, Gerber, G B, Buracchi, A, Deroo, J, and Centre d'Etude de l'Energie Nucleaire, Mol (Belgium). Dept. de Radiobiologie). 1977. "Intestinal enzyme distribution after supralethal irradiation." Germany.
@misc{etde_5443451,
title = {Intestinal enzyme distribution after supralethal irradiation}
author = {Becciolini, A, Gerber, G B, Buracchi, A, Deroo, J, and Centre d'Etude de l'Energie Nucleaire, Mol (Belgium). Dept. de Radiobiologie)}
abstractNote = {The activity of some intestinal enzymes has been studied after 2 kR irradiation. Brush border enzymes, maltase and leucineaminopeptidase (LAP) show an increase 20 hours after irradiation, while after 72 hours their activities are reduced to very low levels. Lysosomal enzymes show a completely different behaviour: acid phosphatase activity increases only 72 hours after irradiation, whereas ..beta.. glucuronidase increases significantly after 20 hours and reaches values two or three times higher than controls after 72 hours. The histologic picture at the first interval after irradiation shows gross alterations in the crypt region, but the villi appear nearly normal. Seventy-two hours after irradiation the whole epithelium is affected and very numerous leukocytes are present in the stroma.}
journal = []
volume = {153:7}
journal type = {AC}
place = {Germany}
year = {1977}
month = {Jul}
}