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Myocardial scintigraphy with /sup 201/Tl and quantitative assessment of myocardial blood flow

Journal Article:

Abstract

A newly introduced radionuclide for myocardial imaging, /sup 201/Tl, was studied. Twenty-two subjects consisting of 7 normals, 12 with ischemic heart disease and 3 with hypertrophic cardiomyopathy (HCM) were selected. On intravenous administration of /sup 201/Tl(1.5 to 20. mCi), initial transit of the tracer through the heart, as well as subsequent uptake by the myocardium, were recorded by a scintillation camera. The later process showed the distribution of the myocardial blood flow (MBF). A normal myocardial scintigraphy revealed the left-sided myocardial mass predominantly, whereas the right side or the septum predominated in the case of tetralogy of fallot (T/F) or idiopathic hypertrophic subuaortic stenosis (IHSS). An ischemic or infarcted area of the myocardium in ischemic heart disease (IHD) was compatible with electrocardiographic findings, and revealed defects even in an equivocal case on ECG. Since the ratio of radioactivity taken up by the myocardium (U) to the total injected dosis (I) is assumed to be proportional to the fractional MBF of cardiac output (CO), MBF/CO is calculated by ratio of the radioactivity selected from myocardial region on the later recording to that from the entire region on the initial transit of the tracer bolus. The average MBF/CO of normals was 4.4  More>>
Authors:
Ishii, Y; Kanbara, H; Yonekura, Y; Kadota, K; Fujita, T [1] 
  1. Kyoto Univ. (Japan). Faculty of Medicine
Publication Date:
Dec 01, 1976
Product Type:
Journal Article
Reference Number:
AIX-08-343433; EDB-78-023127
Resource Relation:
Journal Name: Kaku Igaku; (Japan); Journal Volume: 13:6
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; BLOOD FLOW; MEASURING METHODS; MYOCARDIUM; SCINTISCANNING; THALLIUM 201; IMAGES; INTRAVENOUS INJECTION; ISCHEMIA; ANEMIAS; BETA DECAY RADIOISOTOPES; BODY; CARDIOVASCULAR DISEASES; CARDIOVASCULAR SYSTEM; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ELECTRON CAPTURE RADIOISOTOPES; HEART; HEAVY NUCLEI; HEMIC DISEASES; INJECTION; INTAKE; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MUSCLES; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; SECONDS LIVING RADIOISOTOPES; SYMPTOMS; THALLIUM ISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5436345
Country of Origin:
Japan
Language:
Japanese
Other Identifying Numbers:
Journal ID: CODEN: KAIGB
Submitting Site:
INIS
Size:
Pages: 787-797
Announcement Date:

Journal Article:

Citation Formats

Ishii, Y, Kanbara, H, Yonekura, Y, Kadota, K, and Fujita, T. Myocardial scintigraphy with /sup 201/Tl and quantitative assessment of myocardial blood flow. Japan: N. p., 1976. Web.
Ishii, Y, Kanbara, H, Yonekura, Y, Kadota, K, & Fujita, T. Myocardial scintigraphy with /sup 201/Tl and quantitative assessment of myocardial blood flow. Japan.
Ishii, Y, Kanbara, H, Yonekura, Y, Kadota, K, and Fujita, T. 1976. "Myocardial scintigraphy with /sup 201/Tl and quantitative assessment of myocardial blood flow." Japan.
@misc{etde_5436345,
title = {Myocardial scintigraphy with /sup 201/Tl and quantitative assessment of myocardial blood flow}
author = {Ishii, Y, Kanbara, H, Yonekura, Y, Kadota, K, and Fujita, T}
abstractNote = {A newly introduced radionuclide for myocardial imaging, /sup 201/Tl, was studied. Twenty-two subjects consisting of 7 normals, 12 with ischemic heart disease and 3 with hypertrophic cardiomyopathy (HCM) were selected. On intravenous administration of /sup 201/Tl(1.5 to 20. mCi), initial transit of the tracer through the heart, as well as subsequent uptake by the myocardium, were recorded by a scintillation camera. The later process showed the distribution of the myocardial blood flow (MBF). A normal myocardial scintigraphy revealed the left-sided myocardial mass predominantly, whereas the right side or the septum predominated in the case of tetralogy of fallot (T/F) or idiopathic hypertrophic subuaortic stenosis (IHSS). An ischemic or infarcted area of the myocardium in ischemic heart disease (IHD) was compatible with electrocardiographic findings, and revealed defects even in an equivocal case on ECG. Since the ratio of radioactivity taken up by the myocardium (U) to the total injected dosis (I) is assumed to be proportional to the fractional MBF of cardiac output (CO), MBF/CO is calculated by ratio of the radioactivity selected from myocardial region on the later recording to that from the entire region on the initial transit of the tracer bolus. The average MBF/CO of normals was 4.4 +- 0.5%, IHD 4.0 +- 0.8% and HCM 5.5 +- 1.2%. On exercise loading, a significant increase of this value was observed in normals, whereas no change was observed in IHD.}
journal = {Kaku Igaku; (Japan)}
volume = {13:6}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Dec}
}