Abstract
The decrease of tyrosine hydroxylase activity in adrenal homogenate in scurvy was recovered after the administration of ascorbic acid. The causes of the increase in the enzyme activity after the administration of ascorbic acid have been studied. 1. No significant elevation in the enzyme activity was observed after the administration of reserpine to the scorbutic guinea pig. 2. A dose of metal chelating agent, ..cap alpha.., ..cap alpha..'-dipyridyl, prevented the ascorbic acid-induced or reserpine-induced increase in enzyme activity in the scorbutic and the nonscorbutic guinea pigs, respectively. 3. Tyrosine hydroxylase activity was partially recovered by the administration of FeSO/sub 4/ to the scorbutic guinea pig. From these results, it became clear that the induction of tyrosine hydroxylase which was not observed in scurvy was due to the deficiency of Fe/sup 2 +/. These results suggested that ascorbic acid affected the induction of this enzyme via Fe/sup 2 +/.
Citation Formats
Nakashima, Y, Sanada, H, Suzue, R, and Kawada, S.
Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.
Japan: N. p.,
1976.
Web.
Nakashima, Y, Sanada, H, Suzue, R, & Kawada, S.
Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig.
Japan.
Nakashima, Y, Sanada, H, Suzue, R, and Kawada, S.
1976.
"Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig."
Japan.
@misc{etde_5435881,
title = {Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig}
author = {Nakashima, Y, Sanada, H, Suzue, R, and Kawada, S}
abstractNote = {The decrease of tyrosine hydroxylase activity in adrenal homogenate in scurvy was recovered after the administration of ascorbic acid. The causes of the increase in the enzyme activity after the administration of ascorbic acid have been studied. 1. No significant elevation in the enzyme activity was observed after the administration of reserpine to the scorbutic guinea pig. 2. A dose of metal chelating agent, ..cap alpha.., ..cap alpha..'-dipyridyl, prevented the ascorbic acid-induced or reserpine-induced increase in enzyme activity in the scorbutic and the nonscorbutic guinea pigs, respectively. 3. Tyrosine hydroxylase activity was partially recovered by the administration of FeSO/sub 4/ to the scorbutic guinea pig. From these results, it became clear that the induction of tyrosine hydroxylase which was not observed in scurvy was due to the deficiency of Fe/sup 2 +/. These results suggested that ascorbic acid affected the induction of this enzyme via Fe/sup 2 +/.}
journal = []
volume = {22:5}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Oct}
}
title = {Role of ascorbic acid on tyrosine hydroxylase activity in the adrenal gland of guinea pig}
author = {Nakashima, Y, Sanada, H, Suzue, R, and Kawada, S}
abstractNote = {The decrease of tyrosine hydroxylase activity in adrenal homogenate in scurvy was recovered after the administration of ascorbic acid. The causes of the increase in the enzyme activity after the administration of ascorbic acid have been studied. 1. No significant elevation in the enzyme activity was observed after the administration of reserpine to the scorbutic guinea pig. 2. A dose of metal chelating agent, ..cap alpha.., ..cap alpha..'-dipyridyl, prevented the ascorbic acid-induced or reserpine-induced increase in enzyme activity in the scorbutic and the nonscorbutic guinea pigs, respectively. 3. Tyrosine hydroxylase activity was partially recovered by the administration of FeSO/sub 4/ to the scorbutic guinea pig. From these results, it became clear that the induction of tyrosine hydroxylase which was not observed in scurvy was due to the deficiency of Fe/sup 2 +/. These results suggested that ascorbic acid affected the induction of this enzyme via Fe/sup 2 +/.}
journal = []
volume = {22:5}
journal type = {AC}
place = {Japan}
year = {1976}
month = {Oct}
}