Abstract
Rats were injected intramuscularly with /sup 239/Pu in the form of citrate or nitrate and the effect of daily subcutaneous injections of 30 ..mu..mole kg/sup -1/ Ca-DTPA was compared with that of higher Zn-DTPA doses administered in single daily injections or in a continuous infusion. Treatment reduced uptake by the organs of /sup 239/Pu, but did not influence its translocation. When /sup 239/Pu was injected as citrate, it was not only more readily translocated, but also more easily chelated than after injection as /sup 239/Pu-nitrate. The higher decorporation effectiveness of Ca-DTPA could be compensated only by increasing the Zn-DTPA dosage by a factor of 33. Maintenance of a sustained Zn-DTPA blood level proved to be of little significance. Thus, from the decorporation point of view, there is at present no reason to replace single daily injections of Ca-DTPA by Zn-DTPA during early treatment of incorporated plutonium.
Gemenetzis, E;
Volf, V
[1]
- Kernforschungszentrum Karlsruhe (Germany, F.R.). Inst. fuer Strahlenbiologie
Citation Formats
Gemenetzis, E, and Volf, V.
DTPA treatment schedules for decorporation of /sup 239/Pu from simulated wounds.
United Kingdom: N. p.,
1977.
Web.
Gemenetzis, E, & Volf, V.
DTPA treatment schedules for decorporation of /sup 239/Pu from simulated wounds.
United Kingdom.
Gemenetzis, E, and Volf, V.
1977.
"DTPA treatment schedules for decorporation of /sup 239/Pu from simulated wounds."
United Kingdom.
@misc{etde_5433823,
title = {DTPA treatment schedules for decorporation of /sup 239/Pu from simulated wounds}
author = {Gemenetzis, E, and Volf, V}
abstractNote = {Rats were injected intramuscularly with /sup 239/Pu in the form of citrate or nitrate and the effect of daily subcutaneous injections of 30 ..mu..mole kg/sup -1/ Ca-DTPA was compared with that of higher Zn-DTPA doses administered in single daily injections or in a continuous infusion. Treatment reduced uptake by the organs of /sup 239/Pu, but did not influence its translocation. When /sup 239/Pu was injected as citrate, it was not only more readily translocated, but also more easily chelated than after injection as /sup 239/Pu-nitrate. The higher decorporation effectiveness of Ca-DTPA could be compensated only by increasing the Zn-DTPA dosage by a factor of 33. Maintenance of a sustained Zn-DTPA blood level proved to be of little significance. Thus, from the decorporation point of view, there is at present no reason to replace single daily injections of Ca-DTPA by Zn-DTPA during early treatment of incorporated plutonium.}
journal = []
volume = {32:6}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Jun}
}
title = {DTPA treatment schedules for decorporation of /sup 239/Pu from simulated wounds}
author = {Gemenetzis, E, and Volf, V}
abstractNote = {Rats were injected intramuscularly with /sup 239/Pu in the form of citrate or nitrate and the effect of daily subcutaneous injections of 30 ..mu..mole kg/sup -1/ Ca-DTPA was compared with that of higher Zn-DTPA doses administered in single daily injections or in a continuous infusion. Treatment reduced uptake by the organs of /sup 239/Pu, but did not influence its translocation. When /sup 239/Pu was injected as citrate, it was not only more readily translocated, but also more easily chelated than after injection as /sup 239/Pu-nitrate. The higher decorporation effectiveness of Ca-DTPA could be compensated only by increasing the Zn-DTPA dosage by a factor of 33. Maintenance of a sustained Zn-DTPA blood level proved to be of little significance. Thus, from the decorporation point of view, there is at present no reason to replace single daily injections of Ca-DTPA by Zn-DTPA during early treatment of incorporated plutonium.}
journal = []
volume = {32:6}
journal type = {AC}
place = {United Kingdom}
year = {1977}
month = {Jun}
}