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Radiometric titration of officinal radiopharmaceuticals using radioactive kryptonates as end-point indicators. I. Salicylic, acetylosalicylic, benzoic acids

Abstract

A method for the determination of salicylic, acetylsalicylic and benzoic acids in officinal pharmaceutical based on radiometric titration with 0.1 mol.l/sup -1/ NaOH was developed. The end-point was detected with the aid of radioactive glass kryptonate. After the end-point, the excess titrant attacks the glass surface layers and this results in releasing /sup 85/Kr, and consequently, in decreasing the radioactivity of the kryptonate employed. The radioactive kryptonate used as an indicator was prepared by the bombardment of glass with accelerated /sup 85/Kr ions. The developed method is simple, accurate and correct.
Authors:
Toelgyessy, J; Dillinger, P; [1]  Harangozo, M; Jombik, J [2] 
  1. Slovenska Vysoka Skola Technicka, Bratislava (Czechoslovakia). Chemickotechnologicka Fakulta
  2. Komenskeho Univ., Bratislava (Czechoslovakia). Farmaceuticka Fakulta
Publication Date:
Jan 01, 1980
Product Type:
Journal Article
Reference Number:
AIX-13-674156; EDB-82-103868
Resource Relation:
Journal Name: Farm. Obz.; (Czechoslovakia); Journal Volume: 49:11
Subject:
37 INORGANIC, ORGANIC, PHYSICAL AND ANALYTICAL CHEMISTRY; 62 RADIOLOGY AND NUCLEAR MEDICINE; ACETYLSALICYLIC ACID; RADIO-RELEASE ANALYSIS; TITRATION; BENZOIC ACID; SALICYLIC ACID; GLASS; INDICATORS; KRYPTON 85; KRYPTON COMPOUNDS; SODIUM HYDROXIDES; TRACER TECHNIQUES; ALKALI METAL COMPOUNDS; ANALGESICS; ANTIPYRETICS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; CARBOXYLIC ACIDS; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHEMICAL ANALYSIS; DRUGS; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; HYDROGEN COMPOUNDS; HYDROXIDES; HYDROXY ACIDS; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPE APPLICATIONS; ISOTOPES; KRYPTON ISOTOPES; MONOCARBOXYLIC ACIDS; NUCLEI; ORGANIC ACIDS; ORGANIC COMPOUNDS; OXYGEN COMPOUNDS; QUANTITATIVE CHEMICAL ANALYSIS; RADIOISOTOPES; RARE GAS COMPOUNDS; SODIUM COMPOUNDS; YEARS LIVING RADIOISOTOPES; 400103* - Radiometric & Radiochemical Procedures- (-1987); 550601 - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5412752
Country of Origin:
Serbia and Montenegro
Language:
Slovak
Other Identifying Numbers:
Journal ID: CODEN: FAOBA
Submitting Site:
HEDB
Size:
Pages: 497-502
Announcement Date:
May 01, 1982

Citation Formats

Toelgyessy, J, Dillinger, P, Harangozo, M, and Jombik, J. Radiometric titration of officinal radiopharmaceuticals using radioactive kryptonates as end-point indicators. I. Salicylic, acetylosalicylic, benzoic acids. Serbia and Montenegro: N. p., 1980. Web.
Toelgyessy, J, Dillinger, P, Harangozo, M, & Jombik, J. Radiometric titration of officinal radiopharmaceuticals using radioactive kryptonates as end-point indicators. I. Salicylic, acetylosalicylic, benzoic acids. Serbia and Montenegro.
Toelgyessy, J, Dillinger, P, Harangozo, M, and Jombik, J. 1980. "Radiometric titration of officinal radiopharmaceuticals using radioactive kryptonates as end-point indicators. I. Salicylic, acetylosalicylic, benzoic acids." Serbia and Montenegro.
@misc{etde_5412752,
title = {Radiometric titration of officinal radiopharmaceuticals using radioactive kryptonates as end-point indicators. I. Salicylic, acetylosalicylic, benzoic acids}
author = {Toelgyessy, J, Dillinger, P, Harangozo, M, and Jombik, J}
abstractNote = {A method for the determination of salicylic, acetylsalicylic and benzoic acids in officinal pharmaceutical based on radiometric titration with 0.1 mol.l/sup -1/ NaOH was developed. The end-point was detected with the aid of radioactive glass kryptonate. After the end-point, the excess titrant attacks the glass surface layers and this results in releasing /sup 85/Kr, and consequently, in decreasing the radioactivity of the kryptonate employed. The radioactive kryptonate used as an indicator was prepared by the bombardment of glass with accelerated /sup 85/Kr ions. The developed method is simple, accurate and correct.}
journal = []
volume = {49:11}
journal type = {AC}
place = {Serbia and Montenegro}
year = {1980}
month = {Jan}
}