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Dry aerosol of monodisperse millimicrospheres for ventilation imaging: Production, delivery system, and clinical results in comparison with /sup 81m/Kr and /sup 127/Xe

Journal Article:

Abstract

The production of monodisperse human albumin millimicrospheres (diameter 1 ..mu..m) and labeling with /sup 99m/Tc is described. A system constructed to nebulize and deliver a dry aerosol yielded a lung delivery efficiency of approximately 25%. In 48 patients without and with varying degrees of chronic obstructive lung disease, quantitative comparison with /sup 81m/Kr (penetration index, regional distribution of activity in the lungs) demonstrated similar penetration of the particles to the lung periphery (r = 0.89 and r = 0.94, respectively). Qualitative comparison with /sup 81m/Kr or /sup 127/Xe showed complete or a high degree of diagnostic agreement in all but one patient. Semiquantitative scoring of hot spots as a substrate of local turbulent airflow showed a close inverse correlation (r = -0.82) with the forced expiratory volume in 1 s (FEV 1.0%), thus providing additional information about the severity of the airway obstruction. In 24 patients with suspected pulmonary embolism, complete agreement between aerosol and /sup 81m/Kr images was found in all patients studied. For same-day ventilation/perfusion studies, labeling of the millimicrospheres with /sup 111/In yielded images of comparable quality to those obtained with the /sup 99m/Tc-labeled aerosol.
Publication Date:
May 01, 1985
Product Type:
Journal Article
Reference Number:
FRG-84-05943; EDB-85-126053
Resource Relation:
Journal Name: Eur. J. Nucl. Med.; (Germany, Federal Republic of); Journal Volume: 10:9-10
Subject:
62 RADIOLOGY AND NUCLEAR MEDICINE; AEROSOL GENERATORS; DIAGNOSTIC USES; LUNGS; SCINTISCANNING; VENTILATION; AEROSOLS; ALBUMINS; COMPARATIVE EVALUATIONS; IMAGES; ISOMERIC NUCLEI; KRYPTON 81; LABELLING; MICROSPHERES; PATIENTS; RADIOPHARMACEUTICALS; RESPIRATORY SYSTEM DISEASES; TECHNETIUM 99; XENON 127; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COLLOIDS; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; DISPERSIONS; DRUGS; ELECTRON CAPTURE RADIOISOTOPES; EVEN-ODD NUCLEI; HOURS LIVING RADIOISOTOPES; INTERMEDIATE MASS NUCLEI; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; KRYPTON ISOTOPES; LABELLED COMPOUNDS; NUCLEI; ODD-EVEN NUCLEI; ORGANIC COMPOUNDS; ORGANS; PROTEINS; RADIOISOTOPE SCANNING; RADIOISOTOPES; RESPIRATORY SYSTEM; SECONDS LIVING RADIOISOTOPES; SOLS; TECHNETIUM ISOTOPES; USES; XENON ISOTOPES; YEARS LIVING RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics
OSTI ID:
5410504
Country of Origin:
Germany
Language:
English
Other Identifying Numbers:
Journal ID: CODEN: EJNMD
Submitting Site:
HEDB
Size:
Pages: 411-416
Announcement Date:

Journal Article:

Citation Formats

Koehn, H, Mostbeck, A, Klech, H, Kummer, F, Angelberger, P, Strigl, A, and Zolle, I. Dry aerosol of monodisperse millimicrospheres for ventilation imaging: Production, delivery system, and clinical results in comparison with /sup 81m/Kr and /sup 127/Xe. Germany: N. p., 1985. Web.
Koehn, H, Mostbeck, A, Klech, H, Kummer, F, Angelberger, P, Strigl, A, & Zolle, I. Dry aerosol of monodisperse millimicrospheres for ventilation imaging: Production, delivery system, and clinical results in comparison with /sup 81m/Kr and /sup 127/Xe. Germany.
Koehn, H, Mostbeck, A, Klech, H, Kummer, F, Angelberger, P, Strigl, A, and Zolle, I. 1985. "Dry aerosol of monodisperse millimicrospheres for ventilation imaging: Production, delivery system, and clinical results in comparison with /sup 81m/Kr and /sup 127/Xe." Germany.
@misc{etde_5410504,
title = {Dry aerosol of monodisperse millimicrospheres for ventilation imaging: Production, delivery system, and clinical results in comparison with /sup 81m/Kr and /sup 127/Xe}
author = {Koehn, H, Mostbeck, A, Klech, H, Kummer, F, Angelberger, P, Strigl, A, and Zolle, I}
abstractNote = {The production of monodisperse human albumin millimicrospheres (diameter 1 ..mu..m) and labeling with /sup 99m/Tc is described. A system constructed to nebulize and deliver a dry aerosol yielded a lung delivery efficiency of approximately 25%. In 48 patients without and with varying degrees of chronic obstructive lung disease, quantitative comparison with /sup 81m/Kr (penetration index, regional distribution of activity in the lungs) demonstrated similar penetration of the particles to the lung periphery (r = 0.89 and r = 0.94, respectively). Qualitative comparison with /sup 81m/Kr or /sup 127/Xe showed complete or a high degree of diagnostic agreement in all but one patient. Semiquantitative scoring of hot spots as a substrate of local turbulent airflow showed a close inverse correlation (r = -0.82) with the forced expiratory volume in 1 s (FEV 1.0%), thus providing additional information about the severity of the airway obstruction. In 24 patients with suspected pulmonary embolism, complete agreement between aerosol and /sup 81m/Kr images was found in all patients studied. For same-day ventilation/perfusion studies, labeling of the millimicrospheres with /sup 111/In yielded images of comparable quality to those obtained with the /sup 99m/Tc-labeled aerosol.}
journal = {Eur. J. Nucl. Med.; (Germany, Federal Republic of)}
volume = {10:9-10}
journal type = {AC}
place = {Germany}
year = {1985}
month = {May}
}